PDB entry 6n46

View 6n46 on RCSB PDB site
Description: crystal structure of the cryptic polo box domain of a human activated plk4
Deposited on 2018-11-17, released 2019-09-04
The last revision was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 3.71 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase PLK4
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK4, SAK, STK18
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00444
      • conflict (138)
      • conflict (140)
      • conflict (144)
      • conflict (147)
  • Chain 'B':
    Compound: Serine/threonine-protein kinase PLK4
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK4, SAK, STK18
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00444
      • conflict (138)
      • conflict (140)
      • conflict (144)
      • conflict (147)
  • Chain 'C':
    Compound: Serine/threonine-protein kinase PLK4
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK4, SAK, STK18
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00444
      • conflict (138)
      • conflict (140)
      • conflict (144)
      • conflict (147)
  • Chain 'D':
    Compound: Serine/threonine-protein kinase PLK4
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK4, SAK, STK18
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00444
      • conflict (138)
      • conflict (140)
      • conflict (144)
      • conflict (147)
  • Chain 'E':
    Compound: Serine/threonine-protein kinase PLK4
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK4, SAK, STK18
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00444
      • conflict (138)
      • conflict (140)
      • conflict (144)
      • conflict (147)
  • Chain 'F':
    Compound: Serine/threonine-protein kinase PLK4
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK4, SAK, STK18
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00444
      • conflict (138)
      • conflict (140)
      • conflict (144)
      • conflict (147)
  • Chain 'G':
    Compound: Serine/threonine-protein kinase PLK4
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK4, SAK, STK18
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00444
      • conflict (138)
      • conflict (140)
      • conflict (144)
      • conflict (147)
  • Chain 'H':
    Compound: Serine/threonine-protein kinase PLK4
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK4, SAK, STK18
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00444
      • conflict (138)
      • conflict (140)
      • conflict (144)
      • conflict (147)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6n46A (A:)
mgsshhhhhhssglvprgshmgyqnrtlrsitsplvahrlkpirqktkkavvsildseev
cvelvkeyasqeyvkevlqissdgntitiyypnggrgfpladrppsptdnisrysfdnlp
ekywrkyqyasrfvqlvrekepkieyfdryakcilmenspgadfevwfydgvkihktedf
iqviektgksytlksesevnslkeeikmymdhaneghriclalesiiseeerktrsapff
piiigrkpg

    Sequence, based on observed residues (ATOM records):
    >6n46A (A:)
rsitsplvahrlkpirqktkkavvsildseevcvelvkeyasqeyvkevlqissdgntit
iyypndrppsptdnisrysfdnlpekywrkyqyasrfvqlvrekepkieyfdryakcilm
enspgadfevwfydgvkihktedfiqviektgksytlksesevnslkeeikmymdhaneg
hriclalesiiseeerktrsapffpiiigrkp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6n46B (B:)
mgsshhhhhhssglvprgshmgyqnrtlrsitsplvahrlkpirqktkkavvsildseev
cvelvkeyasqeyvkevlqissdgntitiyypnggrgfpladrppsptdnisrysfdnlp
ekywrkyqyasrfvqlvrekepkieyfdryakcilmenspgadfevwfydgvkihktedf
iqviektgksytlksesevnslkeeikmymdhaneghriclalesiiseeerktrsapff
piiigrkpg

    Sequence, based on observed residues (ATOM records):
    >6n46B (B:)
rsitsplvahrlkpirqktkkavvsildseevcvelvkeyasqeyvkevlqissdgntit
iyypndrppsptdnisrysfdnlpekywrkyqyasrfvqlvrekepkieyfdryakcilm
enspgadfevwfydgvkihktedfiqviektgksytlksesevnslkeeikmymdhaneg
hriclalesiiseeerktrsapffpiiigrkp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6n46C (C:)
mgsshhhhhhssglvprgshmgyqnrtlrsitsplvahrlkpirqktkkavvsildseev
cvelvkeyasqeyvkevlqissdgntitiyypnggrgfpladrppsptdnisrysfdnlp
ekywrkyqyasrfvqlvrekepkieyfdryakcilmenspgadfevwfydgvkihktedf
iqviektgksytlksesevnslkeeikmymdhaneghriclalesiiseeerktrsapff
piiigrkpg

    Sequence, based on observed residues (ATOM records):
    >6n46C (C:)
rsitsplvahrlkpirqktkkavvsildseevcvelvkeyasqeyvkevlqissdgntit
iyypndrppsptdnisrysfdnlpekywrkyqyasrfvqlvrekepkieyfdryakcilm
enspgadfevwfydgvkihktedfiqviektgksytlksesevnslkeeikmymdhaneg
hriclalesiiseeerktrsapffpiiigrkp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6n46D (D:)
mgsshhhhhhssglvprgshmgyqnrtlrsitsplvahrlkpirqktkkavvsildseev
cvelvkeyasqeyvkevlqissdgntitiyypnggrgfpladrppsptdnisrysfdnlp
ekywrkyqyasrfvqlvrekepkieyfdryakcilmenspgadfevwfydgvkihktedf
iqviektgksytlksesevnslkeeikmymdhaneghriclalesiiseeerktrsapff
piiigrkpg

    Sequence, based on observed residues (ATOM records):
    >6n46D (D:)
rsitsplvahrlkpirqktkkavvsildseevcvelvkeyasqeyvkevlqissdgntit
iyypndrppsptdnisrysfdnlpekywrkyqyasrfvqlvrekepkieyfdryakcilm
enspgadfevwfydgvkihktedfiqviektgksytlksesevnslkeeikmymdhaneg
hriclalesiiseeerktrsapffpiiigrkp

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6n46E (E:)
mgsshhhhhhssglvprgshmgyqnrtlrsitsplvahrlkpirqktkkavvsildseev
cvelvkeyasqeyvkevlqissdgntitiyypnggrgfpladrppsptdnisrysfdnlp
ekywrkyqyasrfvqlvrekepkieyfdryakcilmenspgadfevwfydgvkihktedf
iqviektgksytlksesevnslkeeikmymdhaneghriclalesiiseeerktrsapff
piiigrkpg

    Sequence, based on observed residues (ATOM records):
    >6n46E (E:)
rsitsplvahrlkpirqktkkavvsildseevcvelvkeyasqeyvkevlqissdgntit
iyypndrppsptdnisrysfdnlpekywrkyqyasrfvqlvrekepkieyfdryakcilm
enspgadfevwfydgvkihktedfiqviektgksytlksesevnslkeeikmymdhaneg
hriclalesiiseeerktrsapffpiiigrkp

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6n46F (F:)
mgsshhhhhhssglvprgshmgyqnrtlrsitsplvahrlkpirqktkkavvsildseev
cvelvkeyasqeyvkevlqissdgntitiyypnggrgfpladrppsptdnisrysfdnlp
ekywrkyqyasrfvqlvrekepkieyfdryakcilmenspgadfevwfydgvkihktedf
iqviektgksytlksesevnslkeeikmymdhaneghriclalesiiseeerktrsapff
piiigrkpg

    Sequence, based on observed residues (ATOM records):
    >6n46F (F:)
rsitsplvahrlkpirqktkkavvsildseevcvelvkeyasqeyvkevlqissdgntit
iyypndrppsptdnisrysfdnlpekywrkyqyasrfvqlvrekepkieyfdryakcilm
enspgadfevwfydgvkihktedfiqviektgksytlksesevnslkeeikmymdhaneg
hriclalesiiseeerktrsapffpiiigrkp

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6n46G (G:)
mgsshhhhhhssglvprgshmgyqnrtlrsitsplvahrlkpirqktkkavvsildseev
cvelvkeyasqeyvkevlqissdgntitiyypnggrgfpladrppsptdnisrysfdnlp
ekywrkyqyasrfvqlvrekepkieyfdryakcilmenspgadfevwfydgvkihktedf
iqviektgksytlksesevnslkeeikmymdhaneghriclalesiiseeerktrsapff
piiigrkpg

    Sequence, based on observed residues (ATOM records):
    >6n46G (G:)
rsitsplvahrlkpirqktkkavvsildseevcvelvkeyasqeyvkevlqissdgntit
iyypndrppsptdnisrysfdnlpekywrkyqyasrfvqlvrekepkieyfdryakcilm
enspgadfevwfydgvkihktedfiqviektgksytlksesevnslkeeikmymdhaneg
hriclalesiiseeerktrsapffpiiigrkp

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6n46H (H:)
mgsshhhhhhssglvprgshmgyqnrtlrsitsplvahrlkpirqktkkavvsildseev
cvelvkeyasqeyvkevlqissdgntitiyypnggrgfpladrppsptdnisrysfdnlp
ekywrkyqyasrfvqlvrekepkieyfdryakcilmenspgadfevwfydgvkihktedf
iqviektgksytlksesevnslkeeikmymdhaneghriclalesiiseeerktrsapff
piiigrkpg

    Sequence, based on observed residues (ATOM records):
    >6n46H (H:)
rsitsplvahrlkpirqktkkavvsildseevcvelvkeyasqeyvkevlqissdgntit
iyypndrppsptdnisrysfdnlpekywrkyqyasrfvqlvrekepkieyfdryakcilm
enspgadfevwfydgvkihktedfiqviektgksytlksesevnslkeeikmymdhaneg
hriclalesiiseeerktrsapffpiiigrkp