PDB entry 6o3b

View 6o3b on RCSB PDB site
Description: Crystal structure of Frizzled 7 CRD in complex with F6 Fab
Class: signaling protein
Keywords: Receptor, Wnt, Frizzled, CRD, Antibody, SIGNALING PROTEIN
Deposited on 2019-02-26, released 2019-04-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-04-03, with a file datestamp of 2019-03-29.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Antibody Fab F6, Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3B (0-End)
    Domains in SCOPe 2.07: d6o3ba1, d6o3ba2
  • Chain 'B':
    Compound: Antibody Fab F6, Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3B (0-End)
  • Chain 'C':
    Compound: Frizzled-7
    Species: Homo sapiens [TaxId:9606]
    Gene: FZD7
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75084 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d6o3bc1, d6o3bc2
  • Chain 'E':
    Compound: Antibody Fab F6, Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3B (0-End)
    Domains in SCOPe 2.07: d6o3be1, d6o3be2
  • Chain 'G':
    Compound: Antibody Fab F6, Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3B (0-220)
  • Chain 'H':
    Compound: Frizzled-7
    Species: Homo sapiens [TaxId:9606]
    Gene: FZD7
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75084 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d6o3bh1, d6o3bh2
  • Heterogens: GOL, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6o3bA (A:)
diqmtqspsslsasvgdrvtitcrasqsvssavawyqqkpgkapklliysasslysgvps
rfsgsrsgtdftltisslqpedfatyycqqwaygpftfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6o3bA (A:)
diqmtqspsslsasvgdrvtitcrasqsvssavawyqqkpgkapklliysasslysgvps
rfsgsrsgtdftltisslqpedfatyycqqwaygpftfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6o3bC (C:)
tgsvpdhgfcqpisiplctdiaynqtilpnllghtnqedaglevhqfyplvkvqcspelr
fflcsmyapvctvldqaippcrslcerarqgcealmnkfgfqwperlrcenfpvhgagei
cvgqntsdgsggpgggptay

    Sequence, based on observed residues (ATOM records): (download) 
    >6o3bC (C:)
tgsvpdhgfcqpisiplctdiaynqtilpnllghtnqedaglevhqfyplvkvqcspelr
fflcsmyapvctvldqaippcrslcerarqgcealmnkfgfqwperlrcenfpvhgagei
cvgqnt

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6o3bE (E:)
diqmtqspsslsasvgdrvtitcrasqsvssavawyqqkpgkapklliysasslysgvps
rfsgsrsgtdftltisslqpedfatyycqqwaygpftfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6o3bE (E:)
diqmtqspsslsasvgdrvtitcrasqsvssavawyqqkpgkapklliysasslysgvps
rfsgsrsgtdftltisslqpedfatyycqqwaygpftfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6o3bH (H:)
tgsvpdhgfcqpisiplctdiaynqtilpnllghtnqedaglevhqfyplvkvqcspelr
fflcsmyapvctvldqaippcrslcerarqgcealmnkfgfqwperlrcenfpvhgagei
cvgqntsdgsggpgggptay

    Sequence, based on observed residues (ATOM records): (download) 
    >6o3bH (H:)
tgsvpdhgfcqpisiplctdiaynqtilpnllghtnqedaglevhqfyplvkvqcspelr
fflcsmyapvctvldqaippcrslcerarqgcealmnkfgfqwperlrcenfpvhgagei
cvgq