PDB entry 6nt9

View 6nt9 on RCSB PDB site
Description: cryo-em structure of the complex between human tbk1 and chicken sting
Deposited on 2019-01-28, released 2019-03-06
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: EM
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase TBK1
    Species: Homo sapiens [TaxId:9606]
    Gene: TBK1, NAK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UHD2 (0-End)
      • engineered mutation (134)
  • Chain 'B':
    Compound: Serine/threonine-protein kinase TBK1
    Species: Homo sapiens [TaxId:9606]
    Gene: TBK1, NAK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UHD2 (0-End)
      • engineered mutation (134)
  • Chain 'C':
    Compound: Stimulator of interferon genes protein
    Species: Gallus gallus [TaxId:9031]
    Gene: TMEM173
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Stimulator of interferon genes protein
    Species: Gallus gallus [TaxId:9031]
    Gene: TMEM173
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6nt9A (A:)
mqstsnhlwllsdilgqgatanvfrgrhkktgdlfaikvfnnisflrpvdvqmrefevlk
klnhknivklfaieeetttrhkvlimefcpcgslytvleepsnayglpeseflivlrdvv
ggmnhlrengivhrnikpgnimrvigedgqsvykltdfgaareleddeqfvslygteeyl
hpdmyeravlrkdhqkkygatvdlwsigvtfyhaatgslpfrpfegprrnkevmykiitg
kpsgaisgvqkaengpidwsgdmpvscslsrglqvlltpvlanileadqekcwgfdqffa
etsdilhrmvihvfslqqmtahkiyihsyntatifhelvykqtkiissnqeliyegrrlv
lepgrlaqhfpktteenpifvvsreplntigliyekislpkvhprydldgdasmakaitg
vvcyacriastlllyqelmrkgirwlielikddynetvhkktevvitldfcirniektvk
vyeklmkinleaaelgeisdihtkllrlsssqgtietslqdidsrlspggsladawahqe
gthpkdrnveklqvllncmteiyyqfkkdkaerrlayneeqihkfdkqklyyhatkamth
ftdecvkkyeaflnkseewirkmlhlrkqllsltnqcfdieeevskyqeytnelqetlpq
kmftassgikhtmtpiypssntlvemtlgmkklkeemegvvkelaennhilerfgsltmd
gglrnvdclgihrpdykddddk

    Sequence, based on observed residues (ATOM records):
    >6nt9A (A:)
mqstsnhlwllsdilgqgatanvfrgrhkktgdlfaikvfnnvdvqmrefevlkklnhkn
ivklfaieeetttrhkvlimefcpcgslytvleepsnayglpeseflivlrdvvggmnhl
rengivhrnikpgnimrvigedgqsvykltdfggteeylhpdatvdlwsigvtfyhaatg
slpfrpfekevmykiitgkpsgaisgvqkaengpidwsgdmpvscslsrglqvlltpvla
nileadqekcwgfdqffaetsdilhrmvihvfslqqmtahkiyihsyntatifhelvykq
tkiissnqeliyegrrlvlepgrlaqhfpktteenpifvvsreplntigliyekislpkv
hprydldgdasmakaitgvvcyacriastlllyqelmrkgirwlielikddynetvhkkt
evvitldfcirniektvkvyekgeisdihtkllrlsssqgtietslqdidsrlspggsla
dawahqegthpkdrnveklqvllncmteiyyqfkkdkaerrlayneeqihkfdkqklyyh
atkamthftdecvkkyeaflnkseewirkmlhlrkqllsltnqcfdieeevskyqeytne
lqetl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6nt9B (B:)
mqstsnhlwllsdilgqgatanvfrgrhkktgdlfaikvfnnisflrpvdvqmrefevlk
klnhknivklfaieeetttrhkvlimefcpcgslytvleepsnayglpeseflivlrdvv
ggmnhlrengivhrnikpgnimrvigedgqsvykltdfgaareleddeqfvslygteeyl
hpdmyeravlrkdhqkkygatvdlwsigvtfyhaatgslpfrpfegprrnkevmykiitg
kpsgaisgvqkaengpidwsgdmpvscslsrglqvlltpvlanileadqekcwgfdqffa
etsdilhrmvihvfslqqmtahkiyihsyntatifhelvykqtkiissnqeliyegrrlv
lepgrlaqhfpktteenpifvvsreplntigliyekislpkvhprydldgdasmakaitg
vvcyacriastlllyqelmrkgirwlielikddynetvhkktevvitldfcirniektvk
vyeklmkinleaaelgeisdihtkllrlsssqgtietslqdidsrlspggsladawahqe
gthpkdrnveklqvllncmteiyyqfkkdkaerrlayneeqihkfdkqklyyhatkamth
ftdecvkkyeaflnkseewirkmlhlrkqllsltnqcfdieeevskyqeytnelqetlpq
kmftassgikhtmtpiypssntlvemtlgmkklkeemegvvkelaennhilerfgsltmd
gglrnvdclgihrpdykddddk

    Sequence, based on observed residues (ATOM records):
    >6nt9B (B:)
mqstsnhlwllsdilgqgatanvfrgrhkktgdlfaikvfnnvdvqmrefevlkklnhkn
ivklfaieeetttrhkvlimefcpcgslytvleepsnayglpeseflivlrdvvggmnhl
rengivhrnikpgnimrvigedgqsvykltdfggteeylhpdatvdlwsigvtfyhaatg
slpfrpfekevmykiitgkpsgaisgvqkaengpidwsgdmpvscslsrglqvlltpvla
nileadqekcwgfdqffaetsdilhrmvihvfslqqmtahkiyihsyntatifhelvykq
tkiissnqeliyegrrlvlepgrlaqhfpktteenpifvvsreplntigliyekislpkv
hprydldgdasmakaitgvvcyacriastlllyqelmrkgirwlielikddynetvhkkt
evvitldfcirniektvkvyekgeisdihtkllrlsssqgtietslqdidsrlspggsla
dawahqegthpkdrnveklqvllncmteiyyqfkkdkaerrlayneeqihkfdkqklyyh
atkamthftdecvkkyeaflnkseewirkmlhlrkqllsltnqcfdieeevskyqeytne
lqetl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6nt9C (C:)
mpqdpstrssparllipepragrarhaacvllavcfvvlflsgeplapiirsvctqlaal
qlgvllkgccclaeeifhlhsrhhgslwqvlcscfpprwylalllvggsayldppedngh
sprlaltlsclcqllvlalglqklsavevseltesskknvahglawsyyigylkvvlprl
kecmeelsrtnpmlrahrdtwklhilvplgcdiwddlekadsniqyladlpetiltragi
krrvykhslyvirdkdnklrpcvlefasplqtlcamsqddcaafsreqrleqarlfyrsl
rdilgsskecaglyrliayeepaepeshflsglilwhlqqqqreeymvqeelplgtssve
lslqvsssdlpqplrsdcpgihrpdykddddk

    Sequence, based on observed residues (ATOM records):
    >6nt9C (C:)
dlpqplrsd

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6nt9D (D:)
mpqdpstrssparllipepragrarhaacvllavcfvvlflsgeplapiirsvctqlaal
qlgvllkgccclaeeifhlhsrhhgslwqvlcscfpprwylalllvggsayldppedngh
sprlaltlsclcqllvlalglqklsavevseltesskknvahglawsyyigylkvvlprl
kecmeelsrtnpmlrahrdtwklhilvplgcdiwddlekadsniqyladlpetiltragi
krrvykhslyvirdkdnklrpcvlefasplqtlcamsqddcaafsreqrleqarlfyrsl
rdilgsskecaglyrliayeepaepeshflsglilwhlqqqqreeymvqeelplgtssve
lslqvsssdlpqplrsdcpgihrpdykddddk

    Sequence, based on observed residues (ATOM records):
    >6nt9D (D:)
dlpqplrsd