PDB entry 6n7y

View 6n7y on RCSB PDB site
Description: Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-102
Class: transferase/transferase inhibitor
Keywords: Transferase, Transferase-Transferase Inhibitor complex
Deposited on 2018-11-28, released 2019-11-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-27, with a file datestamp of 2019-11-22.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'F':
    Compound: farnesyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6n7yf_
  • Heterogens: GOL, KFA, PO4, HOH

PDB Chain Sequences:

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6n7yF (F:)
mgsshhhhhhssgrenlyfqghmngdqnsdvyaqekqdfvqhfsqivrvltedemghpei
gdaiarlkevleynaiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaf
flvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnlie
lflqssyqteigqtldlltapqgnvdlvrftekryksivkyktafysfylpiaaamymag
idgekehanakkillemgeffqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqra
tpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplpp
avflglarkiykrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >6n7yF (F:)
yaqekqdfvqhfsqivrvlteghpeigdaiarlkevleynaiggkynrgltvvvafrelv
eprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldainda
nlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapnvdlvrftekryk
sivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgdpsv
tgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpavf
lqyeedsyshimalieqyaaplppavflglarkiyk