PDB entry 6nfy

View 6nfy on RCSB PDB site
Description: Crystal structure of nonphosphorylated, HPK1 kinase domain in complex with sunitinib in the inactive state.
Class: transferase
Keywords: Kinase, 3D domain swap, active state, TRANSFERASE
Deposited on 2018-12-21, released 2019-05-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-26, with a file datestamp of 2019-06-21.
Experiment type: XRAY
Resolution: 2.17 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d6nfya1, d6nfya2
  • Chain 'B':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d6nfyb1, d6nfyb2
  • Heterogens: B49, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6nfyA (A:)
gsnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeililk
tcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglay
lhsqkkihrdikganilindagevrladfgisaqigatlarrlsfigtpywmapevaava
lkggynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaaf
hnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknpgkgpsigdiedee

    Sequence, based on observed residues (ATOM records): (download) 
    >6nfyA (A:)
gsnrdprdhydllqrlgggevfkardkvsgdlvalkmvkmepdddvstlqkeililktcr
hanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglaylhs
qkkihrdikganilindagevrladfgisaqigatlarrlsfigtpywmapevaavalkg
gynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnf
ikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6nfyB (B:)
gsnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeililk
tcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglay
lhsqkkihrdikganilindagevrladfgisaqigatlarrlsfigtpywmapevaava
lkggynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaaf
hnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknpgkgpsigdiedee

    Sequence, based on observed residues (ATOM records): (download) 
    >6nfyB (B:)
gsnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeililk
tcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglay
lhsqkkihrdikganilindagevrladfgisaqigatlarrlsfigtpywmapevaava
lkggynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaaf
hnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklk