PDB entry 6mo9

View 6mo9 on RCSB PDB site
Description: N-terminal bromodomain of human BRD2 in complex with N-cyclopentyl-7-(3,5-dimethylisoxazol-4-yl)quinoline-5-sulfonamide inhibitor
Class: transcription/transcription inhibitor
Keywords: inhibitor, epigenetic reader, Bromo domain, transcription-transcription inhibitor complex
Deposited on 2018-10-04, released 2019-01-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-01-30, with a file datestamp of 2019-01-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mo9a_
  • Chain 'B':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mo9b_
  • Chain 'C':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mo9c_
  • Heterogens: JVY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6mo9A (A:)
smkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikr
rlennyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelv
vtipkn

    Sequence, based on observed residues (ATOM records): (download) 
    >6mo9A (A:)
rvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlenn
yywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqel

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6mo9B (B:)
smkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikr
rlennyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelv
vtipkn

    Sequence, based on observed residues (ATOM records): (download) 
    >6mo9B (B:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6mo9C (C:)
smkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikr
rlennyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelv
vtipkn

    Sequence, based on observed residues (ATOM records): (download) 
    >6mo9C (C:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmp