PDB entry 6nu5

View 6nu5 on RCSB PDB site
Description: pyruvate kinase m2 mutant - s437y in complex with l-cysteine
Deposited on 2019-01-30, released 2019-08-21
The last revision was dated 2019-11-27, with a file datestamp of 2019-11-22.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14618 (Start-550)
      • engineered mutation (456)
  • Chain 'B':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14618 (Start-550)
      • engineered mutation (456)
  • Heterogens: CYS, OXL, SCN, B3P, MG, K, EDO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6nu5A (A:)
mgsshhhhhhssglvprgshmskphseagtafiqtqqlhaamadtflehmcrldidsppi
tarntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfas
dpilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwld
yknickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpa
vsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrf
deileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprp
traegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrr
lapitsdpteatavgaveasfkccsgaiivltksgryahqvaryrprapiiavtrnpqta
rqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsg
ftntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6nu5A (A:)
eagtafiqtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemik
sgmnvarlnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikg
sgtaevelkkgatlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvk
qkgadflvtevenggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfir
kasdvhevrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekv
flaqkmmigrcnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgeta
kgdypleavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsg
aiivltksgryahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedv
dlrvnfamnvgkargffkkgdvvivltgwrpftntmrvvpvp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6nu5B (B:)
mgsshhhhhhssglvprgshmskphseagtafiqtqqlhaamadtflehmcrldidsppi
tarntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfas
dpilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwld
yknickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpa
vsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrf
deileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprp
traegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrr
lapitsdpteatavgaveasfkccsgaiivltksgryahqvaryrprapiiavtrnpqta
rqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsg
ftntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6nu5B (B:)
qtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvar
lnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikgsgtaeve
lkkgatlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkgadfl
vtevenggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhe
vrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmm
igrcnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdyple
avrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltk
sgryahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfa
mnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp