PDB entry 6mso

View 6mso on RCSB PDB site
Description: crystal structure of mitochondrial fumarate hydratase from leishmania major in a complex with inhibitor thiomalate
Deposited on 2018-10-17, released 2019-01-30
The last revision was dated 2019-11-20, with a file datestamp of 2019-11-15.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fumarate hydratase
    Species: Leishmania major [TaxId:5664]
    Gene: LMJF_24_0320
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Fumarate hydratase
    Species: Leishmania major [TaxId:5664]
    Gene: LMJF_24_0320
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Fumarate hydratase
    Species: Leishmania major [TaxId:5664]
    Gene: LMJF_24_0320
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Fumarate hydratase
    Species: Leishmania major [TaxId:5664]
    Gene: LMJF_24_0320
    Database cross-references and differences (RAF-indexed):
  • Heterogens: JYD, SF4, GOL, 1PE, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6msoA (A:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefmlrrlapllaefnfvplvskvshk
etkyrlltkdyvsvvqpgaglpemlrvdpaaltllsstafddvehllrsshlmslrkifd
dpeasdndkfvalqllknanissarllpgcqdtgtaiiagyrgdqvfvpgndeealsrgv
ydifqkrnfrysqnvplsmydekntgtnlpaqidlyaskgmeysfmfvakgggsanksfl
lqetksvlnpkslrnflkeklamfgtsacppyhvavviggtsaemtmkvlkyaschyydd
litkpdmktgytfrdleleeevlkvcqnigmgaqfggkyyahdvrvirmprhgascpigi
gvscsadrqalgkinkdgvwleelemepsqylpdlkedellktpavmvnlnrpmpevlqe
lskhpvrtrlsltgtiivardsaharmremleagkplpqymkehpvyyagpakqpdglps
gsfgpttagrmdpfvdlfqshggsmvmlakgnrskqvtkachkyggfylgsiggpaavla
qnaikkvecldmkdlgmeavwrievenfpafivvddkgndffeql

    Sequence, based on observed residues (ATOM records):
    >6msoA (A:)
aefnfvplvskvshketkyrlltkdyvsvvqpgaglpemlrvdpaaltllsstafddveh
llrsshlmslrkifddpeasdndkfvalqllknanissarllpgcqdtgtaiiagyrgdq
vfvpgndeealsrgvydifqkrnfrysqnvplsmydekntgtnlpaqidlyaskgmeysf
mfvakgggsanksfllqetksvlnpkslrnflkeklamfgtsacppyhvavviggtsaem
tmkvlkyaschyyddlitkpdmktgytfrdleleeevlkvcqnigmgaqfggkyyahdvr
virmprhgascpigigvscsadrqalgkinkdgvwleelemepsqylpdlkedellktpa
vmvnlnrpmpevlqelskhpvrtrlsltgtiivardsaharmremleagkplpqymkehp
vyyagpakqpdglpsgsfgpttagrmdpfvdlfqshggsmvmlakgnrskqvtkachkyg
gfylgsiggpaavlaqnaikkvecldmkdlgmeavwrievenfpafivvddkgndffeql

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6msoB (B:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefmlrrlapllaefnfvplvskvshk
etkyrlltkdyvsvvqpgaglpemlrvdpaaltllsstafddvehllrsshlmslrkifd
dpeasdndkfvalqllknanissarllpgcqdtgtaiiagyrgdqvfvpgndeealsrgv
ydifqkrnfrysqnvplsmydekntgtnlpaqidlyaskgmeysfmfvakgggsanksfl
lqetksvlnpkslrnflkeklamfgtsacppyhvavviggtsaemtmkvlkyaschyydd
litkpdmktgytfrdleleeevlkvcqnigmgaqfggkyyahdvrvirmprhgascpigi
gvscsadrqalgkinkdgvwleelemepsqylpdlkedellktpavmvnlnrpmpevlqe
lskhpvrtrlsltgtiivardsaharmremleagkplpqymkehpvyyagpakqpdglps
gsfgpttagrmdpfvdlfqshggsmvmlakgnrskqvtkachkyggfylgsiggpaavla
qnaikkvecldmkdlgmeavwrievenfpafivvddkgndffeql

    Sequence, based on observed residues (ATOM records):
    >6msoB (B:)
aefnfvplvskvshketkyrlltkdyvsvvqpgaglpemlrvdpaaltllsstafddveh
llrsshlmslrkifddpeasdndkfvalqllknanissarllpgcqdtgtaiiagyrgdq
vfvpgndeealsrgvydifqkrnfrysqnvplsmydekntgtnlpaqidlyaskgmeysf
mfvakgggsanksfllqetksvlnpkslrnflkeklamfgtsacppyhvavviggtsaem
tmkvlkyaschyyddlitkpdmktgytfrdleleeevlkvcqnigmgaqfggkyyahdvr
virmprhgascpigigvscsadrqalgkinkdgvwleelemepsqylpdlkedellktpa
vmvnlnrpmpevlqelskhpvrtrlsltgtiivardsaharmremleagkplpqymkehp
vyyagpakqpdglpsgsfgpttagrmdpfvdlfqshggsmvmlakgnrskqvtkachkyg
gfylgsiggpaavlaqnaikkvecldmkdlgmeavwrievenfpafivvddkgndffeql

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6msoC (C:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefmlrrlapllaefnfvplvskvshk
etkyrlltkdyvsvvqpgaglpemlrvdpaaltllsstafddvehllrsshlmslrkifd
dpeasdndkfvalqllknanissarllpgcqdtgtaiiagyrgdqvfvpgndeealsrgv
ydifqkrnfrysqnvplsmydekntgtnlpaqidlyaskgmeysfmfvakgggsanksfl
lqetksvlnpkslrnflkeklamfgtsacppyhvavviggtsaemtmkvlkyaschyydd
litkpdmktgytfrdleleeevlkvcqnigmgaqfggkyyahdvrvirmprhgascpigi
gvscsadrqalgkinkdgvwleelemepsqylpdlkedellktpavmvnlnrpmpevlqe
lskhpvrtrlsltgtiivardsaharmremleagkplpqymkehpvyyagpakqpdglps
gsfgpttagrmdpfvdlfqshggsmvmlakgnrskqvtkachkyggfylgsiggpaavla
qnaikkvecldmkdlgmeavwrievenfpafivvddkgndffeql

    Sequence, based on observed residues (ATOM records):
    >6msoC (C:)
fnfvplvskvshketkyrlltkdyvsvvqpgaglpemlrvdpaaltllsstafddvehll
rsshlmslrkifddpeasdndkfvalqllknanissarllpgcqdtgtaiiagyrgdqvf
vpgndeealsrgvydifqkrnfrysqnvplsmydekntgtnlpaqidlyaskgmeysfmf
vakgggsanksfllqetksvlnpkslrnflkeklamfgtsacppyhvavviggtsaemtm
kvlkyaschyyddlitkpdmktgytfrdleleeevlkvcqnigmgaqfggkyyahdvrvi
rmprhgascpigigvscsadrqalgkinkdgvwleelemepsqylptpavmvnlnrpmpe
vlqelskhpvrtrlsltgtiivardsaharmremleagkplpqymkehpvyyagpakqpd
glpsgsfgpttagrmdpfvdlfqshggsmvmlakgnrskqvtkachkyggfylgsiggpa
avlaqnaikkvecldmkdlgmeavwrievenfpafivvddkgndffeq

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6msoD (D:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefmlrrlapllaefnfvplvskvshk
etkyrlltkdyvsvvqpgaglpemlrvdpaaltllsstafddvehllrsshlmslrkifd
dpeasdndkfvalqllknanissarllpgcqdtgtaiiagyrgdqvfvpgndeealsrgv
ydifqkrnfrysqnvplsmydekntgtnlpaqidlyaskgmeysfmfvakgggsanksfl
lqetksvlnpkslrnflkeklamfgtsacppyhvavviggtsaemtmkvlkyaschyydd
litkpdmktgytfrdleleeevlkvcqnigmgaqfggkyyahdvrvirmprhgascpigi
gvscsadrqalgkinkdgvwleelemepsqylpdlkedellktpavmvnlnrpmpevlqe
lskhpvrtrlsltgtiivardsaharmremleagkplpqymkehpvyyagpakqpdglps
gsfgpttagrmdpfvdlfqshggsmvmlakgnrskqvtkachkyggfylgsiggpaavla
qnaikkvecldmkdlgmeavwrievenfpafivvddkgndffeql

    Sequence, based on observed residues (ATOM records):
    >6msoD (D:)
fnfvplvskvshketkyrlltkdyvsvvqpgaglpemlrvdpaaltllsstafddvehll
rsshlmslrkifddpeasdndkfvalqllknanissarllpgcqdtgtaiiagyrgdqvf
vpgndeealsrgvydifqkrnfrysqnvplsmydekntgtnlpaqidlyaskgmeysfmf
vakgggsanksfllqetksvlnpkslrnflkeklamfgtsacppyhvavviggtsaemtm
kvlkyaschyyddlitkpdmktgytfrdleleeevlkvcqnigmgaqfggkyyahdvrvi
rmprhgascpigigvscsadrqalgkinkdgvwleelemepsqylpdlktpavmvnlnrp
mpevlqelskhpvrtrlsltgtiivardsaharmremleagkplpqymkehpvyyagpak
qpdglpsgsfgpttagrmdpfvdlfqshggsmvmlakgnrskqvtkachkyggfylgsig
gpaavlaqnaikkvecldmkdlgmeavwrievenfpafivvddkgndffeq