PDB entry 6nzu

View 6nzu on RCSB PDB site
Description: structure of the human frataxin-bound iron-sulfur cluster assembly complex
Deposited on 2019-02-14, released 2019-05-22
The last revision was dated 2019-07-10, with a file datestamp of 2019-07-05.
Experiment type: EM
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cysteine desulfurase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: NFS1, NIFS, HUSSY-08
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: LYR motif-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: LYRM4, C6orf149, ISD11, CGI-203
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HD34
      • conflict (11)
  • Chain 'C':
    Compound: Acyl carrier protein
    Species: Escherichia coli [TaxId:562]
    Gene: acpP, DQL48_09575, EOL36_14065
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ISCU, NIFUN
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Cysteine desulfurase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: NFS1, NIFS, HUSSY-08
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: LYR motif-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: LYRM4, C6orf149, ISD11, CGI-203
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HD34
      • conflict (11)
  • Chain 'G':
    Compound: Acyl carrier protein
    Species: Escherichia coli [TaxId:562]
    Gene: acpP, DQL48_09575, EOL36_14065
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ISCU, NIFUN
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Frataxin, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: FXN, FRDA, X25
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Frataxin, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: FXN, FRDA, X25
    Database cross-references and differences (RAF-indexed):
  • Heterogens: PLP, 8Q1, ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6nzuA (A:)
mlrplymdvqattpldprvldamlpylinyygnphsrthaygweseaamerarqqvasli
gadpreiiftsgatesnniaikgvarfyrsrkkhlittqtehkcvldscrsleaegfqvt
ylpvqksgiidlkeleaaiqpdtslvsvmtvnneigvkqpiaeigricssrkvyfhtdaa
qavgkipldvndmkidlmsisghkiygpkgvgaiyirrrprvrvealqsgggqergmrsg
tvptplvvglgaacevaqqemeydhkrisklserliqnimkslpdvvmngdpkhhypgci
nlsfayvegesllmalkdvalssgsactsaslepsyvlraigtdedlahssirfgigrft
teeevdytvekciqhvkrlremsplwemvqdgidlksikwtqh

    Sequence, based on observed residues (ATOM records):
    >6nzuA (A:)
lrplymdvqattpldprvldamlpylinyygnphsrthaygweseaamerarqqvaslig
adpreiiftsgatesnniaikgvarfyrsrkkhlittqtehkcvldscrsleaegfqvty
lpvqksgiidlkeleaaiqpdtslvsvmtvnneigvkqpiaeigricssrkvyfhtdaaq
avgkipldvndmkidlmsisghkiygpkgvgaiyirrrprvrvealqsgggqergmrsgt
vptplvvglgaacevaqqemeydhkrisklserliqnimkslpdvvmngdpkhhypgcin
lsfayvegesllmalkdvalssgsactsaslepsyvlraigtdedlahssirfgigrftt
eeevdytvekciqhvkrlremsplwemvqdgidlksikwtqh

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6nzuB (B:)
smaassraqvlalyramlreskrfsaynyrtyavrrirdafrenknvkdpveiqtlvnka
krdlgvirrqvhigqlystdkliienrdmprt

    Sequence, based on observed residues (ATOM records):
    >6nzuB (B:)
sraqvlalyramlreskrfsaynyrtyavrrirdafrenknvkdpveiqtlvnkakrdlg
virrqvhigqlystdkliien

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6nzuC (C:)
mstieervkkiigeqlgvkqeevtnnasfvedlgadsldtvelvmaleeefdteipdeea
ekittvqaaidyin

    Sequence, based on observed residues (ATOM records):
    >6nzuC (C:)
eervkkiigeqlgvkqeevtnnasfvedlgadsldtvelvmaleeefdteipdeeaekit
tvqaaidyin

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6nzuD (D:)
myhkkvvdhyenprnvgsldktsknvgtglvgapacgdvmklqiqvdekgkivdarfktf
gcgsaiassslatewvkgktveealtikntdiakelclppvklhcsmlaedaikaalady
klkq

    Sequence, based on observed residues (ATOM records):
    >6nzuD (D:)
yhkkvvdhyenprnvgsldktsknvgtglvgapacgdvmklqiqvdekgkivdarfktfg
cgsaiassslatewvkgktveealtikntdiakelclppvklhcsmlaedaikaaladyk
lkq

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6nzuE (E:)
mlrplymdvqattpldprvldamlpylinyygnphsrthaygweseaamerarqqvasli
gadpreiiftsgatesnniaikgvarfyrsrkkhlittqtehkcvldscrsleaegfqvt
ylpvqksgiidlkeleaaiqpdtslvsvmtvnneigvkqpiaeigricssrkvyfhtdaa
qavgkipldvndmkidlmsisghkiygpkgvgaiyirrrprvrvealqsgggqergmrsg
tvptplvvglgaacevaqqemeydhkrisklserliqnimkslpdvvmngdpkhhypgci
nlsfayvegesllmalkdvalssgsactsaslepsyvlraigtdedlahssirfgigrft
teeevdytvekciqhvkrlremsplwemvqdgidlksikwtqh

    Sequence, based on observed residues (ATOM records):
    >6nzuE (E:)
lrplymdvqattpldprvldamlpylinyygnphsrthaygweseaamerarqqvaslig
adpreiiftsgatesnniaikgvarfyrsrkkhlittqtehkcvldscrsleaegfqvty
lpvqksgiidlkeleaaiqpdtslvsvmtvnneigvkqpiaeigricssrkvyfhtdaaq
avgkipldvndmkidlmsisghkiygpkgvgaiyirrrprvrvealqsgggqergmrsgt
vptplvvglgaacevaqqemeydhkrisklserliqnimkslpdvvmngdpkhhypgcin
lsfayvegesllmalkdvalssgsactsaslepsyvlraigtdedlahssirfgigrftt
eeevdytvekciqhvkrlremsplwemvqdgidlksikwtqh

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6nzuF (F:)
smaassraqvlalyramlreskrfsaynyrtyavrrirdafrenknvkdpveiqtlvnka
krdlgvirrqvhigqlystdkliienrdmprt

    Sequence, based on observed residues (ATOM records):
    >6nzuF (F:)
sraqvlalyramlreskrfsaynyrtyavrrirdafrenknvkdpveiqtlvnkakrdlg
virrqvhigqlystdkliien

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6nzuG (G:)
mstieervkkiigeqlgvkqeevtnnasfvedlgadsldtvelvmaleeefdteipdeea
ekittvqaaidyin

    Sequence, based on observed residues (ATOM records):
    >6nzuG (G:)
eervkkiigeqlgvkqeevtnnasfvedlgadsldtvelvmaleeefdteipdeeaekit
tvqaaidyin

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6nzuH (H:)
myhkkvvdhyenprnvgsldktsknvgtglvgapacgdvmklqiqvdekgkivdarfktf
gcgsaiassslatewvkgktveealtikntdiakelclppvklhcsmlaedaikaalady
klkq

    Sequence, based on observed residues (ATOM records):
    >6nzuH (H:)
yhkkvvdhyenprnvgsldktsknvgtglvgapacgdvmklqiqvdekgkivdarfktfg
cgsaiassslatewvkgktveealtikntdiakelclppvklhcsmlaedaikaaladyk
lkq

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6nzuI (I:)
smsgtlghpgsldettyerlaeetldslaeffedladkpytfedydvsfgsgvltvklgg
dlgtyvinkqtpnkqiwlsspssgpkrydwtgknwvyshdgvslhellaaeltkalktkl
dlsslaysgkda

    Sequence, based on observed residues (ATOM records):
    >6nzuI (I:)
ldettyerlaeetldslaeffedladkpytfedydvsfgsgvltvklggdlgtyvinkqt
pnkqiwlsspssgpkrydwtgknwvyshdgvslhellaaeltkalktkldlsslaysg

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6nzuJ (J:)
smsgtlghpgsldettyerlaeetldslaeffedladkpytfedydvsfgsgvltvklgg
dlgtyvinkqtpnkqiwlsspssgpkrydwtgknwvyshdgvslhellaaeltkalktkl
dlsslaysgkda

    Sequence, based on observed residues (ATOM records):
    >6nzuJ (J:)
ldettyerlaeetldslaeffedladkpytfedydvsfgsgvltvklggdlgtyvinkqt
pnkqiwlsspssgpkrydwtgknwvyshdgvslhellaaeltkalktkldlsslaysg