PDB entry 6nu1

View 6nu1 on RCSB PDB site
Description: crystal structure of human pkm2 in complex with l-cysteine
Deposited on 2019-01-30, released 2019-08-21
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CYS, FBP, MG, OXL, K, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6nu1A (A:)
mgsshhhhhhssglvprgshmskphseagtafiqtqqlhaamadtflehmcrldidsppi
tarntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfas
dpilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwld
yknickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpa
vsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrf
deileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprp
traegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrr
lapitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqta
rqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsg
ftntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6nu1A (A:)
qtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvar
lnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtevelkkkitlcd
enilwldykniskiyvddglislenggslgkkgvnlpgaavdlpavsekdiqdlkfgveq
dvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfdeileasdgimvarg
dlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprptraegsdvanavldg
adcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavg
aveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlck
dpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6nu1B (B:)
mgsshhhhhhssglvprgshmskphseagtafiqtqqlhaamadtflehmcrldidsppi
tarntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfas
dpilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwld
yknickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpa
vsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrf
deileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprp
traegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrr
lapitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqta
rqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsg
ftntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6nu1B (B:)
qtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvar
lnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtyknigskiyvdd
glisengggvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlg
ekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmigrcnr
agkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleavrmqh
liareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksgrsah
qvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgka
rgffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6nu1C (C:)
mgsshhhhhhssglvprgshmskphseagtafiqtqqlhaamadtflehmcrldidsppi
tarntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfas
dpilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwld
yknickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpa
vsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrf
deileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprp
traegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrr
lapitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqta
rqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsg
ftntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6nu1C (C:)
tqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvarl
nfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikgsgtaevel
kkgatlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkgaflvt
evenggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevr
kvlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmig
rcnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleav
rmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksg
rsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamn
vgkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6nu1D (D:)
mgsshhhhhhssglvprgshmskphseagtafiqtqqlhaamadtflehmcrldidsppi
tarntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfas
dpilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwld
yknickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpa
vsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrf
deileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprp
traegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrr
lapitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqta
rqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsg
ftntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6nu1D (D:)
qtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvar
lnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikgsgtaeve
lkkgatlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkflvte
venggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevrk
vlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmigr
cnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleavr
mqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksgr
sahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamnv
gkargffkkgdvvivltgwrpgsgftntmrvvpvp