PDB entry 6mhs

View 6mhs on RCSB PDB site
Description: structure of the human trpv3 channel in a putative sensitized conformation
Deposited on 2018-09-18, released 2018-10-03
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: EM
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transient receptor potential cation channel subfamily V member 3
    Species: Homo sapiens [TaxId:9606]
    Gene: Trpv3
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Transient receptor potential cation channel subfamily V member 3
    Species: Homo sapiens [TaxId:9606]
    Gene: Trpv3
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Transient receptor potential cation channel subfamily V member 3
    Species: Homo sapiens [TaxId:9606]
    Gene: Trpv3
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Transient receptor potential cation channel subfamily V member 3
    Species: Homo sapiens [TaxId:9606]
    Gene: Trpv3
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6mhsA (A:)
mekahpkemvplmgkrvaapsgnpailpekrpaeitptkksahffleiegfepnptvakt
sppvfskpmdsnirqcisgncddmdspqspqddvtetpsnpnspsaqlakeeqrrkkrrl
kkrifaavsegcveelvellvelqelcrrrhdedvpdflmhkltasdtgktclmkallni
npntkeivrillafaeendilgrfinaeyteeayegqtalniaierrqgdiaalliaaga
dvnahakgaffnpkyqhegfyfgetplalaactnqpeivqllmeheqtditsrdsrgnni
lhalvtvaedfktqndfvkrmydmillrsgnwelettrnndgltplqlaakmgkaeilky
ilsreikekrlrslsrkftdwaygpvssslydltnvdtttdnsvleitvyntnidnrhem
ltleplhtllhmkwkkfakhmfflsfcfyffynitltlvsyyrpreeeaiphplalthkm
gwlqllgrmfvliwamcisvkegiaifllrpsdlqsilsdawfhfvffiqavlvilsvfl
ylfaykeylaclvlamalgwanmlyytrgfqsmgmysvmiqkvilhdvlkflfvyivfll
gfgvalasliekcpkdnkdcssygsfsdavlelfkltiglgdlniqqnskypilflflli
tyviltfvlllnmlialmgetvenvskeseriwrlqrartilefekmlpewlrsrfrmge
lckvaeddfrlclrinevkwtewkthvsflnedpgpvrrtdfnkiqdssrnnskttlnaf
eeveefpetsvvdaglevlfqgpaaavdykddddkahhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6mhsA (A:)
rlkkrifaavsegcveelvellvelqelcrrrvpdflmhkltasdtgktclmkallninp
ntkeivrillafaeendilgrfinaeyteeayegqtalniaierrqgdiaalliaagadv
nahakgaffnpkyqhegfyfgetplalaactnqpeivqllmeheqtditsrdsrgnnilh
alvtvaedfktqndfvkrmydmillrsgnwelettrnndgltplqlaakmgkaeilkyil
sreikekrlrslsrkftdwaygpvssslydltnvdtttdnsvleitvyntnidnrhemlt
leplhtllhmkwkkfakhmfflsfcfyffynitltlvsyyrgwlqllgrmfvliwamcis
vkegiaifllsdawfhfvffiqavlvilsvflylfaykeylaclvlamalgwanmlyytr
gfqsmgmysvmiqkvilhdvlkflfvyivfllgfgvalasliekcpkdnkdcssygsfsd
avlelfkltiglgdlniqqnskypilflfllityviltfvlllnmlialmgetvenvske
seriwrlqrartilefekmlpewlrsrfrmgelckvaeddfrlclrinevkwtewkthvs
flnedpg

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6mhsB (B:)
mekahpkemvplmgkrvaapsgnpailpekrpaeitptkksahffleiegfepnptvakt
sppvfskpmdsnirqcisgncddmdspqspqddvtetpsnpnspsaqlakeeqrrkkrrl
kkrifaavsegcveelvellvelqelcrrrhdedvpdflmhkltasdtgktclmkallni
npntkeivrillafaeendilgrfinaeyteeayegqtalniaierrqgdiaalliaaga
dvnahakgaffnpkyqhegfyfgetplalaactnqpeivqllmeheqtditsrdsrgnni
lhalvtvaedfktqndfvkrmydmillrsgnwelettrnndgltplqlaakmgkaeilky
ilsreikekrlrslsrkftdwaygpvssslydltnvdtttdnsvleitvyntnidnrhem
ltleplhtllhmkwkkfakhmfflsfcfyffynitltlvsyyrpreeeaiphplalthkm
gwlqllgrmfvliwamcisvkegiaifllrpsdlqsilsdawfhfvffiqavlvilsvfl
ylfaykeylaclvlamalgwanmlyytrgfqsmgmysvmiqkvilhdvlkflfvyivfll
gfgvalasliekcpkdnkdcssygsfsdavlelfkltiglgdlniqqnskypilflflli
tyviltfvlllnmlialmgetvenvskeseriwrlqrartilefekmlpewlrsrfrmge
lckvaeddfrlclrinevkwtewkthvsflnedpgpvrrtdfnkiqdssrnnskttlnaf
eeveefpetsvvdaglevlfqgpaaavdykddddkahhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6mhsB (B:)
rlkkrifaavsegcveelvellvelqelcrrrvpdflmhkltasdtgktclmkallninp
ntkeivrillafaeendilgrfinaeyteeayegqtalniaierrqgdiaalliaagadv
nahakgaffnpkyqhegfyfgetplalaactnqpeivqllmeheqtditsrdsrgnnilh
alvtvaedfktqndfvkrmydmillrsgnwelettrnndgltplqlaakmgkaeilkyil
sreikekrlrslsrkftdwaygpvssslydltnvdtttdnsvleitvyntnidnrhemlt
leplhtllhmkwkkfakhmfflsfcfyffynitltlvsyyrgwlqllgrmfvliwamcis
vkegiaifllsdawfhfvffiqavlvilsvflylfaykeylaclvlamalgwanmlyytr
gfqsmgmysvmiqkvilhdvlkflfvyivfllgfgvalasliekcpkdnkdcssygsfsd
avlelfkltiglgdlniqqnskypilflfllityviltfvlllnmlialmgetvenvske
seriwrlqrartilefekmlpewlrsrfrmgelckvaeddfrlclrinevkwtewkthvs
flnedpg

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6mhsC (C:)
mekahpkemvplmgkrvaapsgnpailpekrpaeitptkksahffleiegfepnptvakt
sppvfskpmdsnirqcisgncddmdspqspqddvtetpsnpnspsaqlakeeqrrkkrrl
kkrifaavsegcveelvellvelqelcrrrhdedvpdflmhkltasdtgktclmkallni
npntkeivrillafaeendilgrfinaeyteeayegqtalniaierrqgdiaalliaaga
dvnahakgaffnpkyqhegfyfgetplalaactnqpeivqllmeheqtditsrdsrgnni
lhalvtvaedfktqndfvkrmydmillrsgnwelettrnndgltplqlaakmgkaeilky
ilsreikekrlrslsrkftdwaygpvssslydltnvdtttdnsvleitvyntnidnrhem
ltleplhtllhmkwkkfakhmfflsfcfyffynitltlvsyyrpreeeaiphplalthkm
gwlqllgrmfvliwamcisvkegiaifllrpsdlqsilsdawfhfvffiqavlvilsvfl
ylfaykeylaclvlamalgwanmlyytrgfqsmgmysvmiqkvilhdvlkflfvyivfll
gfgvalasliekcpkdnkdcssygsfsdavlelfkltiglgdlniqqnskypilflflli
tyviltfvlllnmlialmgetvenvskeseriwrlqrartilefekmlpewlrsrfrmge
lckvaeddfrlclrinevkwtewkthvsflnedpgpvrrtdfnkiqdssrnnskttlnaf
eeveefpetsvvdaglevlfqgpaaavdykddddkahhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6mhsC (C:)
rlkkrifaavsegcveelvellvelqelcrrrvpdflmhkltasdtgktclmkallninp
ntkeivrillafaeendilgrfinaeyteeayegqtalniaierrqgdiaalliaagadv
nahakgaffnpkyqhegfyfgetplalaactnqpeivqllmeheqtditsrdsrgnnilh
alvtvaedfktqndfvkrmydmillrsgnwelettrnndgltplqlaakmgkaeilkyil
sreikekrlrslsrkftdwaygpvssslydltnvdtttdnsvleitvyntnidnrhemlt
leplhtllhmkwkkfakhmfflsfcfyffynitltlvsyyrgwlqllgrmfvliwamcis
vkegiaifllsdawfhfvffiqavlvilsvflylfaykeylaclvlamalgwanmlyytr
gfqsmgmysvmiqkvilhdvlkflfvyivfllgfgvalasliekcpkdnkdcssygsfsd
avlelfkltiglgdlniqqnskypilflfllityviltfvlllnmlialmgetvenvske
seriwrlqrartilefekmlpewlrsrfrmgelckvaeddfrlclrinevkwtewkthvs
flnedpg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6mhsD (D:)
mekahpkemvplmgkrvaapsgnpailpekrpaeitptkksahffleiegfepnptvakt
sppvfskpmdsnirqcisgncddmdspqspqddvtetpsnpnspsaqlakeeqrrkkrrl
kkrifaavsegcveelvellvelqelcrrrhdedvpdflmhkltasdtgktclmkallni
npntkeivrillafaeendilgrfinaeyteeayegqtalniaierrqgdiaalliaaga
dvnahakgaffnpkyqhegfyfgetplalaactnqpeivqllmeheqtditsrdsrgnni
lhalvtvaedfktqndfvkrmydmillrsgnwelettrnndgltplqlaakmgkaeilky
ilsreikekrlrslsrkftdwaygpvssslydltnvdtttdnsvleitvyntnidnrhem
ltleplhtllhmkwkkfakhmfflsfcfyffynitltlvsyyrpreeeaiphplalthkm
gwlqllgrmfvliwamcisvkegiaifllrpsdlqsilsdawfhfvffiqavlvilsvfl
ylfaykeylaclvlamalgwanmlyytrgfqsmgmysvmiqkvilhdvlkflfvyivfll
gfgvalasliekcpkdnkdcssygsfsdavlelfkltiglgdlniqqnskypilflflli
tyviltfvlllnmlialmgetvenvskeseriwrlqrartilefekmlpewlrsrfrmge
lckvaeddfrlclrinevkwtewkthvsflnedpgpvrrtdfnkiqdssrnnskttlnaf
eeveefpetsvvdaglevlfqgpaaavdykddddkahhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6mhsD (D:)
rlkkrifaavsegcveelvellvelqelcrrrvpdflmhkltasdtgktclmkallninp
ntkeivrillafaeendilgrfinaeyteeayegqtalniaierrqgdiaalliaagadv
nahakgaffnpkyqhegfyfgetplalaactnqpeivqllmeheqtditsrdsrgnnilh
alvtvaedfktqndfvkrmydmillrsgnwelettrnndgltplqlaakmgkaeilkyil
sreikekrlrslsrkftdwaygpvssslydltnvdtttdnsvleitvyntnidnrhemlt
leplhtllhmkwkkfakhmfflsfcfyffynitltlvsyyrgwlqllgrmfvliwamcis
vkegiaifllsdawfhfvffiqavlvilsvflylfaykeylaclvlamalgwanmlyytr
gfqsmgmysvmiqkvilhdvlkflfvyivfllgfgvalasliekcpkdnkdcssygsfsd
avlelfkltiglgdlniqqnskypilflfllityviltfvlllnmlialmgetvenvske
seriwrlqrartilefekmlpewlrsrfrmgelckvaeddfrlclrinevkwtewkthvs
flnedpg