PDB entry 6mfr

View 6mfr on RCSB PDB site
Description: human argonaute2-mir-122 bound to a target rna with three central mismatches (bu3)
Deposited on 2018-09-12, released 2019-08-07
The last revision was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 3.6 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein argonaute-2
    Species: Homo sapiens [TaxId:9606]
    Gene: AGO2, EIF2C2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UKV8 (Start-858)
      • engineered mutation (386)
      • engineered mutation (668)
  • Chain 'B':
    Compound: Protein argonaute-2
    Species: Homo sapiens [TaxId:9606]
    Gene: AGO2, EIF2C2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UKV8 (Start-858)
      • engineered mutation (386)
      • engineered mutation (668)
  • Chain 'C':
    Compound: RNA (5'-r(p*up*gp*gp*ap*gp*up*gp*up*gp*ap*cp*ap*ap*up*gp*gp*up*gp*up*u)-3')
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'D':
    Compound: RNA (5'-r(p*up*gp*gp*ap*gp*up*gp*up*gp*ap*cp*ap*ap*up*gp*gp*up*gp*up*u)-3')
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'E':
    Compound: RNA (5'-r(p*ap*ap*ap*cp*ap*cp*cp*ap*up*up*up*up*cp*ap*cp*ap*cp*up*cp*cp*ap*ap*a)-3')
    Species: UNIDENTIFIED, synthetic [TaxId:32644]
  • Chain 'F':
    Compound: RNA (5'-r(p*ap*ap*ap*cp*ap*cp*cp*ap*up*up*up*up*cp*ap*cp*ap*cp*up*cp*cp*ap*ap*a)-3')
    Species: UNIDENTIFIED, synthetic [TaxId:32644]
  • Heterogens: IPH, PO4

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6mfrA (A:)
mysgagpalappappppiqgyafkppprpdfgtsgrtiklqanffemdipkidiyhyeld
ikpekcprrvnreivehmvqhfktqifgdrkpvfdgrknlytamplpigrdkvelevtlp
gegkdrifkvsikwvscvslqalhdalsgrlpsvpfetiqaldvvmrhlpsmrytpvgrs
fftasegcsnplgggrevwfgfhqsvrpslwkmmlnidvsatafykaqpviefvcevldf
ksieeqqkpltdsqrvkftkeikglkveithcgqmkrkyrvcnvtrrpashqtfplqqes
gqtvectvaqyfkdrhklvlryphlpclqvgqeqkhtylplevcnivagqrcikkltdnq
tstmiratarsapdrqeeisklmrsadfntdpyvrefgimvkdemtdvtgrvlqppsily
ggrnkaiatpvqgvwdmrnkqfhtgieikvwaiacfapqrqctevhlksfteqlrkisrd
agmpiqgqpcfckyaqgadsvepmfrhlkntyaglqlvvvilpgktpvyaevkrvgdtvl
gmatqcvqmknvqrttpqtlsnlclkinvklggvnnillpqgrppvfqqpviflgadvth
ppagdgkkpsiaavvgsmdahpnrycatvrvqqhrqeiiqdlaamvrelliqfykstrfk
ptriifyragvsegqfqqvlhhellaireaciklekdyqpgitfivvqkrhhtrlfctdk
nervgksgnipagttvdtkithptefdfylcshagiqgtsrpshyhvlwddnrfssdelq
iltyqlchtyvrctrsvsipapayyahlvafraryhlvdkehdaaegdhtdgqangrdhq
alakavqvhqdtlrtmyfa

    Sequence, based on observed residues (ATOM records):
    >6mfrA (A:)
afkppprpdfgtsgrtiklqanffemdipkidiyhyeldikpekcprrvnreivehmvqh
fktqifgkpvfdgrknlytamplpigrdkvelevtlpifkvsikwvscvslqalhdalsg
rlpsvpfetiqaldvvmrhlpsmrytpvgrsfftasegcsnplgggrevwfgfhqsvrps
lwkmmlnidvsatafykaqpviefvcevldfksieeqqkpltdsqrvkftkeikglkvei
thckrkyrvcnvtrrpashqtfplqqesgqtvectvaqyfkdrhklvlryphlpclqvgq
eqkhtylplevcnivagqrcikkltdnqtstmiratarsapdrqeeisklmrsadfntdp
yvrefgimvkdemtdvtgrvlqppsilyggrnkaiatpvqgvwdmrnkqfhtgieikvwa
iacfapqrqctevhlksfteqlrkisrdagmpiqgqpcfckyaqgadsvepmfrhlknty
aglqlvvvilpgktpvyaevkrvgdtvlgmatqcvqmknvqrttpqtlsnlclkinvklg
gvnnillpqgrppvfqqpviflgadvthppkkpsiaavvgsmdahpnrycatvrvqqhrq
eiiqdlaamvrelliqfykstrfkptriifyragvsegqfqqvlhhellaireaciklek
dyqpgitfivvqkrhhtrlfctdknervgksgnipagttvdtkithptefdfylcshagi
qgtsrpshyhvlwddnrfssdelqiltyqlchtyvrctrsvsipapayyahlvafraryh
dhqalakavqvhqdtlrtmyfa

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6mfrB (B:)
mysgagpalappappppiqgyafkppprpdfgtsgrtiklqanffemdipkidiyhyeld
ikpekcprrvnreivehmvqhfktqifgdrkpvfdgrknlytamplpigrdkvelevtlp
gegkdrifkvsikwvscvslqalhdalsgrlpsvpfetiqaldvvmrhlpsmrytpvgrs
fftasegcsnplgggrevwfgfhqsvrpslwkmmlnidvsatafykaqpviefvcevldf
ksieeqqkpltdsqrvkftkeikglkveithcgqmkrkyrvcnvtrrpashqtfplqqes
gqtvectvaqyfkdrhklvlryphlpclqvgqeqkhtylplevcnivagqrcikkltdnq
tstmiratarsapdrqeeisklmrsadfntdpyvrefgimvkdemtdvtgrvlqppsily
ggrnkaiatpvqgvwdmrnkqfhtgieikvwaiacfapqrqctevhlksfteqlrkisrd
agmpiqgqpcfckyaqgadsvepmfrhlkntyaglqlvvvilpgktpvyaevkrvgdtvl
gmatqcvqmknvqrttpqtlsnlclkinvklggvnnillpqgrppvfqqpviflgadvth
ppagdgkkpsiaavvgsmdahpnrycatvrvqqhrqeiiqdlaamvrelliqfykstrfk
ptriifyragvsegqfqqvlhhellaireaciklekdyqpgitfivvqkrhhtrlfctdk
nervgksgnipagttvdtkithptefdfylcshagiqgtsrpshyhvlwddnrfssdelq
iltyqlchtyvrctrsvsipapayyahlvafraryhlvdkehdaaegdhtdgqangrdhq
alakavqvhqdtlrtmyfa

    Sequence, based on observed residues (ATOM records):
    >6mfrB (B:)
afkppprpdfgtsgrtiklqanffemdipkidiyhyeldikpcprrvnreivehmvqhfk
tqifgkpvfdgrknlytamplpigrdkvelevtlpifkvsikwvscvslqalhdalsgrl
psvpfetiqaldvvmrhlpsmrytpvgrsfftasegcsnplgggrevwfgfhqsvrpslw
kmmlnidvsatafykaqpviefvcevldfksieeqqkpltdsqrvkftkeikglkveikr
kyrvcnvtrrpashqtfplqqesgqtvectvaqyfkdrhklvlryphlpclqvgqeqkht
ylplevcnivagqrcikkltdnqtstmiratarsapdrqeeisklmrsadfntdpyvref
gimvkdemtdvtgrvlqppsilyggrnkaiatpvqgvwdmrnkqfhtgieikvwaiacfa
pqrqctevhlksfteqlrkisrdagmpiqgqpcfckyaqgadsvepmfrhlkntyaglql
vvvilpgktpvyaevkrvgdtvlgmatqcvqmknvqrttpqtlsnlclkinvklggvnni
llpqgrppvfqqpviflgadvthpppsiaavvgsmdahpnrycatvrvqqhrqeiiqdla
amvrelliqfykstrfkptriifyragvsegqfqqvlhhellaireaciklekdyqpgit
fivvqkrhhtrlfctdknervgksgnipagttvdtkithptefdfylcshagiqgtsrps
hyhvlwddnrfssdelqiltyqlchtyvrctrsvsipapayyahlvafraryhdhqalak
avqvhqdtlrtmyfa

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.