PDB entry 6nha

View 6nha on RCSB PDB site
Description: Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody
Class: immune system
Keywords: FcRn, B2M, Circulating IgG and IgG immune complex, SYNT001, IMMUNE SYSTEM
Deposited on 2018-12-21, released 2019-12-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-15, with a file datestamp of 2020-01-10.
Experiment type: XRAY
Resolution: 2.38 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55899
      • engineered mutation (101)
    Domains in SCOPe 2.08: d6nhaa1, d6nhaa2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6nhab_
  • Chain 'H':
    Compound: SYNT001-Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6NHA (0-End)
    Domains in SCOPe 2.08: d6nhah_
  • Chain 'L':
    Compound: SYNT001-Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6NHA (0-End)
    Domains in SCOPe 2.08: d6nhal1, d6nhal2
  • Heterogens: NHE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6nhaA (A:)
aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
wekettdlrikeklfleafkalggkgpytlqgllgcelgpdatsvptakfalngeefmnf
dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
tvksgdehhyccivqhaglaqplrvelespaksenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6nhaA (A:)
hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenswyweket
tdlrikeklfleafkalggkgpytlqgllgcelgpdatsvptakfalngeefmnfdlkqg
twggdwpealaisqrwqqqdkaankeltfllfscphrlrehleewkeppsmrlkarpssp
gfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvksgdehhyc
civqhaglaqplrvel

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6nhaB (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6nhaH (H:)
qvqlvqsgaelkkpgasvklsckasgytftsygiswvkqatgqglewigeiyprsgntyy
nekfkgratltadkststaymelrslrsedsavyfcarsttvrppgiwgtgttvtvssas
tkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtktytcnvdhkpsntkvdkrvesky

    Sequence, based on observed residues (ATOM records): (download) 
    >6nhaH (H:)
qvqlvqsgaelkkpgasvklsckasgytftsygiswvkqatgqglewigeiyprsgntyy
nekfkgratltadkststaymelrslrsedsavyfcarsttvrppgiwgtgttvtvssas
tkgpsvfplapestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv
vtvpssslgtktytcnvdhkpsntkvdkrve

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6nhaL (L:)
diqmtqspsslsasvgdrvtitckasdhinnwlawyqqkpgqaprllisgatsletgvps
rfsgsgtgkdytltisslqpedfatyycqqywstpytfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6nhaL (L:)
diqmtqspsslsasvgdrvtitckasdhinnwlawyqqkpgqaprllisgatsletgvps
rfsgsgtgkdytltisslqpedfatyycqqywstpytfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg