PDB entry 6mfq

View 6mfq on RCSB PDB site
Description: Crystal structure of a PMS2 variant
Class: hydrolase
Keywords: Mismatch Repair, Variant of Uncertain Significance, ATPase Domain, HYDROLASE, DNA Repair Enzyme
Deposited on 2018-09-11, released 2019-02-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-02-06, with a file datestamp of 2019-02-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: mismatch repair endonuclease pms2
    Species: Homo sapiens [TaxId:9606]
    Gene: PMS2, PMSL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54278 (Start-368)
      • variant (210)
    Domains in SCOPe 2.07: d6mfqa1, d6mfqa2
  • Chain 'B':
    Compound: mismatch repair endonuclease pms2
    Species: Homo sapiens [TaxId:9606]
    Gene: PMS2, PMSL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54278 (Start-368)
      • variant (210)
    Domains in SCOPe 2.07: d6mfqb1, d6mfqb2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6mfqA (A:)
gshmmeraessstepakaikpidrksvhqicsgqvvlslstavkelvensldagatnidl
klkdygvdlievsdngcgveeenfegltlkhhtskiqefadltqvetfgfrgealsslca
lsdvtistchasakvgtrlmfdhngkiiqktpyprprgttvsvqqlfstlpvrhkefqrn
ikkeyakmvqvlhayciisagirvsctnqleqgkrqpvvctggspsikenigsvfgqkql
qslipfvqlppsdsvceeyglscsdalhnlfyisgfisqcthgvgrsstdrqfffinrrp
cdpakvcrlvnevyhmynrhqypfvvlnisvdsecvdinvtpdkrqillqeeklllavlk
tsligmfds

    Sequence, based on observed residues (ATOM records): (download) 
    >6mfqA (A:)
lslstavkelvensldagatnidlklkdygvdlievsdngcgveeenfegltlealsslc
alsdvtistchasakvgtrlmfdhngkiiqktpyprprgttvsvqqlfstlpvrhkefqr
nikkeyakmvqvlhayciisagirvsctnqleqgkrqpvvctggspsikenigsvfgqkq
lqslipfvqlppsdsvceeyglscsdalhnlfyisgfisqcthgvgrsstdrqfffinrr
pcdpakvcrlvnevyhmynrhqypfvvlnisvdsecvdiqillqeeklllavlktsligm
fds

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6mfqB (B:)
gshmmeraessstepakaikpidrksvhqicsgqvvlslstavkelvensldagatnidl
klkdygvdlievsdngcgveeenfegltlkhhtskiqefadltqvetfgfrgealsslca
lsdvtistchasakvgtrlmfdhngkiiqktpyprprgttvsvqqlfstlpvrhkefqrn
ikkeyakmvqvlhayciisagirvsctnqleqgkrqpvvctggspsikenigsvfgqkql
qslipfvqlppsdsvceeyglscsdalhnlfyisgfisqcthgvgrsstdrqfffinrrp
cdpakvcrlvnevyhmynrhqypfvvlnisvdsecvdinvtpdkrqillqeeklllavlk
tsligmfds

    Sequence, based on observed residues (ATOM records): (download) 
    >6mfqB (B:)
lslstavkelvensldagatnidlklkdygvdlievsdngcgveeenfegltlealsslc
alsdvtistchasakvgtrlmfdhngkiiqktpyprprgttvsvqqlfstlpvrhkefqr
nikkeyakmvqvlhayciisagirvsctnqleqgkrqpvvctggspsikenigsvfgqkq
lqslipfvqlppsdsvceeyglscsdalhnlfyisgfisqcthgvgrsstdrqfffinrr
pcdpakvcrlvnevyhmynrhqypfvvlnisvdsecvdqillqeeklllavlktsligmf
ds