PDB entry 6nzv

View 6nzv on RCSB PDB site
Description: Crystal structure of HCV NS3/4A protease in complex with compound 12
Class: viral protein/inhibitor
Keywords: viral protease inhibitor, voxilaprevir, hepatitis C virus, VIRAL PROTEIN, viral protein-inhibitor complex
Deposited on 2019-02-14, released 2019-07-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-08-21, with a file datestamp of 2019-08-16.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HCV NS3/4A protease
    Species: Hepatitis C virus subtype 1a [TaxId:31646]
    Database cross-references and differences (RAF-indexed):
    • Uniprot S4UY05 (24-End)
      • expression tag (9-23)
      • variant (33-34)
      • variant (37-38)
      • variant (41)
      • variant (67)
      • variant (72)
      • variant (92)
      • variant (106)
      • variant (179)
      • engineered mutation (188)
    Domains in SCOPe 2.08: d6nzva1, d6nzva2
  • Heterogens: L9J, ZN, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6nzvA (A:)
gshmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivsta
tqtflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctc
gssdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifraavs
trgvakavqfipveslettmrsp

    Sequence, based on observed residues (ATOM records): (download) 
    >6nzvA (A:)
kgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivstatqtflatsi
ngvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctcgssdlylvt
rhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifraavstrgvakavq
fipveslettm