PDB entry 6n7a

View 6n7a on RCSB PDB site
Description: Structure of the human JAK1 kinase domain with compound 39
Class: immune system
Keywords: jak1, il13, il-13, jak2, jak3, tyk2, immune system
Deposited on 2018-11-27, released 2019-04-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-15, with a file datestamp of 2019-05-10.
Experiment type: XRAY
Resolution: 1.33 Å
R-factor: N/A
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6n7aa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23458 (3-303)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d6n7ab1, d6n7ab2
  • Heterogens: GOL, KEV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6n7aA (A:)
gsgdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavksl
kpesggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpk
nknkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaiet
dkeyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflk
migpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfe
allk

    Sequence, based on observed residues (ATOM records): (download) 
    >6n7aA (A:)
vdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkphiadlkkeieil
rnlyhenivkykgictgiklimeflpsgslkeylpknknkinlkqqlkyavqickgmdyl
gsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyapeclm
qskfyiasdvwsfgvtlhelltycdsdsspmalflkmighgqmtvtrlvntlkegkrlpc
ppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6n7aB (B:)
gsgdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavksl
kpesggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpk
nknkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaiet
dkeyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflk
migpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfe
allk

    Sequence, based on observed residues (ATOM records): (download) 
    >6n7aB (B:)
gsgdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavksl
kphiadlkkeieilrnlyhenivkykgictgiklimeflpsgslkeylpknknkinlkqq
lkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkdd
rdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmt
vtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk