PDB entry 6mxz

View 6mxz on RCSB PDB site
Description: Structure of 53BP1 Tudor domains in complex with small molecule UNC3474
Class: protein binding
Keywords: DNA damage response, Tudor domain, 53BP1, small molecule inhibitor, Protein binding
Deposited on 2018-10-31, released 2019-11-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-27, with a file datestamp of 2019-11-22.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxza1, d6mxza2
  • Chain 'B':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxzb1, d6mxzb2
  • Chain 'C':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxzc1, d6mxzc2
  • Chain 'D':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxzd1, d6mxzd2
  • Chain 'E':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12888 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.08: d6mxze1, d6mxze2, d6mxze3
  • Chain 'F':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxzf1, d6mxzf2
  • Chain 'G':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12888 (3-122)
      • expression tag (2)
    Domains in SCOPe 2.08: d6mxzg1, d6mxzg2, d6mxzg3
  • Chain 'H':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxzh1, d6mxzh2
  • Chain 'I':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxzi1, d6mxzi2
  • Chain 'J':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxzj1, d6mxzj2
  • Heterogens: K6S, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6mxzA (A:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxzA (A:)
sfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldtev
talsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqyglg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6mxzB (B:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxzB (B:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqyglg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6mxzC (C:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxzC (C:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqygl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6mxzD (D:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxzD (D:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqyglg

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6mxzE (E:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxzE (E:)
mnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldt
evtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqygl

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6mxzF (F:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxzF (F:)
sfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldtev
talsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqyglg

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6mxzG (G:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxzG (G:)
mnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldt
evtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqygl
g

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6mxzH (H:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxzH (H:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqygl

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6mxzI (I:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxzI (I:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqyglg

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6mxzJ (J:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxzJ (J:)
sfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldtev
talsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqygl