PDB entry 6mnc

View 6mnc on RCSB PDB site
Description: crystal structure of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with estrone
Class: oxidoreductase
Keywords: 17beta-hsd1, estrone, functional analyses, oxidoreductase
Deposited on 2018-10-01, released 2019-04-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-04-03, with a file datestamp of 2019-03-29.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estradiol 17-beta-dehydrogenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD17B1, E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6mnca_
  • Chain 'B':
    Compound: Estradiol 17-beta-dehydrogenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD17B1, E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6mncb_
  • Heterogens: J3Z, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6mncA (A:)
martvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsl
etlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtv
rmlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvh
lsliecgpvhtafmekvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaev
fltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgdvpakaeagaeagg
gagpgaedeagrgavgdpelgdppaapq

    Sequence, based on observed residues (ATOM records): (download) 
    >6mncA (A:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevfltalrapk
ptlryftterflpllrmrlddpsgsnyvtamhrevf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6mncB (B:)
martvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsl
etlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtv
rmlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvh
lsliecgpvhtafmekvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaev
fltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgdvpakaeagaeagg
gagpgaedeagrgavgdpelgdppaapq

    Sequence, based on observed residues (ATOM records): (download) 
    >6mncB (B:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevfltalrapk
ptlryftterflpllrmrlddpsgsnyvtamhrevf