PDB entry 6mco

View 6mco on RCSB PDB site
Description: crystal structure of the b41 sosip.664 env trimer with pgt124 and 35o22 fabs, in p23 space group
Deposited on 2018-08-31, released 2019-02-27
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-09.
Experiment type: XRAY
Resolution: 3.53 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: Transmembrane protein gp41
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot B3UF08 (0-152)
      • conflict (93)
  • Chain 'D':
    Compound: 35O22 Fab Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MCO (0-End)
  • Chain 'E':
    Compound: 35O22 Fab Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MCO
  • Chain 'G':
    Compound: Surface protein gp120
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot B3UES2 (0-481)
      • conflict (475)
  • Chain 'H':
    Compound: PGT124 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MCO (0-End)
  • Chain 'L':
    Compound: PGT124 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6MCO (0-End)
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6mcoB (B:)
avglgafilgflgaagstmgaasmaltvqarlllsgivqqqnnllraieaqqhmlqltvw
gikqlqarvlaverylrdqqllgiwgcsgkiicctnvpwndswsnktineiwdnmtwmqw
ekeidnytqhiytllevsqiqqekneqelleld

    Sequence, based on observed residues (ATOM records):
    >6mcoB (B:)
avglgafilgflgaagstmgaasmaltvqarlllsqltvwgikqlqarvlaverylrdqq
llgiwgcsgkiicctnvpwndswsnktineiwdnmtwmqwekeidnytqhiytllevsqi
qqekneqelleld

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6mcoD (D:)
egqlvqsgaelkkpgasvkiscktsgyrfnfyhinwirqtagrgpewmgwispysgdknl
apafqdrvimttdtevpvtsftstgaaymeirnlkfddtgtyfcakgllrdgsstwlpyl
wgqgtlltvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsg
vhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkglev
lfq

    Sequence, based on observed residues (ATOM records):
    >6mcoD (D:)
egqlvqsgaelkkpgasvkiscktsgyrfnfyhinwirqtagrgpewmgwispysgdknl
apafqdrvimttdtevpvtsftstgaaymeirnlkfddtgtyfcakgllrdgsstwlpyl
wgqgtlltvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsg
vhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkglev

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6mcoE (E:)
qsvltqsasvsgslgqsvtisctgpnsvccshksiswyqwppgraptliiyednerapgi
sprfsgyksywsayltisdlrpedettyyccsythnsgcvfgtgtkvsvlgqskanpsvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6mcoE (E:)
svltqsasvsgslgqsvtisctgpnsvccshksiswyqwppgraptliiyednerapgis
prfsgyksywsayltisdlrpedettyyccsythnsgcvfgtgtkvsvlgqskanpsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6mcoG (G:)
akkwvtvyygvpvwkeatttlfcasdakaydtevhnvwathacvptdpnpqeivlgnvte
nfnmwknnmveqmhediislwdqslkpcvkltplcvtlncnnvntnntnnstnatisdwe
kmetgemkncsfnvttsirdkikkeyalfykldvvplenknninntnitnyrlincntsv
itqacpkvsfepipihycapagfailkcnsktfngsgpctnvstvqcthgirpvvstqll
lngslaeeeivirsenitdnaktiivqlneaveinctrpnnntrksihigpgrafyatgd
iignirqahcniskarwnetlgqivakleeqfpnktiifnhssggdpeivthsfncggef
fycnttplfnstwnntrtddyptggeqnitlqcrikqiinmwqgvgkamyappirgqirc
ssnitgllltrdggrdqngtetfrpgggnmrdnwrselykykvvkieplgiaptackrrv
vq

    Sequence, based on observed residues (ATOM records):
    >6mcoG (G:)
akkwvtvyygvpvwkeatttlfcasdakaydtevhnvwathacvptdpnpqeivlgnvte
nfnmwknnmveqmhediislwdqslkpcvkltplcvtlncnnvntnntntgemkncsfnv
ttsirdkikkeyalfykldvvplitnyrlincntsvitqacpkvsfepipihycapagfa
ilkcnsktfngsgpctnvstvqcthgirpvvstqlllngslaeeeivirsenitdnakti
ivqlneaveinctrpnnntrksihigpgrafyatgdiignirqahcniskarwnetlgqi
vakleeqfpnktiifnhssggdpeivthsfncggeffycnttplfnstwnntrtddypge
qnitlqcrikqiinmwqgvgkamyappirgqircssnitgllltrdggrdqngtetfrpg
ggnmrdnwrselykykvvkieplgiaptackrrvvq

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6mcoH (H:)
qvqlqesgpglvrpsetlsvtcivsggsisnyywtwirqspgkglewigyisdretttyn
pslnsravisrdtsknqlslqlrsvttadtaiyfcatarrgqriygvvsfgeffyyyymd
vwgkgtavtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscd

    Sequence, based on observed residues (ATOM records):
    >6mcoH (H:)
qvqlqesgpglvrpsetlsvtcivsggsisnyywtwirqspgkglewigyisdretttyn
pslnsravisrdtsknqlslqlrsvttadtaiyfcatarrgqriygvvsfgeffyyyymd
vwgkgtavtvssastkgpsvfplapssstsggtaalgclvkdyfpepvtvswnsgaltsg
vhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6mcoL (L:)
syvsplsvalgetariscgrqalgsravqwyqhkpgqapilliynnqdrpsgiperfsgt
pdinfgttatltisgvevgdeadyychmwdsrsgfswsfggatrltvlsqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshksyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6mcoL (L:)
syvsplsvalgetariscgrqalgsravqwyqhkpgqapilliynnqdrpsgiperfsgt
pdinfgttatltisgvevgdeadyychmwdsrsgfswsfggatrltvlsqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshksyscqvthegstvektvapt