PDB entry 6nyh

View 6nyh on RCSB PDB site
Description: Structure of human RIPK1 kinase domain in complex with GNE684
Class: immune system
Keywords: RIP1, kinase, RIP, RIP1K RIPK1, IMMUNE SYSTEM, Transferase-Transferase inhibitor complex
Deposited on 2019-02-11, released 2019-05-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-295)
      • engineered mutation (35)
      • engineered mutation (128)
      • engineered mutation (234)
      • engineered mutation (241)
    Domains in SCOPe 2.08: d6nyha_
  • Chain 'B':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-295)
      • engineered mutation (35)
      • engineered mutation (128)
      • engineered mutation (234)
      • engineered mutation (241)
    Domains in SCOPe 2.08: d6nyhb_
  • Heterogens: L8D, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6nyhA (A:)
gsmqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgpnciehne
alleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstplsvkgri
ileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnneehnelre
vdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyenaiaeqqli
maiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfylsqle

    Sequence, based on observed residues (ATOM records): (download) 
    >6nyhA (A:)
nvikmkssdflekvslafhrtqglmimktvykgpnciehnealleeakmmnrlrhsrvvk
llgviieegkyslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgkgvihk
dlkpenilvdndfhikiadlglasfkmwsklnneehnegtlyymapehlndvnakpteks
dvysfavvlwaifankepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklcwe
anpearptfpgieekfrpfylsqle

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6nyhB (B:)
gsmqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgpnciehne
alleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstplsvkgri
ileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnneehnelre
vdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyenaiaeqqli
maiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfylsqle

    Sequence, based on observed residues (ATOM records): (download) 
    >6nyhB (B:)
kmkssdfleskvslafhqglmimktvehnealleeakmmnrlrhsrvvkllgviieegky
slvmeymekgnlmhvlkastplsvkgriileiiegmaylhgkgvihkdlkpenilvdndf
hikiadlglasfkmwsklngtlyymapehlndvnakpteksdvysfavvlwaifankepy
enaiaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpf
ylsqle