PDB entry 6n81

View 6n81 on RCSB PDB site
Description: Crystal structure of GII.4 2002 norovirus P domain in complex with cross-reactive human antibody A1227
Class: immune system
Keywords: Norovirus, human antibody, complex, Fab, IMMUNE SYSTEM
Deposited on 2018-11-28, released 2019-06-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-03, with a file datestamp of 2019-06-28.
Experiment type: XRAY
Resolution: 2.58 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Major capsid protein
    Species: Norovirus Hu/GII.4/Farmington Hills/2004/USA [TaxId:1182143]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6n81a_
  • Chain 'B':
    Compound: Major capsid protein
    Species: Norovirus Hu/GII.4/Farmington Hills/2004/USA [TaxId:1182143]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6n81b_
  • Chain 'C':
    Compound: A1227 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6N81 (0-End)
    Domains in SCOPe 2.08: d6n81c_
  • Chain 'D':
    Compound: A1227 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6N81 (0-End)
    Domains in SCOPe 2.08: d6n81d1, d6n81d2
  • Chain 'H':
    Compound: A1227 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6N81 (0-End)
    Domains in SCOPe 2.08: d6n81h_
  • Chain 'L':
    Compound: A1227 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6N81 (0-End)
    Domains in SCOPe 2.08: d6n81l1, d6n81l2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6n81A (A:)
gpskpftvpiltveemtnsrfpipleklftgpsgafvvqpqngrcttdgvllgttqlspv
nictfrgdvthiagthnytmnlasqnwnnydpteeipaplgtpdfvgriqgmltqttrgd
gstrghkatvstgdvhftpklgsiqfntdtnndfetgqntkftpvgvvqdgngahqnepq
qwvlpsysgrtghnvhlapavaptfpgeqllffrstmpgcsgypnmnldcllpqewvqhf
yqeaapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdswv
nqfytlapm

    Sequence, based on observed residues (ATOM records): (download) 
    >6n81A (A:)
kpftvpiltveemtnsrfpipleklftgpsgafvvqpqngrcttdgvllgttqlspvnic
tfrgdvthiagthnytmnlasqnwnnydpteeipaplgtpdfvgriqgmltqttrgdgst
rghkatvstgdvhftpklgsiqfntdtnndfetgqntkftpvgvvqdgngahqnepqqwv
lpsysgrtghnvhlapavaptfpgeqllffrstmpgcsgypnmnldcllpqewvqhfyqe
aapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdswvnqf
ytlapm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6n81B (B:)
gpskpftvpiltveemtnsrfpipleklftgpsgafvvqpqngrcttdgvllgttqlspv
nictfrgdvthiagthnytmnlasqnwnnydpteeipaplgtpdfvgriqgmltqttrgd
gstrghkatvstgdvhftpklgsiqfntdtnndfetgqntkftpvgvvqdgngahqnepq
qwvlpsysgrtghnvhlapavaptfpgeqllffrstmpgcsgypnmnldcllpqewvqhf
yqeaapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdswv
nqfytlapm

    Sequence, based on observed residues (ATOM records): (download) 
    >6n81B (B:)
kpftvpiltveemtnsrfpipleklftgpsgafvvqpqngrcttdgvllgttqlspvnic
tfrgdvthiagthnytmnlasqnwnnydpteeipaplgtpdfvgriqgmltqttrgdgst
rghkatvstgdvhftpklgsiqfntdtnndfetgqntkftpvgvvqdgngahqnepqqwv
lpsysgrtghnvhlapavaptfpgeqllffrstmpgcsgypnmnldcllpqewvqhfyqe
aapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdswvnqf
ytlapm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6n81C (C:)
qvqlvqsgggmvqpggslslscaasgftlsnyamtwvrqapgkglewvssiggsggttyy
adsvkgrftisrdssmntlylqmsnlragdtavyycakdktrtlrlgysgmdvwgqgttv
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkglevlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6n81C (C:)
qvqlvqsgggmvqpggslslscaasgftlsnyamtwvrqapgkglewvssiggsggttyy
adsvkgrftisrdssmntlylqmsnlragdtavyycakdktrtlrlgysgmdvwgqgttv
tvssastkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6n81D (D:)
dirltqspsslsasvgdrvtitcrasqsissylnwyqqkpgkapdlliygasslqsgvps
rfsgsgsgtdftltisslqpedfgnyycqqsfstprtfgqgtkvelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6n81D (D:)
dirltqspsslsasvgdrvtitcrasqsissylnwyqqkpgkapdlliygasslqsgvps
rfsgsgsgtdftltisslqpedfgnyycqqsfstprtfgqgtkvelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnr

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6n81H (H:)
qvqlvqsgggmvqpggslslscaasgftlsnyamtwvrqapgkglewvssiggsggttyy
adsvkgrftisrdssmntlylqmsnlragdtavyycakdktrtlrlgysgmdvwgqgttv
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkglevlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6n81H (H:)
qvqlvqsgggmvqpggslslscaasgftlsnyamtwvrqapgkglewvssiggsggttyy
adsvkgrftisrdssmntlylqmsnlragdtavyycakdktrtlrlgysgmdvwgqgttv
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6n81L (L:)
dirltqspsslsasvgdrvtitcrasqsissylnwyqqkpgkapdlliygasslqsgvps
rfsgsgsgtdftltisslqpedfgnyycqqsfstprtfgqgtkvelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6n81L (L:)
dirltqspsslsasvgdrvtitcrasqsissylnwyqqkpgkapdlliygasslqsgvps
rfsgsgsgtdftltisslqpedfgnyycqqsfstprtfgqgtkvelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnr