PDB entry 6o0m

View 6o0m on RCSB PDB site
Description: crystal structure of BCL-2 F104L mutation with venetoclax
Class: apoptosis
Keywords: BCL-2, Venetoclax, complex, Protein-protein interface inhibitor, resistance mutation, FDA approved drug complex, APOPTOSIS
Deposited on 2019-02-16, released 2019-05-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415 (Start-33)
    • Uniprot Q07817 (Start-49)
    • Uniprot P10415 (50-End)
      • engineered mutation (62)
    Domains in SCOPe 2.08: d6o0ma_
  • Heterogens: LBM, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6o0mA (A:)
mahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhltlrqag
ddlsrryrrdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmcves
vnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr

    Sequence, based on observed residues (ATOM records): (download) 
    >6o0mA (A:)
gydnreivmkyihyklsqrgyewdagdsevvhltlrqagddlsrryrrdfaemssqlhlt
pftargrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteyln
rhlhtwiqdnggwdafvelyg