PDB entry 6n7g

View 6n7g on RCSB PDB site
Description: cryo-em structure of tetrameric ptch1 in complex with shhnp (form i)
Deposited on 2018-11-27, released 2019-05-29
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: EM
Resolution: 6.8 Å
R-factor: N/A
AEROSPACI score: 0.03 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein patched homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTCH1, PTCH
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Protein patched homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTCH1, PTCH
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Sonic hedgehog protein
    Species: Homo sapiens [TaxId:9606]
    Gene: SHH
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Protein patched homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTCH1, PTCH
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Protein patched homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTCH1, PTCH
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Sonic hedgehog protein
    Species: Homo sapiens [TaxId:9606]
    Gene: SHH
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, CLR, ZN, CA, PLM

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6n7gA (A:)
madykddddksgpdevdasgrmasagnaaepqdrggggsgcigapgrpagggrrrrtggl
rraaapdrdylhrpsycdaafaleqiskgkatgrkaplwlrakfqrllfklgcyiqkncg
kflvvgllifgafavglkaanletnveelwvevggrvsrelnytrqkigeeamfnpqlmi
qtpkeeganvltteallqhldsalqasrvhvymynrqwklehlcyksgelitetgymdqi
ieylypcliitpldcfwegaklqsgtayllgkpplrwtnfdplefleelkkinyqvdswe
emlnkaevghgymdrpclnpadpdcpatapnknstkpldmalvlnggchglsrkymhwqe
elivggtvknstgklvsahalqtmfqlmtpkqmyehfkgyeyvshinwnedkaaaileaw
qrtyvevvhqsvaqnstqkvlsfttttlddilksfsdvsvirvasgyllmlayacltmlr
wdcsksqgavglagvllvalsvaaglglcsligisfnaattqvlpflalgvgvddvflla
hafsetgqnkripfedrtgeclkrtgasvaltsisnvtaffmaalipipalrafslqaav
vvvfnfamvllifpailsmdlyrredrrldifccftspcvsrviqvepqaytdthdntry
sppppysshsfahetqitmqstvqlrteydphthvyyttaeprseisvqpvtvtqdtlsc
qspestsstrdllsqfsdsslhcleppctkwtlssfaekhyapfllkpkakvvviflflg
llgvslygttrvrdgldltdivpretreydfiaaqfkyfsfynmyivtqkadypniqhll
ydlhrsfsnvkyvmleenkqlpkmwlhyfrdwlqglqdafdsdwetgkimpnnykngsdd
gvlaykllvqtgsrdkpidisqltkqrlvdadgiinpsafyiyltawvsndpvayaasqa
nirphrpewvhdkadympetrlripaaepieyaqfpfylnglrdtsdfveaiekvrtics
nytslglssypngypflfweqyiglrhwlllfisvvlactflvcavfllnpwtagiivmv
lalmtvelfgmmgligiklsavpvviliasvgigveftvhvalafltaigdknrravlal
ehmfapvldgavstllgvlmlagsefdfivryffavlailtilgvlnglvllpvllsffg
pypevspanglnrlptpspepppsvvrfamppghthsgsdssdseyssqttvsglseelr
hyeaqqgaggpahqviveatenpvfahstvvhpesrhhppsnprqqphldsgslppgrqg
qqprrdlegsdevdavegshhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6n7gA (A:)
rkaplwlrakfqrllfklgcyiqkncgkflvvgllifgafavglkaanletnveelwvev
ggrvsrelnytrqkigeeamfnpqlmiqtpkeeganvltteallqhldsalqasrvhvym
ynrqwklehlcyksgelitetgymdqiieylypcliitpldcfwegaklqsgtayllgkp
plrwtnfdplefleelkkinyqvdsweemlnkaevghgymdrpclnpadpdcpatapnkn
stkpldmalvlnggchglsrkymhwqeelivggtvknstgklvsahalqtmfqlmtpkqm
yehfkgyeyvshinwnedkaaaileawqrtyvevvhqsvaqnstqkvlsfttttlddilk
sfsdvsvirvasgyllmlayacltmlrwdcsksqgavglagvllvalsvaaglglcslig
isfnaattqvlpflalgvgvddvfllahafsetgqnkripfedrtgeclkrtgasvalts
isnvtaffmaalipipalrafslqaavvvvfnfamvllifpailsmdlyrredrkwtlss
faekhyapfllkpkakvvviflflgllgvslygttrvrdgldltdivpretreydfiaaq
fkyfsfynmyivtqkadypniqhllydlhrsfsnvkyvmleenkqlpkmwlhyfrdwlqg
lqdafdsdwetgkimpnnykngsddgvlaykllvqtgsrdkpidisqltkqrlvdadgii
npsafyiyltawvsndpvayaasqanirphrpewvhdkadympetrlripaaepieyaqf
pfylnglrdtsdfveaiekvrticsnytslglssypngypflfweqyiglrhwlllfisv
vlactflvcavfllnpwtagiivmvlalmtvelfgmmgligiklsavpvviliasvgigv
eftvhvalafltaigdknrravlalehmfapvldgavstllgvlmlagsefdfivryffa
vlailtilgvlnglvllpvllsffgpypevs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6n7gB (B:)
madykddddksgpdevdasgrmasagnaaepqdrggggsgcigapgrpagggrrrrtggl
rraaapdrdylhrpsycdaafaleqiskgkatgrkaplwlrakfqrllfklgcyiqkncg
kflvvgllifgafavglkaanletnveelwvevggrvsrelnytrqkigeeamfnpqlmi
qtpkeeganvltteallqhldsalqasrvhvymynrqwklehlcyksgelitetgymdqi
ieylypcliitpldcfwegaklqsgtayllgkpplrwtnfdplefleelkkinyqvdswe
emlnkaevghgymdrpclnpadpdcpatapnknstkpldmalvlnggchglsrkymhwqe
elivggtvknstgklvsahalqtmfqlmtpkqmyehfkgyeyvshinwnedkaaaileaw
qrtyvevvhqsvaqnstqkvlsfttttlddilksfsdvsvirvasgyllmlayacltmlr
wdcsksqgavglagvllvalsvaaglglcsligisfnaattqvlpflalgvgvddvflla
hafsetgqnkripfedrtgeclkrtgasvaltsisnvtaffmaalipipalrafslqaav
vvvfnfamvllifpailsmdlyrredrrldifccftspcvsrviqvepqaytdthdntry
sppppysshsfahetqitmqstvqlrteydphthvyyttaeprseisvqpvtvtqdtlsc
qspestsstrdllsqfsdsslhcleppctkwtlssfaekhyapfllkpkakvvviflflg
llgvslygttrvrdgldltdivpretreydfiaaqfkyfsfynmyivtqkadypniqhll
ydlhrsfsnvkyvmleenkqlpkmwlhyfrdwlqglqdafdsdwetgkimpnnykngsdd
gvlaykllvqtgsrdkpidisqltkqrlvdadgiinpsafyiyltawvsndpvayaasqa
nirphrpewvhdkadympetrlripaaepieyaqfpfylnglrdtsdfveaiekvrtics
nytslglssypngypflfweqyiglrhwlllfisvvlactflvcavfllnpwtagiivmv
lalmtvelfgmmgligiklsavpvviliasvgigveftvhvalafltaigdknrravlal
ehmfapvldgavstllgvlmlagsefdfivryffavlailtilgvlnglvllpvllsffg
pypevspanglnrlptpspepppsvvrfamppghthsgsdssdseyssqttvsglseelr
hyeaqqgaggpahqviveatenpvfahstvvhpesrhhppsnprqqphldsgslppgrqg
qqprrdlegsdevdavegshhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6n7gB (B:)
plwlrakfqrllfklgcyiqkncgkflvvgllifgafavglkaanletnveelwvevggr
vsrelnytrqkigeeamfnpqlmiqtpkeeganvltteallqhldsalqasrvhvymynr
qwklehlcyksgelitetgymdqiieylypcliitpldcfwegaklqsgtayllgkpplr
wtnfdplefleelkkinyqvdsweemlnkaevghgymdrpclnpadpdcpatapnknstk
pldmalvlnggchglsrkymhwqeelivggtvknstgklvsahalqtmfqlmtpkqmyeh
fkgyeyvshinwnedkaaaileawqrtyvevvhqsvaqnstqkvlsfttttlddilksfs
dvsvirvasgyllmlayacltmlrwdcsksqgavglagvllvalsvaaglglcsligisf
naattqvlpflalgvgvddvfllahafsetgqnkripfedrtgeclkrtgasvaltsisn
vtaffmaalipipalrafslqaavvvvfnfamvllifpailsmdlyrredrrlditlssf
aekhyapfllkpkakvvviflflgllgvslygttrvrdgldltdivpretreydfiaaqf
kyfsfynmyivtqkadypniqhllydlhrsfsnvkyvmleenkqlpkmwlhyfrdwlqgl
qdafdsdwetgkimpnnykngsddgvlaykllvqtgsrdkpidisqltkqrlvdadgiin
psafyiyltawvsndpvayaasqanirphrpewvhdkadympetrlripaaepieyaqfp
fylnglrdtsdfveaiekvrticsnytslglssypngypflfweqyiglrhwlllfisvv
lactflvcavfllnpwtagiivmvlalmtvelfgmmgligiklsavpvviliasvgigve
ftvhvalafltaigdknrravlalehmfapvldgavstllgvlmlagsefdfivryffav
lailtilgvlnglvllpvllsffgpype

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6n7gC (C:)
cgpgrgfgkrrhpkkltplaykqfipnvaektlgasgryegkisrnserfkeltpnynpd
iifkdeentgadrlmtqrckdklnalaisvmnqwpgvklrvtegwdedghhseeslhyeg
ravdittsdrdrskygmlarlaveagfdwvyyeskahihcsvkaensvaaksgg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6n7gD (D:)
madykddddksgpdevdasgrmasagnaaepqdrggggsgcigapgrpagggrrrrtggl
rraaapdrdylhrpsycdaafaleqiskgkatgrkaplwlrakfqrllfklgcyiqkncg
kflvvgllifgafavglkaanletnveelwvevggrvsrelnytrqkigeeamfnpqlmi
qtpkeeganvltteallqhldsalqasrvhvymynrqwklehlcyksgelitetgymdqi
ieylypcliitpldcfwegaklqsgtayllgkpplrwtnfdplefleelkkinyqvdswe
emlnkaevghgymdrpclnpadpdcpatapnknstkpldmalvlnggchglsrkymhwqe
elivggtvknstgklvsahalqtmfqlmtpkqmyehfkgyeyvshinwnedkaaaileaw
qrtyvevvhqsvaqnstqkvlsfttttlddilksfsdvsvirvasgyllmlayacltmlr
wdcsksqgavglagvllvalsvaaglglcsligisfnaattqvlpflalgvgvddvflla
hafsetgqnkripfedrtgeclkrtgasvaltsisnvtaffmaalipipalrafslqaav
vvvfnfamvllifpailsmdlyrredrrldifccftspcvsrviqvepqaytdthdntry
sppppysshsfahetqitmqstvqlrteydphthvyyttaeprseisvqpvtvtqdtlsc
qspestsstrdllsqfsdsslhcleppctkwtlssfaekhyapfllkpkakvvviflflg
llgvslygttrvrdgldltdivpretreydfiaaqfkyfsfynmyivtqkadypniqhll
ydlhrsfsnvkyvmleenkqlpkmwlhyfrdwlqglqdafdsdwetgkimpnnykngsdd
gvlaykllvqtgsrdkpidisqltkqrlvdadgiinpsafyiyltawvsndpvayaasqa
nirphrpewvhdkadympetrlripaaepieyaqfpfylnglrdtsdfveaiekvrtics
nytslglssypngypflfweqyiglrhwlllfisvvlactflvcavfllnpwtagiivmv
lalmtvelfgmmgligiklsavpvviliasvgigveftvhvalafltaigdknrravlal
ehmfapvldgavstllgvlmlagsefdfivryffavlailtilgvlnglvllpvllsffg
pypevspanglnrlptpspepppsvvrfamppghthsgsdssdseyssqttvsglseelr
hyeaqqgaggpahqviveatenpvfahstvvhpesrhhppsnprqqphldsgslppgrqg
qqprrdlegsdevdavegshhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6n7gD (D:)
rkaplwlrakfqrllfklgcyiqkncgkflvvgllifgafavglkaanletnveelwvev
ggrvsrelnytrqkigeeamfnpqlmiqtpkeeganvltteallqhldsalqasrvhvym
ynrqwklehlcyksgelitetgymdqiieylypcliitpldcfwegaklqsgtayllgkp
plrwtnfdplefleelkkinyqvdsweemlnkaevghgymdrpclnpadpdcpatapnkn
stkpldmalvlnggchglsrkymhwqeelivggtvknstgklvsahalqtmfqlmtpkqm
yehfkgyeyvshinwnedkaaaileawqrtyvevvhqsvaqnstqkvlsfttttlddilk
sfsdvsvirvasgyllmlayacltmlrwdcsksqgavglagvllvalsvaaglglcslig
isfnaattqvlpflalgvgvddvfllahafsetgqnkripfedrtgeclkrtgasvalts
isnvtaffmaalipipalrafslqaavvvvfnfamvllifpailsmdlyrredrkwtlss
faekhyapfllkpkakvvviflflgllgvslygttrvrdgldltdivpretreydfiaaq
fkyfsfynmyivtqkadypniqhllydlhrsfsnvkyvmleenkqlpkmwlhyfrdwlqg
lqdafdsdwetgkimpnnykngsddgvlaykllvqtgsrdkpidisqltkqrlvdadgii
npsafyiyltawvsndpvayaasqanirphrpewvhdkadympetrlripaaepieyaqf
pfylnglrdtsdfveaiekvrticsnytslglssypngypflfweqyiglrhwlllfisv
vlactflvcavfllnpwtagiivmvlalmtvelfgmmgligiklsavpvviliasvgigv
eftvhvalafltaigdknrravlalehmfapvldgavstllgvlmlagsefdfivryffa
vlailtilgvlnglvllpvllsffgpypevs

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6n7gE (E:)
madykddddksgpdevdasgrmasagnaaepqdrggggsgcigapgrpagggrrrrtggl
rraaapdrdylhrpsycdaafaleqiskgkatgrkaplwlrakfqrllfklgcyiqkncg
kflvvgllifgafavglkaanletnveelwvevggrvsrelnytrqkigeeamfnpqlmi
qtpkeeganvltteallqhldsalqasrvhvymynrqwklehlcyksgelitetgymdqi
ieylypcliitpldcfwegaklqsgtayllgkpplrwtnfdplefleelkkinyqvdswe
emlnkaevghgymdrpclnpadpdcpatapnknstkpldmalvlnggchglsrkymhwqe
elivggtvknstgklvsahalqtmfqlmtpkqmyehfkgyeyvshinwnedkaaaileaw
qrtyvevvhqsvaqnstqkvlsfttttlddilksfsdvsvirvasgyllmlayacltmlr
wdcsksqgavglagvllvalsvaaglglcsligisfnaattqvlpflalgvgvddvflla
hafsetgqnkripfedrtgeclkrtgasvaltsisnvtaffmaalipipalrafslqaav
vvvfnfamvllifpailsmdlyrredrrldifccftspcvsrviqvepqaytdthdntry
sppppysshsfahetqitmqstvqlrteydphthvyyttaeprseisvqpvtvtqdtlsc
qspestsstrdllsqfsdsslhcleppctkwtlssfaekhyapfllkpkakvvviflflg
llgvslygttrvrdgldltdivpretreydfiaaqfkyfsfynmyivtqkadypniqhll
ydlhrsfsnvkyvmleenkqlpkmwlhyfrdwlqglqdafdsdwetgkimpnnykngsdd
gvlaykllvqtgsrdkpidisqltkqrlvdadgiinpsafyiyltawvsndpvayaasqa
nirphrpewvhdkadympetrlripaaepieyaqfpfylnglrdtsdfveaiekvrtics
nytslglssypngypflfweqyiglrhwlllfisvvlactflvcavfllnpwtagiivmv
lalmtvelfgmmgligiklsavpvviliasvgigveftvhvalafltaigdknrravlal
ehmfapvldgavstllgvlmlagsefdfivryffavlailtilgvlnglvllpvllsffg
pypevspanglnrlptpspepppsvvrfamppghthsgsdssdseyssqttvsglseelr
hyeaqqgaggpahqviveatenpvfahstvvhpesrhhppsnprqqphldsgslppgrqg
qqprrdlegsdevdavegshhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6n7gE (E:)
plwlrakfqrllfklgcyiqkncgkflvvgllifgafavglkaanletnveelwvevggr
vsrelnytrqkigeeamfnpqlmiqtpkeeganvltteallqhldsalqasrvhvymynr
qwklehlcyksgelitetgymdqiieylypcliitpldcfwegaklqsgtayllgkpplr
wtnfdplefleelkkinyqvdsweemlnkaevghgymdrpclnpadpdcpatapnknstk
pldmalvlnggchglsrkymhwqeelivggtvknstgklvsahalqtmfqlmtpkqmyeh
fkgyeyvshinwnedkaaaileawqrtyvevvhqsvaqnstqkvlsfttttlddilksfs
dvsvirvasgyllmlayacltmlrwdcsksqgavglagvllvalsvaaglglcsligisf
naattqvlpflalgvgvddvfllahafsetgqnkripfedrtgeclkrtgasvaltsisn
vtaffmaalipipalrafslqaavvvvfnfamvllifpailsmdlyrredrrlditlssf
aekhyapfllkpkakvvviflflgllgvslygttrvrdgldltdivpretreydfiaaqf
kyfsfynmyivtqkadypniqhllydlhrsfsnvkyvmleenkqlpkmwlhyfrdwlqgl
qdafdsdwetgkimpnnykngsddgvlaykllvqtgsrdkpidisqltkqrlvdadgiin
psafyiyltawvsndpvayaasqanirphrpewvhdkadympetrlripaaepieyaqfp
fylnglrdtsdfveaiekvrticsnytslglssypngypflfweqyiglrhwlllfisvv
lactflvcavfllnpwtagiivmvlalmtvelfgmmgligiklsavpvviliasvgigve
ftvhvalafltaigdknrravlalehmfapvldgavstllgvlmlagsefdfivryffav
lailtilgvlnglvllpvllsffgpype

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >6n7gF (F:)
cgpgrgfgkrrhpkkltplaykqfipnvaektlgasgryegkisrnserfkeltpnynpd
iifkdeentgadrlmtqrckdklnalaisvmnqwpgvklrvtegwdedghhseeslhyeg
ravdittsdrdrskygmlarlaveagfdwvyyeskahihcsvkaensvaaksgg