PDB entry 6n6u

View 6n6u on RCSB PDB site
Description: OXA-23 mutant F110A/M221A low pH form imipenem complex
Class: hydrolase
Keywords: carbapenemase, antibiotic resistance, mutant, HYDROLASE
Deposited on 2018-11-27, released 2018-12-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-02-13, with a file datestamp of 2019-02-08.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Beta-lactamase
  Species: ACINETOBACTER BAUMANNII [TaxId:470]
  Gene: ari-1, bla(OXA-23), bla-OXA-23, bla-oxa-23, bla_1, bla_2, bla_3, blaOXA, blaOXA-23, blaOXA23, OXA-23, oxa-23, oxa23, A7M90_19440, AB719_18095, ABUW_0563, AZE33_05050, AZE33_05100, AZE33_05150, AZE33_05250, C7G90_19950, CAS83_19595, CBE85_20255, CBI29_04474, CEJ63_03230, DV997_16620, DVA79_19285, IX87_16825, IX87_21860, LV38_03424, NG19_0098, SAMEA104305208_04008, SAMEA104305229_06308, SAMEA104305235_03908, SAMEA104305242_04084, SAMEA104305268_03570, SAMEA104305271_04290, SAMEA104305299_06196, SAMEA104305318_04148, SAMEA104305320_04271, SAMEA104305325_04185, SAMEA104305341_03854, SAMEA104305343_03919, SAMEA104305351_03822, SAMEA104305385_00775
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9L4P2 (1-242)
    • expression tag (0)
    • engineered mutation (190)
  Domains in SCOPe 2.08: d6n6ua1, d6n6ua2
• Heterogens: ID1, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >6n6uA (A:)
  aivqghnqvihqyfdekntsgvlviqtdkkinlygnalsranteyvpastfkmlnaligl
  enqktdineifkwkgekrsatawekdmtlgeamklsavpvyqelarrigldlmqkevkri
  gfgnaeigqqvdnfwlvgplkvtpiqevefvsqlahtqlpfsekvqanvknmllleesng
  ykifgktgwaadikpqvgwltgwveqpdgkivafalnmemrsempasirnellmkslkql
  nii
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6n6uA (A:)
  aivqghnqvihqyfdekntsgvlviqtdkkinlygnalsranteyvpastfkmlnaligl
  enqktdineifkkdmtlgeamklsavpvyqelarrigldlmqkevkrigfgnaeigqqvd
  nfwlvgplkvtpiqevefvsqlahtqlpfsekvqanvknmllleesngykifgktgwaad
  ikpqvgwltgwveqpdgkivafalnmemrsempasirnellmkslkqlnii