PDB entry 6o03

View 6o03 on RCSB PDB site
Description: monobody (mc17) bound to tyrosine kinase binding domain of e3 ubiquitin ligase cbl
Deposited on 2019-02-15, released 2020-08-19
The last revision was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase CBL
    Species: Homo sapiens [TaxId:9606]
    Gene: CBL, CBL2, RNF55
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22681
      • engineered mutation (261)
  • Chain 'B':
    Compound: E3 ubiquitin-protein ligase CBL
    Species: Homo sapiens [TaxId:9606]
    Gene: CBL, CBL2, RNF55
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22681
      • engineered mutation (261)
  • Chain 'C':
    Compound: Monobody (MC17)
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O03 (Start-91)
  • Chain 'D':
    Compound: Monobody (MC17)
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O03 (Start-91)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6o03A (A:)
gsppgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsryeg
kmetlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmlae
lkgifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleamal
kstidltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqkf
ihkpgsyifrlsctrlgqwaieyvtadgnilqtiphnkplfqalidgfregfylfpdgrn
qnpdltglc

    Sequence, based on observed residues (ATOM records):
    >6o03A (A:)
dkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsryegkmetlge
neyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmlaelkgifps
glfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleamalkstidlt
cndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqkfihkpgsy
ifrlsctrlgqwaieyvtadgnilqtiphnkplfqalidgfregfylfpdgrnqnpdl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6o03B (B:)
gsppgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsryeg
kmetlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmlae
lkgifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleamal
kstidltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqkf
ihkpgsyifrlsctrlgqwaieyvtadgnilqtiphnkplfqalidgfregfylfpdgrn
qnpdltglc

    Sequence, based on observed residues (ATOM records):
    >6o03B (B:)
pgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsryegkme
tlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmlaelkg
ifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleamalkst
idltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqkfihk
pgsyifrlsctrlgqwaieyvtadgnilqtiphnkplfqalidgfregfylfpdgrnqnp
dl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6o03C (C:)
gsvssvptklevvaatptslliswdapavtvfyyyitygetggnspvqeftvpgskstat
isglkpgvdytitvyamyygkvyspisinyrt

    Sequence, based on observed residues (ATOM records):
    >6o03C (C:)
vptklevvaatptslliswdapavtvfyyyitygetggnspvqeftvpgskstatisglk
pgvdytitvyamyygkvyspisinyrt

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6o03D (D:)
gsvssvptklevvaatptslliswdapavtvfyyyitygetggnspvqeftvpgskstat
isglkpgvdytitvyamyygkvyspisinyrt

    Sequence, based on observed residues (ATOM records):
    >6o03D (D:)
vptklevvaatptslliswdapavtvfyyyitygetggnspvqeftvpgskstatisglk
pgvdytitvyamyygkvyspisinyrt