PDB entry 6mf0

View 6mf0 on RCSB PDB site
Description: crystal structure determination of human/porcine chimera coagulation factor viii
Deposited on 2018-09-07, released 2019-09-11
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Coagulation factor VIII chimera
    Species: Homo sapiens [TaxId:9606]
    Gene: F8, F8C
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Coagulation factor VIII chimera
    Species: Homo sapiens [TaxId:9606]
    Gene: F8, F8C
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CA, ZN, CU1, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6mf0A (A:)
mqlelstcvflcllplgfsairryylgavelswdyrqsellrelhvdtrfpatapgalpl
gpsvlykktvfveftdqlfsvarprppwmgllgptiqaevydtvvvtlknmashpvslha
vgvsfwkssegaeyedhtsqrekeddkvlpgksqtyvwqvlkengptasdppcltysyls
hvdlvkdlnsgligallvcregsltrertqnlhefvllfavfdegkswhsarndswtram
dpaparaqpamhtvngyvnrslpgligchkksvywhvigmgtspevhsifleghtflvrh
hrqasleispltfltaqtflmdlgqfllfchisshhhggmeahvrvescaeepqlrrkad
eeedyddnlydsdmdvvrldgddvspfiqirsvakkhpktwvhyiaaeeedwdyaplvla
pddrsyksqylnngpqrigrkykkvrfmaytdetfktreaiqhesgilgpllygevgdtl
liifknqasrpyniyphgitdvrplysrrlpkgvkhlkdfpilpgeifkykwtvtvedgp
tksdprcltryyssfvnmerdlasgligpllicykesvdqrgnqimsdkrnvilfsvfde
nrswylteniqrflpnpagvqledpefqasnimhsingyvfdslqlsvclhevaywyils
igaqtdflsvffsgytfkhkmvyedtltlfpfsgetvfmsmenpglwilgchnsdfrnrg
mtallkvsscdkntgdyyedsyedisayllsknnaieprsfaqnsrppsasapkppvlrr
hqrdislptfqpeedkmdyddifstetkgedfdiygedenqdprsfqkrtrhyfiaaveq
lwdygmsespralrnraqngevprfkkvvfrefadgsftqpsyrgelnkhlgllgpyira
evednimvtfknqasrpysfysslisypddqeqgaeprhnfvqpnetrtyfwkvqhhmap
tedefdckawayfsdvdlekdvhsgligpllicrantlnaahgrqvtvqefalfftifde
tkswyftenverncrapchlqmedptlkenyrfhaingyvmdtlpglvmaqnqrirwyll
smgsnenihsihfsghvfsvrkkeeykmavynlypgvfetvemlpskvgiwriecligeh
lqagmsttflvyskkcqtplgmasghirdfqitasgqygqwapklarlhysgsinawstk
epfswikvdllapmiihgiktqgarqkfsslyisqfiimysldgkkwqtyrgnstgtlmv
ffgnvdssgikhnifnppiiaryirlhpthysirstlrmelmgcdlnscsmplgmeskai
sdaqitassyftnmfatwspskarlhlqgrsnawrpqvnnpkewlqvdfqktmkvtgvtt
qgvkslltsmyvkeflisssqdghqwtlffqngkvkvfqgnqdsftpvvnsldpplltry
lrihpqswvhqialrmevlgceaqdly

    Sequence, based on observed residues (ATOM records):
    >6mf0A (A:)
airryylgavelswdyrqsellrelhvdtrfpatapgalplgpsvlykktvfveftdqlf
svarprppwmgllgptiqaevydtvvvtlknmashpvslhavgvsfwkssegaeyedhts
qrekeddkvlpgksqtyvwqvlkengptasdppcltysylshvdlvkdlnsgligallvc
regsltrertqnlhefvllfavfdegkswhsaaqpamhtvngyvnrslpgligchkksvy
whvigmgtspevhsifleghtflvrhhrqasleispltfltaqtflmdlgqfllfchiss
hhhggmeahvrvescaekhpktwvhyiaaeeedwdyaplvlapddrsyksqylnngpqri
grkykkvrfmaytdetfktreaiqhesgilgpllygevgdtlliifknqasrpyniyphg
itdvrplysrrlpkgvkhlkdfpilpgeifkykwtvtvedgptksdprcltryyssfvnm
erdlasgligpllicykesdkrnvilfsvfdenrswylteniqrflpnpagvqledpefq
asnimhsingyvfdslqlsvclhevaywyilsigaqtdflsvffsgytfkhkmvyedtlt
lfpfsgetvfmsmenpglwilgchnsdfrnrgmtallkvssckrtrhyfiaaveqlwdyg
msesvprfkkvvfrefadgsftqpsyrgelnkhlgllgpyiraevednimvtfknqasrp
ysfysslisypddqeqgaeprhnfvqpnetrtyfwkvqhhmaptedefdckawayfsdvd
lekdvhsgligpllicrantlnaahgrqvtvqefalfftifdetkswyftenvernctlk
enyrfhaingyvmdtlpglvmaqnqrirwyllsmgsnenihsihfsghvfsvrkkeeykm
avynlypgvfetvemlpskvgiwriecligehlqagmsttflvyskkcqtplgmasghir
dfqitasgqygqwapklarlhysgsinawstkepfswikvdllapmiihgiktqgarqkf
sslyisqfiimysldgkkwqtyrgnstgtlmvffgnvdssgikhnifnppiiaryirlhp
thysirstlrmelmgcdlnscsmplgmeskaisdaqitassyftnmfatwspskarlhlq
grsnawrpqvnnpkewlqvdfqktmkvtgvttqgvkslltsmyvkeflisssqdghqwtl
ffqngkvkvfqgnqdsftpvvnsldpplltrylrihpqswvhqialrmevlgceaq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6mf0B (B:)
mqlelstcvflcllplgfsairryylgavelswdyrqsellrelhvdtrfpatapgalpl
gpsvlykktvfveftdqlfsvarprppwmgllgptiqaevydtvvvtlknmashpvslha
vgvsfwkssegaeyedhtsqrekeddkvlpgksqtyvwqvlkengptasdppcltysyls
hvdlvkdlnsgligallvcregsltrertqnlhefvllfavfdegkswhsarndswtram
dpaparaqpamhtvngyvnrslpgligchkksvywhvigmgtspevhsifleghtflvrh
hrqasleispltfltaqtflmdlgqfllfchisshhhggmeahvrvescaeepqlrrkad
eeedyddnlydsdmdvvrldgddvspfiqirsvakkhpktwvhyiaaeeedwdyaplvla
pddrsyksqylnngpqrigrkykkvrfmaytdetfktreaiqhesgilgpllygevgdtl
liifknqasrpyniyphgitdvrplysrrlpkgvkhlkdfpilpgeifkykwtvtvedgp
tksdprcltryyssfvnmerdlasgligpllicykesvdqrgnqimsdkrnvilfsvfde
nrswylteniqrflpnpagvqledpefqasnimhsingyvfdslqlsvclhevaywyils
igaqtdflsvffsgytfkhkmvyedtltlfpfsgetvfmsmenpglwilgchnsdfrnrg
mtallkvsscdkntgdyyedsyedisayllsknnaieprsfaqnsrppsasapkppvlrr
hqrdislptfqpeedkmdyddifstetkgedfdiygedenqdprsfqkrtrhyfiaaveq
lwdygmsespralrnraqngevprfkkvvfrefadgsftqpsyrgelnkhlgllgpyira
evednimvtfknqasrpysfysslisypddqeqgaeprhnfvqpnetrtyfwkvqhhmap
tedefdckawayfsdvdlekdvhsgligpllicrantlnaahgrqvtvqefalfftifde
tkswyftenverncrapchlqmedptlkenyrfhaingyvmdtlpglvmaqnqrirwyll
smgsnenihsihfsghvfsvrkkeeykmavynlypgvfetvemlpskvgiwriecligeh
lqagmsttflvyskkcqtplgmasghirdfqitasgqygqwapklarlhysgsinawstk
epfswikvdllapmiihgiktqgarqkfsslyisqfiimysldgkkwqtyrgnstgtlmv
ffgnvdssgikhnifnppiiaryirlhpthysirstlrmelmgcdlnscsmplgmeskai
sdaqitassyftnmfatwspskarlhlqgrsnawrpqvnnpkewlqvdfqktmkvtgvtt
qgvkslltsmyvkeflisssqdghqwtlffqngkvkvfqgnqdsftpvvnsldpplltry
lrihpqswvhqialrmevlgceaqdly

    Sequence, based on observed residues (ATOM records):
    >6mf0B (B:)
airryylgavelswdyrqsellrelhvdtrgpsvlykktvfveftdqlfsvarprppwmg
llgptiqaevydtvvvtlknmashpvslhavgvsfwkssegaeyedhtsqrekeddkvlp
gksqtyvwqvlkengptasdppcltysylshvdlvkdlnsgligallvcregsltrertq
nlhefvllfavfdegkswhsaaqpamhtvngyvnrslpgligchkksvywhvigmgtspe
vhsifleghtflvrhhrqasleispltfltaqtflmdlgqfllfchisshhhggmeahvr
vescaekhpktwvhyiaaeeedwdyaplvlapddrsyksqylnngpqrigrkykkvrfma
ytdetfktreaiqhesgilgpllygevgdtlliifknqasrpyniyphgitdvrplysrr
lpkgvkhlkdfpilpgeifkykwtvtvedgptksdprcltryyssfvnmerdlasgligp
llicyksdkrnvilfsvfdenrswylteniqrflpnpagvqledpefqasnimhsingyv
fdslqlsvclhevaywyilsigaqtdflsvffsgytfkhkmvyedtltlfpfsgetvfms
menpglwilgchnsdfrnrgmtallkvssckrtrhyfiaaveqlwdygmsespgevprfk
kvvfrefadgsftqpsyrgelnkhlgllgpyiraevednimvtfknqasrpysfysslis
ypddqeqgaeprhnfvqpnetrtyfwkvqhhmaptedefdckawayfsdvdlekdvhsgl
igpllicrantlnaahgrqvtvqefalfftifdetkswyftenvernctlkenyrfhain
gyvmdtlpglvmaqnqrirwyllsmgsnenihsihfsghvfsvrkkeeykmavynlypgv
fetvemlpskvgiwriecligehlqagmsttflvyskkcqtplgmasghirdfqitasgq
ygqwapklarlhysgsinawstkepfswikvdllapmiihgiktqgarqkfsslyisqfi
imysldgkkwqtyrgnstgtlmvffgnvdssgikhnifnppiiaryirlhpthysirstl
rmelmgcdlnscsmplgmeskaisdaqitassyftnmfatwspskarlhlqgrsnawrpq
vnnpkewlqvdfqktmkvtgvttqgvkslltsmyvkeflisssqdghqwtlffqngkvkv
fqgnqdsftpvvnsldpplltrylrihpqswvhqialrmevlgceaq