PDB entry 6nzh

View 6nzh on RCSB PDB site
Description: CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_40 AKA 6-cyclopropaneamido-4-[(2-methanesulfonylphenyl)amino]-N-methylpyridine-3-carboxamide
Class: transferase
Keywords: jtk1, transferase
Deposited on 2019-02-13, released 2019-07-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-06, with a file datestamp of 2019-11-01.
Experiment type: XRAY
Resolution: 2.73 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Non-receptor tyrosine-protein kinase TYK2
    Species: Homo sapiens [TaxId:9606]
    Gene: TYK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6nzha_
  • Chain 'B':
    Compound: Non-receptor tyrosine-protein kinase TYK2
    Species: Homo sapiens [TaxId:9606]
    Gene: TYK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6nzhb_
  • Heterogens: L9A, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6nzhA (A:)
mgsshhhhhhssgetvrfqghmnlsqlsfhrvdqkeitqlshlgqgtrtnvyegrlrveg
sgdpeegkmddedplvpgrdrgqelrvvlkvldpshhdialafyetaslmsqvshthlaf
vhgvcvrgpenimvteyvehgpldvwlrrerghvpmawkmvvaqqlasalsylenknlvh
gnvcgrnillarlglaegtspfiklsdpgvglgalsreerveripwlapeclpggansls
tamdkwgfgatlleicfdgeaplqsrspsekehfyqrqhrlpepscpqlatltsqcltye
ptqrpsfrtilrdltrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nzhA (A:)
fhrvdqkeitqlshlgqgtrtnvyegrllrvvlkvldpshhdialafyetaslmsqvsht
hlafvhgvcvrgpenimvteyvehgpldvwlrrerghvpmawkmvvaqqlasalsylenk
nlvhgnvcgrnillarlglaegtspfiklsdpgvglgalsreerveripwlapeclpsta
mdkwgfgatlleicfdgeaplspsekehfyqrqhrlpepscpqlatltsqcltyeptqrp
sfrtilrdl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6nzhB (B:)
mgsshhhhhhssgetvrfqghmnlsqlsfhrvdqkeitqlshlgqgtrtnvyegrlrveg
sgdpeegkmddedplvpgrdrgqelrvvlkvldpshhdialafyetaslmsqvshthlaf
vhgvcvrgpenimvteyvehgpldvwlrrerghvpmawkmvvaqqlasalsylenknlvh
gnvcgrnillarlglaegtspfiklsdpgvglgalsreerveripwlapeclpggansls
tamdkwgfgatlleicfdgeaplqsrspsekehfyqrqhrlpepscpqlatltsqcltye
ptqrpsfrtilrdltrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nzhB (B:)
sfhrvdqkeitqlshlgqgtrtnvyegrlrelrvvlkvldpshhdialafyetaslmsqv
shthlafvhgvcvrgpenimvteyvehgpldvwlrrerghvpmawkmvvaqqlasalsyl
enknlvhgnvcgrnillarlglspfiklsdpgvglgalsreerveripwlapeclstamd
kwgfgatlleicfdgeaplrspsekehfyqrqhrlpepscpqlatltsqcltyeptqrps
frtilrdlt