PDB entry 6o0l

View 6o0l on RCSB PDB site
Description: crystal structure of BCL-2 G101V mutation with venetoclax
Class: apoptosis
Keywords: BCL-2, Venetoclax, complex, Protein-protein interface inhibitor, resistance mutation, FDA approved drug complex, APOPTOSIS
Deposited on 2019-02-16, released 2019-05-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415
    • Uniprot Q07817 (Start-49)
    • Uniprot P10415 (50-End)
      • engineered mutation (59)
    Domains in SCOPe 2.08: d6o0la_
  • Chain 'C':
    Compound: Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415
    • Uniprot Q07817 (Start-49)
    • Uniprot P10415 (50-End)
      • engineered mutation (59)
    Domains in SCOPe 2.08: d6o0lc_
  • Heterogens: LBM, PEG, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6o0lA (A:)
mahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhltlrqav
ddfsrryrrdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmcves
vnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr

    Sequence, based on observed residues (ATOM records): (download) 
    >6o0lA (A:)
ydnreivmkyihyklsqrgyewdagsevvhltlrqavddfsrryrrdfaemssqlhltpf
targrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrh
lhtwiqdnggwdafvelyg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6o0lC (C:)
mahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhltlrqav
ddfsrryrrdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmcves
vnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr

    Sequence, based on observed residues (ATOM records): (download) 
    >6o0lC (C:)
gydnreivmkyihyklsqrgyewdagsevvhltlrqavddfsrryrrdfaemssqlhltp
ftargrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnr
hlhtwiqdnggwdafvelyg