PDB entry 6nyb

View 6nyb on RCSB PDB site
Description: structure of a mapk pathway complex
Deposited on 2019-02-11, released 2019-10-09
The last revision was dated 2020-04-22, with a file datestamp of 2020-04-17.
Experiment type: EM
Resolution: 4.1 Å
R-factor: N/A
AEROSPACI score: 0.05 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02750
      • engineered mutation (239)
      • engineered mutation (243)
  • Chain 'C':
    Compound: 14-3-3 protein zeta
    Species: Spodoptera exigua [TaxId:7107]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: 14-3-3 protein zeta
    Species: Spodoptera exigua [TaxId:7107]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: AGS, ZN, ADP, MG, LCJ

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6nybA (A:)
    msyyhhhhhhhhdipttenlyfqgamdmaalsggggggaepgqalfngdmepeagagaga
    aassaadpaipeevwnikqmikltqehiealldkfggehnppsiyleayeeytskldalq
    qreqqlleslgngtdfsvsssasmdtvtsssssslsvlpsslsvfqnptdvarsnpkspq
    kpivrvflpnkqrtvvparcgvtvrdslkkalmmrglipeccavyriqdgekkpigwdtd
    iswltgeelhvevlenvpltthnfvrktfftlafcdfcrkllfqgfrcqtcgykfhqrcs
    tevplmcvnydqldllfvskffehhpipqeeaslaetaltsgsspsapasdsigpqilts
    pspsksipipqpfrpadedhrnqfgqrdrsssapnvhintiepvniddlirdqgfrgdgg
    sttglsatppaslpgsltnvkalqkspgpqrerksssssedrnrmktlgrrdssddweip
    dgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrhvni
    llfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylhaksii
    hrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevirmqdknpy
    sfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlm
    aeclkkkrderplfpqilasiellarslpkihrsasepslnragfqtedfslyacaspkt
    piqaggygafpvhgtsawshpqfek
    

    Sequence, based on observed residues (ATOM records):
    >6nybA (A:)
    tthnfvrktfftlafcdfcrkllfqgfrcqtcgykfhqrcstevplmcvrdrsssapnvh
    dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
    rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
    aksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevirmq
    dknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpka
    mkrlmaeclkkkrderplfpqilasiellarslpkihrsasepslnragf
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6nybB (B:)
    mgsshhhhhhsavdenlyfqggmpkkkptpiqlnpapdgsavngtssaetnlealqkkle
    eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
    ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
    gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlida
    manafvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcq
    vegdaaetpprprtpgrplssygmdsrppmaifelldyivnepppklpsgvfslefqdfv
    nkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnqpstpthaagv
    

    Sequence, based on observed residues (ATOM records):
    >6nybB (B:)
    qkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirel
    qvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavik
    gltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidamanafvgtrsymsperl
    qgthysvqsdiwsmglslvemavgrypipppdpmaifelldyivnepppklpsgvfslef
    qdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnq
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6nybC (C:)
    msvdkeelvqraklaeqaeryddmaaamkevtetgvelsneernllsvayknvvgarrss
    wrvissieqktegserkqqmakeyrvkvekelreicydvlglldkhlipkasnpeskvfy
    lkmkgdyyrylaevatgetrnsvvedsqkayqdafeiskakmqpthpirlglalnfsvfy
    yeilnspdkacqlakqafddaiaeldtlnedsykdstlimqllrdnltlwtsdtqgdgde
    paeggdn
    

    Sequence, based on observed residues (ATOM records):
    >6nybC (C:)
    dkeelvqraklaeqaeryddmaaamkevtetgvelsneernllsvayknvvgarrsswrv
    issieqktegserkqqmakeyrvkvekelreicydvlglldkhlipkasnpeskvfylkm
    kgdyyrylaevatgetrnsvvedsqkayqdafeiskakmqpthpirlglalnfsvfyyei
    lnspdkacqlakqafddaiaeldtlnedsykdstlimqllrdnltlwts
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6nybD (D:)
    msvdkeelvqraklaeqaeryddmaaamkevtetgvelsneernllsvayknvvgarrss
    wrvissieqktegserkqqmakeyrvkvekelreicydvlglldkhlipkasnpeskvfy
    lkmkgdyyrylaevatgetrnsvvedsqkayqdafeiskakmqpthpirlglalnfsvfy
    yeilnspdkacqlakqafddaiaeldtlnedsykdstlimqllrdnltlwtsdtqgdgde
    paeggdn
    

    Sequence, based on observed residues (ATOM records):
    >6nybD (D:)
    dkeelvqraklaeqaeryddmaaamkevtetgvelsneernllsvayknvvgarrsswrv
    issieqktegserkqqmakeyrvkvekelreicydvlglldkhlipkasnpeskvfylkm
    kgdyyrylaevatgetrnsvvedsqkayqdafeiskakmqpthpirlglalnfsvfyyei
    lnspdkacqlakqafddaiaeldtlnedsykdstlimqllrdnltlwts