PDB entry 6n0n

View 6n0n on RCSB PDB site
Description: Crystal structure of Tdp1 catalytic domain in complex with compound XZ574
Class: DNA BINDING PROTEIN, Hydrolase
Keywords: fragment based drug design, anti-cancer drug design, DNA BINDING PROTEIN, Hydrolase
Deposited on 2018-11-07, released 2019-11-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-13, with a file datestamp of 2019-11-08.
Experiment type: XRAY
Resolution: 1.48 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosyl-DNA phosphodiesterase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TDP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6n0na1, d6n0na2
  • Chain 'B':
    Compound: tyrosyl-DNA phosphodiesterase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TDP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6n0nb1, d6n0nb2
  • Heterogens: KAY, EDO, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6n0nA (A:)
sgegqdiwdmldkgnpfqfyltrvsgvkpkynsgalhikdilsplfgtlvssaqfnycfd
vdwlvkqyppefrkkpillvhgdkreakahlhaqakpyenislcqakldiafgthhtkmm
lllyeeglrvvihtsnlihadwhqktqgiwlsplypriadgthksgespthfkadlisyl
maynapslkewidvihkhdlsetnvyligstpgrfqgsqkdnwghfrlkkllkdhassmp
naeswpvvgqfssvgslgadeskwlcsefkesmltlgkesktpgkssvplyliypsvenv
rtslegypaggslpysiqtaekqnwlhsyfhkwsaetsgrsnamphiktymrpspdfski
awflvtsanlskaawgalekngtqlmirsyelgvlflpsafgldsfkvkqkffagsqepm
atfpvpydlppelygskdrpwiwnipyvkapdthgnmwvps

    Sequence, based on observed residues (ATOM records): (download) 
    >6n0nA (A:)
npfqfyltrvsgvkpkynsgalhikdilsplfgtlvssaqfnycfdvdwlvkqyppefrk
kpillvhgdkreakahlhaqakpyenislcqakldiafgthhtkmmlllyeeglrvviht
snlihadwhqktqgiwlsplypriadgthksgespthfkadlisylmaynapslkewidv
ihkhdlsetnvyligstpgrfqgsqkdnwghfrlkkllkdhassmpnaeswpvvgqfssv
gslgadeskwlcsefkesmltlgkesssvplyliypsvenvrtslegypaggslpysiqt
aekqnwlhsyfhkwsaetsgrsnamphiktymrpspdfskiawflvtsanlskaawgale
kngtqlmirsyelgvlflpsafgldsfkvkqkffapmatfpvpydlppelygskdrpwiw
nipyvkapdthgnmwvp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6n0nB (B:)
sgegqdiwdmldkgnpfqfyltrvsgvkpkynsgalhikdilsplfgtlvssaqfnycfd
vdwlvkqyppefrkkpillvhgdkreakahlhaqakpyenislcqakldiafgthhtkmm
lllyeeglrvvihtsnlihadwhqktqgiwlsplypriadgthksgespthfkadlisyl
maynapslkewidvihkhdlsetnvyligstpgrfqgsqkdnwghfrlkkllkdhassmp
naeswpvvgqfssvgslgadeskwlcsefkesmltlgkesktpgkssvplyliypsvenv
rtslegypaggslpysiqtaekqnwlhsyfhkwsaetsgrsnamphiktymrpspdfski
awflvtsanlskaawgalekngtqlmirsyelgvlflpsafgldsfkvkqkffagsqepm
atfpvpydlppelygskdrpwiwnipyvkapdthgnmwvps

    Sequence, based on observed residues (ATOM records): (download) 
    >6n0nB (B:)
npfqfyltrvsgvkpkynsgalhikdilsplfgtlvssaqfnycfdvdwlvkqyppefrk
kpillvhgdkreakahlhaqakpyenislcqakldiafgthhtkmmlllyeeglrvviht
snlihadwhqktqgiwlsplypriadgthksgespthfkadlisylmaynapslkewidv
ihkhdlsetnvyligstpgrfqgsqkdnwghfrlkkllkdhassmpnaeswpvvgqfssv
gslgadeskwlcsefkesmltlgkesssvplyliypsvenvrtslegypaggslpysiqt
aekqnwlhsyfhkwsaetsgrsnamphiktymrpspdfskiawflvtsanlskaawgale
kngtqlmirsyelgvlflpsafgldsfkvkqkffapmatfpvpydlppelygskdrpwiw
nipyvkapdthgnmwvp