PDB entry 6mu7

View 6mu7 on RCSB PDB site
Description: Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-818251 in Complex with Human Antibodies 3H109L and 35O22 at 3.1 Angstrom
Class: immune system/inhibitor
Keywords: HIV-1 Envelope Prefusion Trimer, Entry Inhibitors, IMMUNE SYSTEM-INHIBITOR complex
Deposited on 2018-10-22, released 2019-01-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (93)
  • Chain 'D':
    Compound: 35O22 scFv heavy chain portion
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MU7 (0-End)
    Domains in SCOPe 2.08: d6mu7d_
  • Chain 'E':
    Compound: 35O22 scFv light chain portion
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MU7
    Domains in SCOPe 2.08: d6mu7e_
  • Chain 'G':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (106)
      • conflict (300)
      • conflict (468)
  • Chain 'H':
    Compound: 3H109L Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MU7 (0-End)
    Domains in SCOPe 2.08: d6mu7h1, d6mu7h2
  • Chain 'L':
    Compound: 3H109L Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MU7
    Domains in SCOPe 2.08: d6mu7l1, d6mu7l2
  • Heterogens: JYY, NAG, HOH

PDB Chain Sequences:

  • Chain 'B':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6mu7D (D:)
qgqlvqsgatttkpgssvkiscktsgyrfnfyhinwirqtagrgpewmgwispysgdknl
apafqdrvnmttdtevpvtsftstgaaymeirnltsddtgtyfcakgllrdgsstwlpyl
wgqgtlltvssast

    Sequence, based on observed residues (ATOM records): (download) 
    >6mu7D (D:)
qgqlvqsgatttkpgssvkiscktsgyrfnfyhinwirqtagrgpewmgwispysgdknl
apafqdrvnmttdtevpvtsftstgaaymeirnltsddtgtyfcakgllrdgsstwlpyl
wgqgtllt

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6mu7E (E:)
sqsvltqsasvsgslgqsvtisctgpnsvccshksiswyqwppgraptliiyednerapg
isprfsgyksywsayltisdlrpedettyyccsythnsgcvfgtgtkvsvlgqs

    Sequence, based on observed residues (ATOM records): (download) 
    >6mu7E (E:)
vltqsasvsgslgqsvtisctgpnsvccshksiswyqwppgraptliiyednerapgisp
rfsgyksywsayltisdlrpedettyyccsythnsgcvfgtgtkv

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6mu7H (H:)
qvqlqesgpglvkpsetlsltctvsggsisnyywswirqspgkglewigyisdsestnyn
pslksrviisvdtsknqlslklnsvtaadsaiyycaraqqgkriygmvsfgeffyyyymd
vwgkgttvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkgle
vlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6mu7H (H:)
qvqlqesgpglvkpsetlsltctvsggsisnyywswirqspgkglewigyisdsestnyn
pslksrviisvdtsknqlslklnsvtaadsaiyycaraqqgkriygmvsfgeffyyyymd
vwgkgttvtvssastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfp
avlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6mu7L (L:)
svtsyvrplsvalgetasiscgrqalgsravqwyqhrpgqapilliynnqdrpsgiperf
sgtpdinfgtratltisgveagdeadyychmwdsrsgfswsfggatrltvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpmqwkmhksyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6mu7L (L:)
syvrplsvalgetasiscgrqalgsravqwyqhrpgqapilliynnqdrpsgiperfsgt
pdinfgtratltisgveagdeadyychmwdsrsgfswsfggatrltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpmqwkmhksyscqvthegstvektvapt