PDB entry 6ncn

View 6ncn on RCSB PDB site
Description: Fragment-based Discovery of an apoE4 Stabilizer
Class: lipid transport
Keywords: Lipid Binding Lipid Transport, LIPID TRANSPORT
Deposited on 2018-12-11, released 2019-04-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 1.82 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: apolipoprotein e
    Species: Homo sapiens [TaxId:9606]
    Gene: Apoe
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02649 (Start-181)
      • variant (131)
      • expression tag (182-183)
    Domains in SCOPe 2.08: d6ncna1, d6ncna2
  • Heterogens: KJM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ncnA (A:)
gsshhhhhhssglvprgshmkveqavetepepelrqqtewqsgqrwelalgrfwdylrwv
qtlseqvqeellssqvtqelralmdetmkelkaykseleeqltpvaeetrarlskelqaa
qarlgadmedvrgrlvqyrgevqamlgqsteelrvrlashlrklrkrllrdaddlqkrla
vyqag

    Sequence, based on observed residues (ATOM records): (download) 
    >6ncnA (A:)
qrwelalgrfwdylrwvqtlseqvqeellssqvtqelralmdetmkelkaykseleeqlt
pvaeetrarlskelqaaqarlgadmedvrgrlvqyrgevqamlgqsteelrvrlashlrk
lrkrllrdaddlqkrlavyqa