PDB entry 6niy

View 6niy on RCSB PDB site
Description: a high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs protein complex
Deposited on 2019-01-02, released 2019-01-23
The last revision was dated 2020-04-08, with a file datestamp of 2020-04-03.
Experiment type: EM
Resolution: 3.34 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: Nanobody35
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6NIY (0-End)
  • Chain 'P':
    Compound: calcitonin
    Species: Oncorhynchus sp., synthetic [TaxId:8025]
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: Calcitonin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: CALCR
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6niyA (A:)
mgclgnsktedqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkstivkqm
rilhvngfngeggeedpqaarsnsdgekatkvqdiknnlkeaietivaamsnlvppvela
npenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqyfld
kidvikqadyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqcfnd
vtaiifvvasssynmvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdllaek
vlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrhycy
phftcavdtenirrvfndcrdiiqrmhlrqyell

    Sequence, based on observed residues (ATOM records):
    >6niyA (A:)
edqrneekaqreankkiekqlqkdkqvyrathrllllgifetkfqvdkvnfhmfdvggqr
derrkwiqcfndvtaiifvvasnrlqealnlfksiwnnrwlrtisvilflndprvtraky
firdeflristasrhycyphftcenirrvfndcrdiiqrmhlrqyell

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6niyB (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >6niyB (B:)
eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
iynlknvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftghtgd
vmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafatgsd
datcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalkadrag
vlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6niyG (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records):
    >6niyG (G:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

  • Chain 'N':
    Sequence, based on SEQRES records:
    >6niyN (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvsshhhhhhepea

    Sequence, based on observed residues (ATOM records):
    >6niyN (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvss

  • Chain 'P':
    Sequence, based on SEQRES records:
    >6niyP (P:)
csnlstcvlgklsqelhklqtyprtntgsgtp

    Sequence, based on observed residues (ATOM records):
    >6niyP (P:)
csnlstcvlgklsqelhkl

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6niyR (R:)
mrftftsrclalflllnhptpilpafsnqtyptiepkpflyvvgrkkmmdaqykcydrmq
qlpayqgegpycnrtwdgwlcwddtpagvlsyqfcpdyfpdfdpsekvtkycdekgvwfk
hpennrtwsnytmcnaftpeklknayvlyylaivghslsiftlvislgifvffrslgcqr
vtlhknmfltyilnsmiiiihlvevvpngelvrrdpvsckilhffhqymmacnyfwmlce
giylhtlivvavftekqrlrwyyllgwgfplvpttihaitravyfndncwlsvethllyi
ihgpvmaalvvnfffllnivrvlvtkmretheaeshmylkavkatmilvpllgiqfvvfp
wrpsnkmlgkiydyvmhslihfqgffvatiycfcnnevqttvkrqwaqfkiqwnqrwgrr
psnrsaraaaaaaeagdipiyichqeprnepannqgeesaeiiplniieqessa

    Sequence, based on observed residues (ATOM records):
    >6niyR (R:)
tpeklknayvlyylaivghslsiftlvislgifvffrslgcqrvtlhknmfltyilnsmi
iiihlvevvsckilhffhqymmacnyfwmlcegiylhtlivvavftekqrlrwyyllgwg
fplvpttihaitravyfndncwlsvethllyiihgpvmaalvvnfffllnivrvlvtkmr
ethmylkavkatmilvpllgiqfvvfpwrpsnkmlgkiydyvmhslihfqgffvatiycf
cnnevqttvkrqwaqfkiqwn