PDB entry 6o3a

View 6o3a on RCSB PDB site
Description: Crystal structure of Frizzled 7 CRD in complex with F7.B Fab
Class: signaling protein
Keywords: Receptor, Wnt, Frizzled, CRD, Antibody, SIGNALING PROTEIN
Deposited on 2019-02-26, released 2019-04-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Antibody F7.B Fab, Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3A (0-211)
    Domains in SCOPe 2.08: d6o3aa1, d6o3aa2
  • Chain 'B':
    Compound: Antibody F7.B Fab, Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3A (0-217)
    Domains in SCOPe 2.08: d6o3ab_
  • Chain 'E':
    Compound: Frizzled-7
    Species: Homo sapiens [TaxId:9606]
    Gene: FZD7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o3ae_
  • Heterogens: CXS, EDO, NA, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6o3aA (A:)
diqmtqspsslsasvgdrvtitcrasqsvssavawyqqkpgkapklliysasslysgvps
rfsgsrsgtdftltisslqpedfatyycqqyyslftfgqgtkveikrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
skadyekhkvyacevthqglsspvtksfnrge

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6o3aB (B:)
evqlvesggglvqpggslrlscaasgfnfssssihwvrqapgkglewvayiypsydytyy
adsvkgrftisadtskntaylqmnslraedtavyycargyfytwggmdywgqgtlvtvss
astkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtktytcnvdhkpsntkvdkrv

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6o3aE (E:)
svpdhgfcqpisiplctdiaynqtilpnllghtnqedaglevhqfyplvkvqcspelrff
lcsmyapvctvldqaippcrslcerarqgcealmnkfgfqwperlrcenfpvhgageicv
gqntsdgsggpgggptay

    Sequence, based on observed residues (ATOM records): (download) 
    >6o3aE (E:)
fcqpisiplctdiaynqtilpnllghtnqedaglevhqfyplvkvqcspelrfflcsmya
pvctvldqaippcrslcerarqgcealmnkfgfqwperlrcenfpvhgageicvgqnt