PDB entry 6n2w

View 6n2w on RCSB PDB site
Description: The structure of Stable-5-Lipoxygenase bound to NDGA
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Lipoxygenase, inhibitor, allostery, complex, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2018-11-14, released 2020-05-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-08, with a file datestamp of 2020-07-03.
Experiment type: XRAY
Resolution: 2.71 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Arachidonate 5-lipoxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALOX5, LOG5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09917 (Start-690)
      • expression tag (2-7)
      • conflict (33-34)
      • conflict (60-61)
      • conflict (92-93)
      • conflict (257)
      • conflict (578)
      • conflict (670-672)
  • Chain 'B':
    Compound: Arachidonate 5-lipoxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALOX5, LOG5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09917 (Start-690)
      • conflict (33-34)
      • conflict (61)
      • conflict (92-93)
      • conflict (257)
      • conflict (578)
      • conflict (670-672)
    Domains in SCOPe 2.08: d6n2wb1, d6n2wb2
  • Heterogens: 30Z, FE2, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6n2wB (B:)
    mgsshhhhhhssglvprgshmpsytvtvatgsqehagtddyiylslvgsagcsekhlldk
    gsfergavdsydvtvdeelgeiqlvriekrkygsnddwylkyitlktphgdyiefpcyrw
    itgdvevvlrdgraklarddqihilkqhrrkeletrqkqyrwmewnpgfplsidakchkd
    lprdiqfdsekgvdfvlnyskamenlfinrfmhmfqsswndfadfekifvkisntiserv
    mnhwqedlmfgyqflnganpvlirrctelpeklpvttemvecslerqlsleqevqqgnif
    ivdfelldgidanktdpctlqflaapicllyknlankivpiaiqlnqipgdenpiflpsd
    akydwllakiwvrssdfhvhqtithllrthlvsevfgiamyrqlpavhpifkllvahvrf
    tiaintkareqlicecglfdkanatgggghvqmvqramkdltyaslcfpeaikargmesk
    edipyyfyrddgllvweairtftaevvdiyyegdqvveedpelqdfvndvyvygmrgrks
    sgfpksvksreqlseyltvviftasaqhaavnfgqydwaswipnapptmrappptakgvv
    tieqivdtlpdrgrscwhlgavwalsqfqenelflgmypeehfiekpvkeamarfrknle
    aivsviaernenlqlpyyylspdripnsvai
    

    Sequence, based on observed residues (ATOM records): (download)
    >6n2wB (B:)
    psytvtvatgsqehagtddyiylslvgsagcsekhllsfergavdsydvtvdeelgeiql
    vriekrkygsnddwylkyitlktphgdyiefpcyrwitgdvevvlrdgraklarddqihi
    lkqhrrkeletrqkqyrwmewnpgfplsidakchkdlprdiqffvkisntiservmnhwq
    edlmfgyqflnganpvlirrctelpeklpvttemvecslerqlsleqevqqgnifivdfe
    lldgidflaapicllyknlankivpiaiqlnqipgdenpiflpsdakydwllakiwvrss
    dfhvhqtithllrthlvsevfgiamyrqlpavhpifkllvahvrftiaintkareqligg
    hvqmvqramkdltyaslcfpeaikargmeskedipyyfyrddgllvweairtftaevvdi
    yyegdqvveedpelqdfvndvyvygmrgrkssgfpksvksreqlseyltvviftasaqha
    avnfgqydwaswipnapptmrappptakgvvtieqivdtlpdrgrscwhlgavwalsqfq
    enelflgmypeehfiekpvkeamarfrknleaivsviaernenlqlpyyylspdripnsv
    ai