PDB entry 6npu

View 6npu on RCSB PDB site
Description: C-abl Kinase domain with the activator(cmpd29), N-(1-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)acetamide
Class: transferase
Keywords: activator, kinase, allosteric, SIGNALING PROTEIN, TRANSFERASE
Deposited on 2019-01-18, released 2019-03-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-13, with a file datestamp of 2019-03-08.
Experiment type: XRAY
Resolution: 2.33 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1, ABL, JTK7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6npua1, d6npua2
  • Chain 'B':
    Compound: Tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1, ABL, JTK7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6npub1, d6npub2
  • Heterogens: STI, KWV, SO4, GOL, 2PE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6npuA (A:)
mhhhhhhenlyfqgspnydkwemertditmkhklgggqygevyegvwkkysltvavktlk
edtmeveeflkeaavmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqe
vnavvllymatqissameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtyt
ahagakfpikwtapeslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellek
dyrmerpegcpekvyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgk

    Sequence, based on observed residues (ATOM records): (download) 
    >6npuA (A:)
ydkwemertditmkhklgggqygevyegvwkkysltvavktlkveeflkeaavmkeikhp
nlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissameylek
knfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkf
siksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracw
qwnpsdrpsfaeihqafetmfqes

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6npuB (B:)
mhhhhhhenlyfqgspnydkwemertditmkhklgggqygevyegvwkkysltvavktlk
edtmeveeflkeaavmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqe
vnavvllymatqissameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtyt
ahagakfpikwtapeslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellek
dyrmerpegcpekvyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgk

    Sequence, based on observed residues (ATOM records): (download) 
    >6npuB (B:)
dkwemertditmkhklgggqygevyegvwkkysltvavktlveeflkeaavmkeikhpnl
vqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissameylekkn
fihrdlaarnclvgenhlvkvadfgakfpikwtapeslaynkfsiksdvwafgvllweia
tygmspypgidlsqvyellekdyrmerpegcpekvyelmracwqwnpsdrpsfaeihqaf
etmfqessisdevekel