PDB entry 6naw

View 6naw on RCSB PDB site
Description: Crystal structure of Neisseria meningitidis ClpP E58A activated mutant
Class: hydrolase
Keywords: Serine protease, antibiotic, HYDROLASE
Deposited on 2018-12-06, released 2019-11-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-29, with a file datestamp of 2020-01-24.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawa_
  • Chain 'B':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawb_
  • Chain 'C':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawc_
  • Chain 'D':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawd_
  • Chain 'E':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawe_
  • Chain 'F':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawf_
  • Chain 'G':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawg_
  • Chain 'H':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawh_
  • Chain 'I':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawi_
  • Chain 'J':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawj_
  • Chain 'K':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawk_
  • Chain 'L':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawl_
  • Chain 'M':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawm_
  • Chain 'N':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Neisseria meningitidis [TaxId:487]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot I4E574
      • engineered mutation (70)
    Domains in SCOPe 2.08: d6nawn_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6nawA (A:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawA (A:)
vptvfdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvta
gmsiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqplgqasdie
iharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6nawB (B:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawB (B:)
vptvfdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvta
gmsiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqpligqasdi
eiharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenra

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6nawC (C:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawC (C:)
diysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvtagmsiy
dtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqplisggqasdieih
arellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenra

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6nawD (D:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawD (D:)
vptvfdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvta
gmsiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqpliggqasd
ieiharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenra

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6nawE (E:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawE (E:)
vptvfdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvta
gmsiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqpliggqasd
ieiharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilen

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6nawF (F:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawF (F:)
vptvfdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvta
gmsiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqpliggqasd
ieiharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenra

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6nawG (G:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawG (G:)
vptvfdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvta
gmsiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqplisgggqa
sdieiharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenr
asl

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6nawH (H:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawH (H:)
lvptvdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvta
gmsiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqpliggqasd
ieiharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenras

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6nawI (I:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawI (I:)
lvptvdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvta
gmsiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqpliggqasd
ieiharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenr

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6nawJ (J:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawJ (J:)
vptvdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvtag
msiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqpliggqasdi
eiharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenrasl

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >6nawK (K:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawK (K:)
vptvfdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvta
gmsiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqplisggggq
asdieiharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilen
ras

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6nawL (L:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawL (L:)
diysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvtagmsiy
dtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqplisggqasdieih
arellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenra

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >6nawM (M:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawM (M:)
vptvfdiysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvta
gmsiydtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqpliggqasd
ieiharellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenr

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >6nawN (N:)
hhhhhhenlyfqgmsfdnylvptvieqsgrgerafdiysrllkerivflvgpvtdesanl
vvaqllflesanpdkdiffyinspggsvtagmsiydtmnfikpdvstlclgqaasmgafl
lsagekgkrfalpnsrimihqplisgglggqasdieiharellkikeklnrlmakhcdrd
ladlerdtdrdnfmsaeeakeyglidqilenraslrl

    Sequence, based on observed residues (ATOM records): (download) 
    >6nawN (N:)
diysrllkerivflvgpvtdesanlvvaqllflesanpdkdiffyinspggsvtagmsiy
dtmnfikpdvstlclgqaasmgafllsagekgkrfalpnsrimihqplilggqasdieih
arellkikeklnrlmakhcdrdladlerdtdrdnfmsaeeakeyglidqilenras