PDB entry 6mq6

View 6mq6 on RCSB PDB site
Description: Mapping the binding trajectory of a suicide inhibitor in human indoleamine 2,3-dioxygenase 1
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: indoleamine 2, 3-dioxygenase, heme-containing enzyme, BMS-986205, structure-based design, hIDO1-selective inhibitor, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex, OXYGEN BINDING
Deposited on 2018-10-09, released 2018-11-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-27, with a file datestamp of 2019-11-22.
Experiment type: XRAY
Resolution: 3.05 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mq6a_
  • Chain 'B':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mq6b_
  • Heterogens: H7P, HEM, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6mq6A (A:)
mskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhl
tdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcv
lanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqm
qerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvye
gfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsl
esnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqqpkenktsed
pskleakgtggtdlmnflktvrstteksllkegkgelnsklegkpipnpllgldstrtgh
hhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6mq6A (A:)
eyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhltdh
ksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcvlan
wkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmqer
dtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyegfw
edpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcslesn
psvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqtggtdlmnflktv
rstteksllke

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6mq6B (B:)
mskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhl
tdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcv
lanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqm
qerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvye
gfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsl
esnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqqpkenktsed
pskleakgtggtdlmnflktvrstteksllkegkgelnsklegkpipnpllgldstrtgh
hhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6mq6B (B:)
keyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhltd
hksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcvla
nwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmqe
rdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyegf
wedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsles
npsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipadlmnflktvrstte
ksllke