PDB entry 6n0p

View 6n0p on RCSB PDB site
Description: BRAF in complex with N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide (LXH254)
Class: transferase/transferase inhibitor
Keywords: Raf, bRaf, cRaf, CRAF kinase, Serine threonine protein, TRANSFERASE, transferase-transferase inhibitor complex
Deposited on 2018-11-07, released 2019-09-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-18, with a file datestamp of 2020-03-13.
Experiment type: XRAY
Resolution: 2.37 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6n0pa_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6n0pb_
  • Heterogens: K81, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6n0pA (A:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevirmq
dknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpka
mkrlmaeclkkkrderplfpqilasiellarsl

    Sequence, based on observed residues (ATOM records): (download) 
    >6n0pA (A:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatvksrwseqlsgsilwmapevirmqdknpy
sfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlm
aeclkkkrderplfpqilasiellarsl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6n0pB (B:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevirmq
dknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpka
mkrlmaeclkkkrderplfpqilasiellarsl

    Sequence, based on observed residues (ATOM records): (download) 
    >6n0pB (B:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglasgsilwmapevirmknpysfqsdvyafgiv
lyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrderp
lfpqilasiellarsl