PDB entry 6nq2

View 6nq2 on RCSB PDB site
Description: cryo-em structure of human tpc2 channel in the ligand-bound closed state
Deposited on 2019-01-18, released 2019-03-27
The last revision was dated 2019-11-20, with a file datestamp of 2019-11-15.
Experiment type: EM
Resolution: 3.4 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Two pore calcium channel protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: TPCN2, TPC2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NHX9
      • conflict (567)
  • Chain 'B':
    Compound: Two pore calcium channel protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: TPCN2, TPC2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NHX9
      • conflict (567)
  • Heterogens: EUJ

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6nq2A (A:)
gslemaepqaesepaaggarggggdwpaglttyrsiqvgpgaaarwdlcidqavvfieda
iqyrsinhrvdassmwlyrryysnvcqrtlsftiflilflafietpssltstadvryraa
pweppcgltesvevlcllvfaadlsvkgylfgwahfqknlwllgylvvlvvslvdwtvsl
slvcheplrirrllrpffllqnssmmkktlkcirwslpemasvglllaihlclftmfgml
lfaggkqddgqdrerltyfqnlpesltsllvllttannpdvmipaysknrayaiffivft
vigslflmnlltaiiysqfrgylmkslqtslfrrrlgtraafevlssmvgeggafpqavg
vkpqnllqvlqkvqldsshkqammekvrsygsvllsaeefqklfneldrsvvkehpprpe
yqspflqsaqflfghyyfdylgnlialanlvsicvflvldadvlpaerddfilgilncvf
ivyyllemllkvfalglrgylsypsnvfdglltvvllvleistlavyrlphpgwrpemvg
llslwdmtrmlnmlivfrflriipsmkpmavvastvlglvqnmrafggilvvvyyvfaii
ginlfrgvivalpgnsslapangsapcgsfeqleywannfddfaaalvtlwnlmvvnnwq
vfldayrrysgpwskiyfvlwwlvssviwvnlflalilenflhkwdprshlqplagtpea
tyqmtvellfrdileepeedelterlsqhphlwlcr

    Sequence, based on observed residues (ATOM records):
    >6nq2A (A:)
aarwdlcidqavvfiedaiqyrsinhrvdassmwlyrryysnvcqrtlsftiflilflaf
ietpssltstadvryraapweppcgltesvevlcllvfaadlsvkgylfgwahfqknlwl
lgylvvlvvslvdwtvslslvcheplrirrllrpffllqnssmmkktlkcirwslpemas
vglllaihlclftmfgmllfagltyfqnlpesltsllvllttannpdvmipaysknraya
iffivftvigslflmnlltaiiysqfrgylmkslqtslfrrrlgtraafevlssmvgavg
vkpqnllqvlqkvqldsshkqammekvrsygsvllsaeefqklfneldrsvvkehpprpe
yqspflqsaqflfghyyfdylgnlialanlvsicvflvldadvlpaerddfilgilncvf
ivyyllemllkvfalglrgylsypsnvfdglltvvllvleistlavyrlslwdmtrmlnm
livfrflriipsmkpmavvastvlglvqnmrafggilvvvyyvfaiiginlfrgvivals
apcgsfeqleywannfddfaaalvtlwnlmvvnnwqvfldayrrysgpwskiyfvlwwlv
ssviwvnlflalilenflhkw

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6nq2B (B:)
gslemaepqaesepaaggarggggdwpaglttyrsiqvgpgaaarwdlcidqavvfieda
iqyrsinhrvdassmwlyrryysnvcqrtlsftiflilflafietpssltstadvryraa
pweppcgltesvevlcllvfaadlsvkgylfgwahfqknlwllgylvvlvvslvdwtvsl
slvcheplrirrllrpffllqnssmmkktlkcirwslpemasvglllaihlclftmfgml
lfaggkqddgqdrerltyfqnlpesltsllvllttannpdvmipaysknrayaiffivft
vigslflmnlltaiiysqfrgylmkslqtslfrrrlgtraafevlssmvgeggafpqavg
vkpqnllqvlqkvqldsshkqammekvrsygsvllsaeefqklfneldrsvvkehpprpe
yqspflqsaqflfghyyfdylgnlialanlvsicvflvldadvlpaerddfilgilncvf
ivyyllemllkvfalglrgylsypsnvfdglltvvllvleistlavyrlphpgwrpemvg
llslwdmtrmlnmlivfrflriipsmkpmavvastvlglvqnmrafggilvvvyyvfaii
ginlfrgvivalpgnsslapangsapcgsfeqleywannfddfaaalvtlwnlmvvnnwq
vfldayrrysgpwskiyfvlwwlvssviwvnlflalilenflhkwdprshlqplagtpea
tyqmtvellfrdileepeedelterlsqhphlwlcr

    Sequence, based on observed residues (ATOM records):
    >6nq2B (B:)
aarwdlcidqavvfiedaiqyrsinhrvdassmwlyrryysnvcqrtlsftiflilflaf
ietpssltstadvryraapweppcgltesvevlcllvfaadlsvkgylfgwahfqknlwl
lgylvvlvvslvdwtvslslvcheplrirrllrpffllqnssmmkktlkcirwslpemas
vglllaihlclftmfgmllfagltyfqnlpesltsllvllttannpdvmipaysknraya
iffivftvigslflmnlltaiiysqfrgylmkslqtslfrrrlgtraafevlssmvgavg
vkpqnllqvlqkvqldsshkqammekvrsygsvllsaeefqklfneldrsvvkehpprpe
yqspflqsaqflfghyyfdylgnlialanlvsicvflvldadvlpaerddfilgilncvf
ivyyllemllkvfalglrgylsypsnvfdglltvvllvleistlavyrlslwdmtrmlnm
livfrflriipsmkpmavvastvlglvqnmrafggilvvvyyvfaiiginlfrgvivals
apcgsfeqleywannfddfaaalvtlwnlmvvnnwqvfldayrrysgpwskiyfvlwwlv
ssviwvnlflalilenflhkw