SCOPe 2.08: Structural Classification of Proteins

PDB entry 6mej

View 6mej on RCSB PDB site
Description: Crystal structure of Hepatitis C virus envelope glycoprotein E2 ectodomain in complex with human antibodies HEPC3 and HEPC46
Class: immune system
Keywords: HCV glycoprotein, broadly neutralizing antibodies, IMMUNE SYSTEM
Deposited on 2018-09-06, released 2018-11-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: antibody HEPC46 Heavy Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6MEJ (0-End)
Domains in SCOPe 2.08: d6meja_
Chain 'B':
Compound: antibody HEPC46 Light Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6MEJ
Domains in SCOPe 2.08: d6mejb1, d6mejb2
Chain 'C':
Compound: e2 glycoprotein
Species: Hepacivirus C [TaxId:11103]
Database cross-references and differences (RAF-indexed):
- Uniprot C1KH25 (Start-261)
Chain 'H':
Compound: antibody HEPC3 Heavy Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6MEJ (0-End)
Domains in SCOPe 2.08: d6mejh_
Chain 'L':
Compound: antibody HEPC3 Light Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6MEJ (0-End)
Domains in SCOPe 2.08: d6mejl1, d6mejl2
Heterogens: NAG

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>6mejA (A:)
qvqlvqsgaevkkpgasvkvsckasgyiftshgiswvrqapgqglewmgwisvyngytny
aqnlqgrvtmttdtststaymelrslrsddtavyfcarasqirgvdywgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkthhhhhh

Sequence, based on observed residues (ATOM records): (download)

>6mejA (A:)
qvqlvqsgaevkkpgasvkvsckasgyiftshgiswvrqapgqglewmgwisvyngytny
aqnlqgrvtmttdtststaymelrslrsddtavyfcarasqirgvdywgqgtlvtvssas
tkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls
svvtvpssslgtqtyicnvnhkpsntkvdkrvepk

Chain 'B':
Sequence, based on SEQRES records: (download)

>6mejB (B:)
qsvltqppsasgtpgqrvtiscsgsssnigsnyvywyqqfpgtapklliygnnqrpsgvp
drfsgsksgtsaslaisglrsedeadyycaawddslsgpwvfgggtqvtvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvaptecs

Sequence, based on observed residues (ATOM records): (download)

>6mejB (B:)
svltqppsasgtpgqrvtiscsgsssnigsnyvywyqqfpgtapklliygnnqrpsgvpd
rfsgsksgtsaslaisglrsedeadyycaawddslsgpwvfgggtqvtvlgqpkaapsvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvap

Chain 'C':
No sequence available.

Chain 'H':
Sequence, based on SEQRES records: (download)

>6mejH (H:)
qvqlvqsgaevkkpgssvkvsckasggtlnsyeitwvrqapgqglewmggitpifettya
qkfqgrvtitadeststtymelsslrpedtavyycardgvrycgggrcynwfdpwgqgtl
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdktagwshpqfe
k

Sequence, based on observed residues (ATOM records): (download)

>6mejH (H:)
qvqlvqsgaevkkpgssvkvsckasggtlnsyeitwvrqapgqglewmggitpifettya
qkfqgrvtitadeststtymelsslrpedtavyycardgvrycgggrcynwfdpwgqgtl
vtvssastkgpsvfplapsstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks

Chain 'L':
Sequence, based on SEQRES records: (download)

>6mejL (L:)
diqmtqspsslsasvgdrvtitcragqninnylnwyqqkpgkapkvliyaasnlqsgvps
rfsgsgsgtdftltisslqpedfatyycqqshstvrtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

Sequence, based on observed residues (ATOM records): (download)

>6mejL (L:)
diqmtqspsslsasvgdrvtitcragqninnylnwyqqkpgkapkvliyaasnlqsgvps
rfsgsgsgtdftltisslqpedfatyycqqshstvrtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge