PDB entry 6mmx

View 6mmx on RCSB PDB site
Description: triheteromeric nmda receptor glun1/glun2a/glun2a* in the 'extended' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at ph 7.4
Deposited on 2018-10-01, released 2018-11-28
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: EM
Resolution: 6.99 Å
R-factor: N/A
AEROSPACI score: 0.04 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutamate receptor ionotropic, NMDA 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Grin1, Nmdar1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Glutamate receptor ionotropic, NMDA 2A
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Grin2a
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00959 (Start-836)
      • engineered mutation (127)
      • engineered mutation (686)
      • conflict (757)
  • Chain 'C':
    Compound: Glutamate receptor ionotropic, NMDA 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Grin1, Nmdar1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Glutamate receptor ionotropic, NMDA 2A
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Grin2a
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00959 (Start-836)
      • engineered mutation (127)
      • engineered mutation (686)
      • conflict (757)
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6mmxA (A:)
mstmhlltfallfscsfaraacdpkivnigavlstrkheqmfreavnqankrhgswkiql
natsvthkpnaiqmalsvcedlissqvyailvshpptpndhftptpvsytagfyripvlg
lttrmsiysdksihlsflrtvppyshqssvwfemmrvynwnhiillvsddhegraaqkrl
etlleereskaekvlqfdpgtknvtallmearelearviilsaseddaatvyraaamlnm
tgsgyvwlvgereisgnalryapdgiiglqlingknesahisdavgvvaqavhelleken
itdpprgcvgntniwktgplfkrvlmsskyadgvtgrvefnedgdrkfanysimnlqnrk
lvqvgiyngthvipndrkiiwpggetekprgyqmstrlkivtihqepfvyvkptmsdgtc
keeftvngdpvkkvictgpndtspgsprhtvpqccygfcidlliklartmnftyevhlva
dgkfgtqervnnsnkkewngmmgellsgqadmivapltinneraqyiefskpfkyqglti
lvkkeiprstldsfmqpfqstlwllvglsvhvvavmlylldrfspfgrfkvnseeeeeda
ltlssamwfswgvllnsgigegaprsfsarilgmvwagfamiivasytanlaaflvldrp
eeritgindprlrnpsdkfiyatvkqssvdiyfrrqvelstmyrhmekhnyesaaeaiqa
vrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkdspwkqnvslsilksh
engfmedldktwvryqecdsrsnapatltfenmagvfmlvaggivagiflifieiayk

    Sequence, based on observed residues (ATOM records):
    >6mmxA (A:)
kivnigavlstrkheqmfreavnqankrhgswkiqlnatsvthkpnaiqmalsvcedlis
sqvyailvshpptpndhftptpvsytagfyripvlglttrmsiysdksihlsflrtvppy
shqssvwfemmrvynwnhiillvsddhegraaqkrletlleereskaekvlqfdpgtknv
tallmearelearviilsaseddaatvyraaamlnmtgsgyvwlvgereisgnalryapd
giiglqlingknesahisdavgvvaqavhellekenitdpprgcvgntniwktgplfkrv
lmsskyadgvtgrvefnedgdrkfanysimnlqnrklvqvgiyngthvipndrkiiwpgg
etekprgyqmstrlkivtihqepfvyvkptmsdgtckeeftvngdpvkkvictgpndtsp
gsprhtvpqccygfcidlliklartmnftyevhlvadgkfgtqervnnsnkkewngmmge
llsgqadmivapltinneraqyiefskpfkyqgltilvkkeipdsfmqpfqstlwllvgl
svhvvavmlylldrfspltlssamwfswgvllnsfsarilgmvwagfamiivasytanla
aflvldrpeeritgindprlrnpsdkfiyatvkqssvdiyfrrqvelstmyrhmekhnye
saaeaiqavrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkdspwkqnv
slsilkshengfmedldktwvryqetltfenmagvfmlvaggivagiflifieiayk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6mmxB (B:)
mgrlgywtllvlpallvwrdpaqnaaaekgppalniavllghshdvterelrnlwgpeqa
tglpldvnvvallmnrtdpkslithvcdlmsgarihglvfgddtdqeavaqmldfissqt
fipilgiaggasmimadkdptstffqfgasiqqqatvmlkimqdydwhvfslvttifpgy
rdfisfikttvdnsfvgwdmqnvitldtsfedaktqvqlkkihssvillycskdeavlil
searslgltgydffwivpslvsgntelipkefpsglisvsyddwdyslearvrdglgilt
taassmlekfsyipeakascygqaekpetplhtlhqfmvnvtwdgkdlsfteegyqvhpr
lvvivlnkdrewekvgkwenqtlslrhavwpryksfsdcepddnhlsivtleeapfvive
didpltetcvrntvpcrkfvkinnstnegmnvkkcckgfcidilkklsrtvkftydlylv
tngkhgkkvnnvwngmigevvyqravmavgsltineersevvdfsvpfvetgisvmvsrs
ngtvspsaflepfsasvwvmmfvmllivsaiavfvfeyfspvgynrnlakgkaphgpsft
igkaiwllwglvfnnsvpvqnpkgttskimvsvwaffaviflasytanlaafmiqeefvd
qvtglsdkkfqrphdysppfrfgtvpagsternirnnypymhqymtrfnqrgvedalvsl
ktgkldafiydaavlnykagrdegcklvtigsgyifattgygialqkgspwkrqidlall
qfvgdgemeeletlwltgichneknevmssqldidnmagvfymlaaamalslitfiw

    Sequence, based on observed residues (ATOM records):
    >6mmxB (B:)
lniavllghshdvterelrnlwgpeqatglpldvnvvallmnrtdpkslithvcdlmsga
rihglvfgddtdqeavaqmldfissqtfipilgiaggasmimadkdptstffqfgasiqq
qatvmlkimqdydwhvfslvttifpgyrdfisfikttvdnsfvgwdmqnvitldtsfeda
ktqvqlkkihssvillycskdeavlilsearslgltgydffwivpslvsgntelipkefp
sglisvsyddwdyslearvrdglgilttaassmlekfsyipeakascygqplhtlhqfmv
nvtwdgkdlsfteegyqvhprlvvivlnkdrewekvgkwenqtlslrhavwpryksfsdc
epddnhlsivtleeapfvivedidpltetcvrntvpcrkfvkinnstnegmnvkkcckgf
cidilkklsrtvkftydlylvtngkhgkkvnnvwngmigevvyqravmavgsltineers
evvdfsvpfvetgisvmvsrsvspsaflepfsasvwvmmfvmllivsaiavfvfeyfsft
igkaiwllwglvfnnsvpvqnpkgttskimvsvwaffaviflasytanlaafmiqeefvd
qvtglsdkkfqrphdysppfrfgtvpagsternirnnypymhqymtrfnqrgvedalvsl
ktgkldafiydaavlnykagrdegcklvtigsgyifattgygialqkgspwkrqidlall
qfvgdgemeeletlwltgichnssqldidnmagvfymlaaamalslitfiw

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6mmxC (C:)
mstmhlltfallfscsfaraacdpkivnigavlstrkheqmfreavnqankrhgswkiql
natsvthkpnaiqmalsvcedlissqvyailvshpptpndhftptpvsytagfyripvlg
lttrmsiysdksihlsflrtvppyshqssvwfemmrvynwnhiillvsddhegraaqkrl
etlleereskaekvlqfdpgtknvtallmearelearviilsaseddaatvyraaamlnm
tgsgyvwlvgereisgnalryapdgiiglqlingknesahisdavgvvaqavhelleken
itdpprgcvgntniwktgplfkrvlmsskyadgvtgrvefnedgdrkfanysimnlqnrk
lvqvgiyngthvipndrkiiwpggetekprgyqmstrlkivtihqepfvyvkptmsdgtc
keeftvngdpvkkvictgpndtspgsprhtvpqccygfcidlliklartmnftyevhlva
dgkfgtqervnnsnkkewngmmgellsgqadmivapltinneraqyiefskpfkyqglti
lvkkeiprstldsfmqpfqstlwllvglsvhvvavmlylldrfspfgrfkvnseeeeeda
ltlssamwfswgvllnsgigegaprsfsarilgmvwagfamiivasytanlaaflvldrp
eeritgindprlrnpsdkfiyatvkqssvdiyfrrqvelstmyrhmekhnyesaaeaiqa
vrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkdspwkqnvslsilksh
engfmedldktwvryqecdsrsnapatltfenmagvfmlvaggivagiflifieiayk

    Sequence, based on observed residues (ATOM records):
    >6mmxC (C:)
kivnigavlstrkheqmfreavnqankrhgswkiqlnatsvthkpnaiqmalsvcedlis
sqvyailvshpptpndhftptpvsytagfyripvlglttrmsiysdksihlsflrtvppy
shqssvwfemmrvynwnhiillvsddhegraaqkrletlleereskaekvlqfdpgtknv
tallmearelearviilsaseddaatvyraaamlnmtgsgyvwlvgereisgnalryapd
giiglqlingknesahisdavgvvaqavhellekenitdpprgcvgntniwktgplfkrv
lmsskyadgvtgrvefnedgdrkfanysimnlqnrklvqvgiyngthvipndrkiiwpgg
etekprgyqmstrlkivtihqepfvyvkptmsdgtckeeftvngdpvkkvictgpndtsp
gsprhtvpqccygfcidlliklartmnftyevhlvadgkfgtqervnnsnkkewngmmge
llsgqadmivapltinneraqyiefskpfkyqgltilvkkeiprldsfmqpfqstlwllv
glsvhvvavmlylldrfspltlssamwfswgvllnsaprsfsarilgmvwagfamiivas
ytanlaaflvldrpeeritgindprlrnpsdkfiyatvkqssvdiyfrrqvelstmyrhm
ekhnyesaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkds
pwkqnvslsilkshengfmedldktwvryqetltfenmagvfmlvaggivagiflifiei
ayk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6mmxD (D:)
mgrlgywtllvlpallvwrdpaqnaaaekgppalniavllghshdvterelrnlwgpeqa
tglpldvnvvallmnrtdpkslithvcdlmsgarihglvfgddtdqeavaqmldfissqt
fipilgiaggasmimadkdptstffqfgasiqqqatvmlkimqdydwhvfslvttifpgy
rdfisfikttvdnsfvgwdmqnvitldtsfedaktqvqlkkihssvillycskdeavlil
searslgltgydffwivpslvsgntelipkefpsglisvsyddwdyslearvrdglgilt
taassmlekfsyipeakascygqaekpetplhtlhqfmvnvtwdgkdlsfteegyqvhpr
lvvivlnkdrewekvgkwenqtlslrhavwpryksfsdcepddnhlsivtleeapfvive
didpltetcvrntvpcrkfvkinnstnegmnvkkcckgfcidilkklsrtvkftydlylv
tngkhgkkvnnvwngmigevvyqravmavgsltineersevvdfsvpfvetgisvmvsrs
ngtvspsaflepfsasvwvmmfvmllivsaiavfvfeyfspvgynrnlakgkaphgpsft
igkaiwllwglvfnnsvpvqnpkgttskimvsvwaffaviflasytanlaafmiqeefvd
qvtglsdkkfqrphdysppfrfgtvpagsternirnnypymhqymtrfnqrgvedalvsl
ktgkldafiydaavlnykagrdegcklvtigsgyifattgygialqkgspwkrqidlall
qfvgdgemeeletlwltgichneknevmssqldidnmagvfymlaaamalslitfiw

    Sequence, based on observed residues (ATOM records):
    >6mmxD (D:)
lniavllghshdvterelrnlwgpeqatglpldvnvvallmnrtdpkslithvcdlmsga
rihglvfgddtdqeavaqmldfissqtfipilgiaggasmimadkdptstffqfgasiqq
qatvmlkimqdydwhvfslvttifpgyrdfisfikttvdnsfvgwdmqnvitldtsfeda
ktqvqlkkihssvillycskdeavlilsearslgltgydffwivpslvsgntelipkefp
sglisvsyddwdyslearvrdglgilttaassmlekfsyipeakascygqplhtlhqfmv
nvtwdgkdlsfteegyqvhprlvvivlnkdrewekvgkwenqtlslrhavwprykdnhls
ivtleeapfvivedidpltetcvrntvpcrkfvkinnstnegmnvkkcckgfcidilkkl
srtvkftydlylvtngkhgkkvnnvwngmigevvyqravmavgsltineersevvdfsvp
fvetgisvmvsrsngtvspsaflepfsasvwvmmfvmllivsaiavfvfeyfsftigkai
wllwglvfnnsvpvqnpkgttskimvsvwaffaviflasytanlaafmiqeefvdqvtgl
sdkkfqrphdysppfrfgtvpagsternirnnypymhqymtrfnqrgvedalvslktgkl
dafiydaavlnykagrdegcklvtigsgyifattgygialqkgspwkrqidlallqfvgd
gemeeletlwltgichnidnmagvfymlaaamalslitfiw