PDB entry 6n4y

View 6n4y on RCSB PDB site
Description: metabotropic glutamate receptor 5 extracellular domain with nb43
Deposited on 2018-11-20, released 2019-01-23
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.26 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Metabotropic glutamate receptor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: GRM5, GPRC1E, MGLUR5
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Metabotropic glutamate receptor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: GRM5, GPRC1E, MGLUR5
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Metabotropic glutamate receptor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: GRM5, GPRC1E, MGLUR5
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Metabotropic glutamate receptor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: GRM5, GPRC1E, MGLUR5
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Nanobody 43
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6N4Y (0-122)
  • Chain 'F':
    Compound: Nanobody 43
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6N4Y (0-122)
  • Chain 'G':
    Compound: Nanobody 43
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6N4Y (0-122)
  • Chain 'H':
    Compound: Nanobody 43
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6N4Y
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6n4yA (A:)
mllvnqshqgfnkehtskmvsaivlyvllaaaahsafqsserrvvahmpgdiiigalfsv
hhqptvdkvherkcgavreqygiqrveamlhtlerinsdptllpnitlgceirdscwhsa
valeqsiefirdslisseeeeglvrcvdgssssfrskkpivgvigpgsssvaiqvqnllq
lfnipqiaysatsmdlsdktlfkyfmrvvpsdaqqaramvdivkrynwtyvsavhtegny
gesgmeafkdmsakegiciahsykiysnageqsfdkllkkltshlpkarvvacfcegmtv
rgllmamrrlglageflllgsdgwadrydvtdgyqreavggitiklqspdvkwfddyylk
lrpetnhrnpwfqefwqhrfqcrlegfpqenskynktcnssltlkthhvqdskmgfvina
iysmayglhnmqmslcpgyaglcdamkpidgrklleslmktnftgvsgdtilfdengdsp
gryeimnfkemgkdyfdyinvgswdngelkmdddevwskksniirsvcsepcekgqikvi
rkgevsccwtctpckeneyvfdeytckacqlgswptddltgcdlipvqhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6n4yA (A:)
errvvahmpgdiiigalfsvhhqptvdkvherkcgavreqygiqrveamlhtlerinsdp
tllpnitlgceirdscwhsavaleqsiefirdsliskkpivgvigpgsssvaiqvqnllq
lfnipqiaysatsmdlsdktlfkyfmrvvpsdaqqaramvdivkrynwtyvsavhtegny
gesgmeafkdmsakegiciahsykiysnageqsfdkllkkltshlpkarvvacfcegmtv
rgllmamrrlglageflllgsdgwadrydvtdgyqreavggitiklqspdvkwfddyylk
lrpetnhrnpwfqefwqhrfqcrlegfpqenskynktcnssltlkthhvqdskmgfvina
iysmayglhnmqmslcpgyaglcdamkpidgrklleslmktnftgvsgdtilfdengdsp
gryeimnfkemgkdyfdyinvgswdngelkmdddeiirsvcsepcekkvirkgevsccwt
ctpckeneyvfdeytcqlgswptddlt

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6n4yB (B:)
mllvnqshqgfnkehtskmvsaivlyvllaaaahsafqsserrvvahmpgdiiigalfsv
hhqptvdkvherkcgavreqygiqrveamlhtlerinsdptllpnitlgceirdscwhsa
valeqsiefirdslisseeeeglvrcvdgssssfrskkpivgvigpgsssvaiqvqnllq
lfnipqiaysatsmdlsdktlfkyfmrvvpsdaqqaramvdivkrynwtyvsavhtegny
gesgmeafkdmsakegiciahsykiysnageqsfdkllkkltshlpkarvvacfcegmtv
rgllmamrrlglageflllgsdgwadrydvtdgyqreavggitiklqspdvkwfddyylk
lrpetnhrnpwfqefwqhrfqcrlegfpqenskynktcnssltlkthhvqdskmgfvina
iysmayglhnmqmslcpgyaglcdamkpidgrklleslmktnftgvsgdtilfdengdsp
gryeimnfkemgkdyfdyinvgswdngelkmdddevwskksniirsvcsepcekgqikvi
rkgevsccwtctpckeneyvfdeytckacqlgswptddltgcdlipvqhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6n4yB (B:)
errvvahmpgdiiigalfsvhhqptvdkvherkcgavreqygiqrveamlhtlerinsdp
tllpnitlgceirdscwhsavaleqsiefirdslikkpivgvigpgsssvaiqvqnllql
fnipqiaysatsmdlsdktlfkyfmrvvpsdaqqaramvdivkrynwtyvsavhtegnyg
esgmeafkdmsakegiciahsykiysnageqsfdkllkkltshlpkarvvacfcegmtvr
gllmamrrlglageflllgsdgwadrydvtdgyqreavggitiklqspdvkwfddyylkl
rpetnhrnpwfqefwqhrfqcrlegfpqenskynktcnssltlkthhvqdskmgfvinai
ysmayglhnmqmslcpgyaglcdamkpidgrklleslmktnftgvsgdtilfdengdspg
ryeimnfkemgkdyfdyinvgswdngelkmdddevwsksniirsvcsepcqikvirkgev
sccwtctpckeneyvfdeytckacqlgswptddltgc

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6n4yC (C:)
mllvnqshqgfnkehtskmvsaivlyvllaaaahsafqsserrvvahmpgdiiigalfsv
hhqptvdkvherkcgavreqygiqrveamlhtlerinsdptllpnitlgceirdscwhsa
valeqsiefirdslisseeeeglvrcvdgssssfrskkpivgvigpgsssvaiqvqnllq
lfnipqiaysatsmdlsdktlfkyfmrvvpsdaqqaramvdivkrynwtyvsavhtegny
gesgmeafkdmsakegiciahsykiysnageqsfdkllkkltshlpkarvvacfcegmtv
rgllmamrrlglageflllgsdgwadrydvtdgyqreavggitiklqspdvkwfddyylk
lrpetnhrnpwfqefwqhrfqcrlegfpqenskynktcnssltlkthhvqdskmgfvina
iysmayglhnmqmslcpgyaglcdamkpidgrklleslmktnftgvsgdtilfdengdsp
gryeimnfkemgkdyfdyinvgswdngelkmdddevwskksniirsvcsepcekgqikvi
rkgevsccwtctpckeneyvfdeytckacqlgswptddltgcdlipvqhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6n4yC (C:)
rvvahmpgdiiigalfsvhhqptvdkvherkcgavreqygiqrveamlhtlerinsdptl
lpnitlgceirdscwhsavaleqsiefirdslirskkpivgvigpgsssvaiqvqnllql
fnipqiaysatsmdlsdktlfkyfmrvvpsdaqqaramvdivkrynwtyvsavhtegnyg
esgmeafkdmsakegiciahsykiysnageqsfdkllkkltshlpkarvvacfcegmtvr
gllmamrrlglageflllgsdgwadrydvtdgyqreavggitiklqspdvkwfddyylkl
rpetnhrnpwfqefwqhrfqcrlegfpqenskynktcnssltlkthhvqdskmgfvinai
ysmayglhnmqmslcpgyaglcdamkpidgrklleslmktnftgvsgdtilfdengdspg
ryeimnfkemgkdyfdyinvgswdngelkmdddeirsvcsepcikvirkgevsccwtctp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6n4yD (D:)
mllvnqshqgfnkehtskmvsaivlyvllaaaahsafqsserrvvahmpgdiiigalfsv
hhqptvdkvherkcgavreqygiqrveamlhtlerinsdptllpnitlgceirdscwhsa
valeqsiefirdslisseeeeglvrcvdgssssfrskkpivgvigpgsssvaiqvqnllq
lfnipqiaysatsmdlsdktlfkyfmrvvpsdaqqaramvdivkrynwtyvsavhtegny
gesgmeafkdmsakegiciahsykiysnageqsfdkllkkltshlpkarvvacfcegmtv
rgllmamrrlglageflllgsdgwadrydvtdgyqreavggitiklqspdvkwfddyylk
lrpetnhrnpwfqefwqhrfqcrlegfpqenskynktcnssltlkthhvqdskmgfvina
iysmayglhnmqmslcpgyaglcdamkpidgrklleslmktnftgvsgdtilfdengdsp
gryeimnfkemgkdyfdyinvgswdngelkmdddevwskksniirsvcsepcekgqikvi
rkgevsccwtctpckeneyvfdeytckacqlgswptddltgcdlipvqhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6n4yD (D:)
rrvvahmpgdiiigalfsvhhqptvdkvherkcgavreqygiqrveamlhtlerinsdpt
llpnitlgceirdscwhsavaleqsiefirdsliskkpivgvigpgsssvaiqvqnllql
fnipqiaysatsmdlsdktlfkyfmrvvpsdaqqaramvdivkrynwtyvsavhtegnyg
esgmeafkdmsakegiciahsykiysnageqsfdkllkkltshlpkarvvacfcegmtvr
gllmamrrlglageflllgsdgwadrydvtdgyqreavggitiklqspdvkwfddyylkl
rpetnhrnpwfqefwqhrfqcrlegfpqenskynktcnssltlkthhvqdskmgfvinai
ysmayglhnmqmslcpgyaglcdamkpidgrklleslmktnftgvsgdtilfdengdspg
ryeimnfkemgkdyfdyinvgswdngelkmdddevwiirsvcsepcqikvirkgevsccw
tctpceneyvfdeytckacqgswptddltgc

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records:
    >6n4yE (E:)
qvqlvesggglvqaggslrlscaasgrtftsyamgwfrqapgkeresvaaisssggsthy
adsvkgrftisrdnskntvylqmnslkpedtavyycaaamygsrwpdweydywgqgtqvt
vss

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >6n4yF (F:)
qvqlvesggglvqaggslrlscaasgrtftsyamgwfrqapgkeresvaaisssggsthy
adsvkgrftisrdnskntvylqmnslkpedtavyycaaamygsrwpdweydywgqgtqvt
vss

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records:
    >6n4yG (G:)
qvqlvesggglvqaggslrlscaasgrtftsyamgwfrqapgkeresvaaisssggsthy
adsvkgrftisrdnskntvylqmnslkpedtavyycaaamygsrwpdweydywgqgtqvt
vss

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6n4yH (H:)
qvqlvesggglvqaggslrlscaasgrtftsyamgwfrqapgkeresvaaisssggsthy
adsvkgrftisrdnskntvylqmnslkpedtavyycaaamygsrwpdweydywgqgtqvt
vss

    Sequence, based on observed residues (ATOM records):
    >6n4yH (H:)
qlvesggglvqaggslrlscaasgrtftsyamgwfrqapgkeresvaaisssggsthyad
svkgrftisrdnskntvylqmnslkpedavyycaaamygsrwpdweydywgqgtqvtvs