PDB entry 6nfo

View 6nfo on RCSB PDB site
Description: cyclic gmp-amp synthase in complex with compound 20 inhibitor: 7- hydroxy-n-[(2s)-1-hydroxypropan-2-yl]-5-phenylpyrazolo[1,5- a]pyrimidine-3-carboxamide
Deposited on 2018-12-20, released 2019-01-23
The last revision was dated 2019-01-23, with a file datestamp of 2019-01-18.
Experiment type: XRAY
Resolution: 2.93 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cyclic GMP-AMP synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: CGAS, C6orf150, MB21D1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Cyclic GMP-AMP synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: CGAS, C6orf150, MB21D1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: KKM, ZN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6nfoA (A:)
gasklravleklklsrddistaagmvkgvvdhlllrlkcdsafrgvgllntgsyyehvki
sapnefdvmfklevpriqleeysntrayyfvkfkrnpkenplsqflegeilsaskmlskf
rkiikeeindikdtdvimkrkrggspavtllisekisvditlalesksswpastqeglri
qnwlsakvrkqlrlkpfylvpkhakegngfqeetwrlsfshiekeilnnhgksktccenk
eekccrkdclklmkylleqlkerfkdkkhldkfssyhvktaffhvctqnpqdsqwdrkdl
glcfdncvtyflqclrteklenyfipefnlfssnlidkrskefltkqieyernnefpvfd
ef

    Sequence, based on observed residues (ATOM records):
    >6nfoA (A:)
gasklravleklklsrddistaagmvkgvvdhlllrlkcdsafrgvgllntgsyyehvki
sapnefdvmfklevpriqleeysntrayyfvkfnplsqflegeilsaskmlskfrkiike
eindikdtdvimkrkpavtllisekisvditlalesksswpastqeglriqnwlsakvrk
qlrlkpfylvpkhangfqeetwrlsfshiekeilnnhgksktccenkeekccrkdclklm
kylleqlkerfkdkkhldkfssyhvktaffhvctqnpqdsqwdrkdlglcfdncvtyflq
clrteklenyfipefnlfssnlidkrskefltkqieyernnefpvfd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6nfoB (B:)
gasklravleklklsrddistaagmvkgvvdhlllrlkcdsafrgvgllntgsyyehvki
sapnefdvmfklevpriqleeysntrayyfvkfkrnpkenplsqflegeilsaskmlskf
rkiikeeindikdtdvimkrkrggspavtllisekisvditlalesksswpastqeglri
qnwlsakvrkqlrlkpfylvpkhakegngfqeetwrlsfshiekeilnnhgksktccenk
eekccrkdclklmkylleqlkerfkdkkhldkfssyhvktaffhvctqnpqdsqwdrkdl
glcfdncvtyflqclrteklenyfipefnlfssnlidkrskefltkqieyernnefpvfd
ef

    Sequence, based on observed residues (ATOM records):
    >6nfoB (B:)
gasklravleklklsrddistaagmvkgvvdhlllrlkcdsafrgvgllntgsyyehvki
sapnefdvmfklevpriqleeysntrayyfvkfknpkenplsqflegeilsaskmlskfr
kiikeeindikdtdvimkrkrggspavtllisekisvditlalesksswpastqeglriq
nwlsakvrkqlrlkpfylvpkhakgfqeetwrlsfshiekeilnnhgksktccenkeekc
crkdclklmkylleqlkerfkdkkhldkfssyhvktaffhvctqnpqdsqwdrkdlglcf
dncvtyflqclrteklenyfipefnlfssnlidkrskefltkqieyernnefpvfd