PDB entry 6no7

View 6no7 on RCSB PDB site
Description: crystal structure of the full-length wild-type pka ria holoenzyme
Deposited on 2019-01-15, released 2019-07-24
The last revision was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 3.55 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: cAMP-dependent protein kinase type I-alpha regulatory subunit
    Species: Bos taurus [TaxId:9913]
    Gene: PRKAR1A
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: cAMP-dependent protein kinase type I-alpha regulatory subunit
    Species: Bos taurus [TaxId:9913]
    Gene: PRKAR1A
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: cAMP-dependent protein kinase type I-alpha regulatory subunit
    Species: Bos taurus [TaxId:9913]
    Gene: PRKAR1A
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: cAMP-dependent protein kinase type I-alpha regulatory subunit
    Species: Bos taurus [TaxId:9913]
    Gene: PRKAR1A
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MG, ATP

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6no7A (A:)
gnaaaakkgseqesvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlv
khketgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvpggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
qvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records):
    >6no7A (A:)
vkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlvkhketgnhyamkil
dkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfshlrr
igrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkgr
twtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsgk
vrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveapf
ipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6no7B (B:)
masgttaseeerslrecelyvqkhniqallkdsivqlctarperpmaflreyfeklekee
akqiqnlqkagsradsredeisppppnpvvkgrrrrgaisaevyteedaasyvrkvipkd
yktmaalakaieknvlfshlddnersdifdamfpvsfiagetviqqgdegdnfyvidqge
mdvyvnnewatsvgeggsfgelaliygtpraatvkaktnvklwgidrdsyrrilmgstlr
krkmyeeflskvsilesldkwerltvadalepvqfedgqkivvqgepgdeffiilegsaa
vlqrrseneefvevgrlgpsdyfgeiallmnrpraatvvargplkcvkldrprfervlgp
csdilkrniqqynsfvslsv

    Sequence, based on observed residues (ATOM records):
    >6no7B (B:)
rrrrgaisaevyteedaasyvrkvipkdyktmaalakaieknvlfshlddnersdifdam
fpvsfiagetviqqgdegdnfyvidqgemdvyvnnewatsvgeggsfgelaliygtpraa
tvkaktnvklwgidrdsyrrilmgstlrkrkmyeeflskvsilesldkwerltvadalep
vqfedgqkivvqgepgdeffiilegsaavlqrrseneefvevgrlgpsdyfgeiallmnr
praatvvargplkcvkldrprfervlgpcsdilkrniqqynsfvs

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6no7C (C:)
gnaaaakkgseqesvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlv
khketgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvpggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
qvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records):
    >6no7C (C:)
eqesvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlvkhketgnhya
mkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfs
hlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakr
vkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyeki
vsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkv
eapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6no7D (D:)
masgttaseeerslrecelyvqkhniqallkdsivqlctarperpmaflreyfeklekee
akqiqnlqkagsradsredeisppppnpvvkgrrrrgaisaevyteedaasyvrkvipkd
yktmaalakaieknvlfshlddnersdifdamfpvsfiagetviqqgdegdnfyvidqge
mdvyvnnewatsvgeggsfgelaliygtpraatvkaktnvklwgidrdsyrrilmgstlr
krkmyeeflskvsilesldkwerltvadalepvqfedgqkivvqgepgdeffiilegsaa
vlqrrseneefvevgrlgpsdyfgeiallmnrpraatvvargplkcvkldrprfervlgp
csdilkrniqqynsfvslsv

    Sequence, based on observed residues (ATOM records):
    >6no7D (D:)
grrrrgaisaevyteedaasyvrkvipkdyktmaalakaieknvlfshlddnersdifda
mfpvsfiagetviqqgdegdnfyvidqgemdvyvnnewatsvgeggsfgelaliygtpra
atvkaktnvklwgidrdsyrrilmgstlrkrkmyeeflskvsilesldkwerltvadale
pvqfedgqkivvqgepgdeffiilegsaavlqrrseneefvevgrlgpsdyfgeiallmn
rpraatvvargplkcvkldrprfervlgpcsdilkrniqqynsfvs

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6no7E (E:)
gnaaaakkgseqesvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlv
khketgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvpggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
qvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records):
    >6no7E (E:)
qesvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlvkhketgnhyam
kildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfsh
lrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrv
kgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekiv
sgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkve
apfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6no7F (F:)
masgttaseeerslrecelyvqkhniqallkdsivqlctarperpmaflreyfeklekee
akqiqnlqkagsradsredeisppppnpvvkgrrrrgaisaevyteedaasyvrkvipkd
yktmaalakaieknvlfshlddnersdifdamfpvsfiagetviqqgdegdnfyvidqge
mdvyvnnewatsvgeggsfgelaliygtpraatvkaktnvklwgidrdsyrrilmgstlr
krkmyeeflskvsilesldkwerltvadalepvqfedgqkivvqgepgdeffiilegsaa
vlqrrseneefvevgrlgpsdyfgeiallmnrpraatvvargplkcvkldrprfervlgp
csdilkrniqqynsfvslsv

    Sequence, based on observed residues (ATOM records):
    >6no7F (F:)
rrrgaisaevyteedaasyvrkvipkdyktmaalakaieknvlfshlddnersdifdamf
pvsfiagetviqqgdegdnfyvidqgemdvyvnnewatsvgeggsfgelaliygtpraat
vkaktnvklwgidrdsyrrilmgstlrkrkmyeeflskvsilesldkwerltvadalepv
qfedgqkivvqgepgdeffiilegsaavlqrrseneefvevgrlgpsdyfgeiallmnrp
raatvvargplkcvkldrprfervlgpcsdilkrniqqynsfvs

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6no7G (G:)
gnaaaakkgseqesvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlv
khketgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvpggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
qvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records):
    >6no7G (G:)
svkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlvkhketgnhyamki
ldkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfshlr
rigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkg
rtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsg
kvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveap
fipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6no7H (H:)
masgttaseeerslrecelyvqkhniqallkdsivqlctarperpmaflreyfeklekee
akqiqnlqkagsradsredeisppppnpvvkgrrrrgaisaevyteedaasyvrkvipkd
yktmaalakaieknvlfshlddnersdifdamfpvsfiagetviqqgdegdnfyvidqge
mdvyvnnewatsvgeggsfgelaliygtpraatvkaktnvklwgidrdsyrrilmgstlr
krkmyeeflskvsilesldkwerltvadalepvqfedgqkivvqgepgdeffiilegsaa
vlqrrseneefvevgrlgpsdyfgeiallmnrpraatvvargplkcvkldrprfervlgp
csdilkrniqqynsfvslsv

    Sequence, based on observed residues (ATOM records):
    >6no7H (H:)
rrrgaisaevyteedaasyvrkvipkdyktmaalakaieknvlfshlddnersdifdamf
pvsfiagetviqqgdegdnfyvidqgemdvyvnnewatsvgeggsfgelaliygtpraat
vkaktnvklwgidrdsyrrilmgstlrkrkmyeeflskvsilesldkwerltvadalepv
qfedgqkivvqgepgdeffiilegsaavlqrrseneefvevgrlgpsdyfgeiallmnrp
raatvvargplkcvkldrprfervlgpcsdilkrniqqynsfvs