PDB entry 6ntm

View 6ntm on RCSB PDB site
Description: Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-232 in Complex with the Reactivator, HI-6
Class: hydrolase/hydrolase inhibitor
Keywords: hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex
Deposited on 2019-01-29, released 2020-07-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-24.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ntma_
  • Chain 'B':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ntmb_
  • Heterogens: L0S, HI6, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ntmA (A:)
gredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvd
attfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygg
gfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalq
wvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgm
gearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvp
vvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraefla
gvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaq
garvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywa
nfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpklls
at

    Sequence, based on observed residues (ATOM records): (download) 
    >6ntmA (A:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcppggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdgd
flsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrvg
vpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarvy
ayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfart
gdpnepapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ntmB (B:)
gredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvd
attfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygg
gfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalq
wvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgm
gearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvp
vvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraefla
gvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaq
garvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywa
nfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpklls
at

    Sequence, based on observed residues (ATOM records): (download) 
    >6ntmB (B:)
daellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdatt
fqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggfy
sgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwvq
envaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmgea
rrratqlahlvgcppndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdgdfls
dtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrvgvpq
vsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarvyayv
fehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfartgdp
nepapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsa