PDB entry 6ng0

View 6ng0 on RCSB PDB site
Description: Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with sunitinib in the inactive state.
Class: transferase
Keywords: Kinase, 3D domain swap, inactive state, TRANSFERASE
Deposited on 2018-12-21, released 2019-05-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-26, with a file datestamp of 2019-06-21.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918
      • engineered mutation (172)
    Domains in SCOPe 2.08: d6ng0a_
  • Chain 'B':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918
      • engineered mutation (166)
      • engineered mutation (172)
    Domains in SCOPe 2.08: d6ng0b_
  • Heterogens: B49, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ng0A (A:)
gsmdvvdpdifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvst
lqkeililktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvc
revlqglaylhsqkkihrdikganilindagevrladfgisaqigaelarrlefigtpyw
mapevaavalkggynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlk
ekgkwsaafhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknpgkgp
sigdiedee

    Sequence, based on observed residues (ATOM records): (download) 
    >6ng0A (A:)
pdifnrdprdhydllqrlgggevfkardkvsgdlvalkmvkmepdddvstlqkeililkt
crhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglayl
hsqkkihrdikganilindagevrladfgisalarrlefigtpywmapevaavalkggyn
elcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnfikv
tltkspkkrpsatkmlshqlvsqpglnrglildlldklknpgkgpsigd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ng0B (B:)
gsmdvvdpdifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvst
lqkeililktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvc
revlqglaylhsqkkihrdikganilindagevrladfgisaqigaelarrlefigtpyw
mapevaavalkggynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlk
ekgkwsaafhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknpgkgp
sigdiedee

    Sequence, based on observed residues (ATOM records): (download) 
    >6ng0B (B:)
difnrdprdhydllqrlggevfkardkvsgdlvalkmvkddvstlqkeililktcrhani
vayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglaylhsqkki
hrdikganilindagevrladfgisaqigaelarrlefigtpywmapevaavalkggyne
lcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnfikvt
ltkspkkrpsatkmlshqlvsqpglnrglildlldklkn