PDB entry 6mb0

View 6mb0 on RCSB PDB site
Description: Crystal structure of N-myristoyl transferase (NMT) G386E mutant from Plasmodium vivax in complex with inhibitor IMP-1002
Class: transferase
Keywords: SSGCID, glycylpeptide N-tetradecanoyltransferase, N-myristoyltransferase, NMT, Salvador I, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, TRANSFERASE
Deposited on 2018-08-29, released 2019-06-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-31, with a file datestamp of 2019-07-26.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycylpeptide N-tetradecanoyltransferase
    Species: Plasmodium vivax [TaxId:5855]
    Gene: PVC01_130042700, PVP01_1336100
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A1G4HIY1 (21-404)
      • expression tag (20)
      • engineered mutation (380)
    Domains in SCOPe 2.08: d6mb0a1, d6mb0a2
  • Chain 'B':
    Compound: Glycylpeptide N-tetradecanoyltransferase
    Species: Plasmodium vivax [TaxId:5855]
    Gene: PVC01_130042700, PVP01_1336100
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A1G4HIY1 (21-404)
      • expression tag (20)
      • engineered mutation (380)
    Domains in SCOPe 2.08: d6mb0b1, d6mb0b2
  • Chain 'C':
    Compound: Glycylpeptide N-tetradecanoyltransferase
    Species: Plasmodium vivax [TaxId:5855]
    Gene: PVC01_130042700, PVP01_1336100
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A1G4HIY1 (21-404)
      • expression tag (20)
      • engineered mutation (380)
    Domains in SCOPe 2.08: d6mb0c1, d6mb0c2
  • Heterogens: JCY, YNC, SO4, CL, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6mb0A (A:)
mgsshhhhhhsaalevlfqgpdykfwytqpvpkindefnesvnepfisdnkvedvrkdey
klppgyswyvcdvkdekdrseiytlltdnyvedddnifrfnysaefllwaltspnylktw
higvkydasnkligfisaiptdicihkrtikmaevnflcvhktlrskrlapvlikeitrr
inleniwqaiytagvylpkpvsdaryyhrsinvkklieigfsslnsrltmsraiklyrve
dtlniknmrlmkkkdvegvhkllgsyleqfnlyavftkeeiahwflpienviytyvneen
gkikdmisfyslpsqilgndkystlnaaysfynvtttatfkqlmqdaillakrnnfdvfn
alevmqnksvfedlkfgegdeslkyylynwkcasfapahvgivll

    Sequence, based on observed residues (ATOM records): (download) 
    >6mb0A (A:)
pdykfwytqpvpkindefnesvnepfisdnkvedvrkdeyklppgyswyvcdvkdekdrs
eiytlltdnyvedddnifrfnysaefllwaltspnylktwhigvkydasnkligfisaip
tdicihkrtikmaevnflcvhktlrskrlapvlikeitrrinleniwqaiytagvylpkp
vsdaryyhrsinvkklieigfsslnsrltmsraiklyrvedtlniknmrlmkkkdvegvh
kllgsyleqfnlyavftkeeiahwflpienviytyvneengkikdmisfyslpsqilgnd
kystlnaaysfynvtttatfkqlmqdaillakrnnfdvfnalevmqnksvfedlkfgegd
eslkyylynwkcasfapahvgivll

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6mb0B (B:)
mgsshhhhhhsaalevlfqgpdykfwytqpvpkindefnesvnepfisdnkvedvrkdey
klppgyswyvcdvkdekdrseiytlltdnyvedddnifrfnysaefllwaltspnylktw
higvkydasnkligfisaiptdicihkrtikmaevnflcvhktlrskrlapvlikeitrr
inleniwqaiytagvylpkpvsdaryyhrsinvkklieigfsslnsrltmsraiklyrve
dtlniknmrlmkkkdvegvhkllgsyleqfnlyavftkeeiahwflpienviytyvneen
gkikdmisfyslpsqilgndkystlnaaysfynvtttatfkqlmqdaillakrnnfdvfn
alevmqnksvfedlkfgegdeslkyylynwkcasfapahvgivll

    Sequence, based on observed residues (ATOM records): (download) 
    >6mb0B (B:)
pdykfwytqpvpkindefnesvnepfisdnkvedvrkdeyklppgyswyvcdvkdekdrs
eiytlltdnyvedddnifrfnysaefllwaltspnylktwhigvkydasnkligfisaip
tdicihkrtikmaevnflcvhktlrskrlapvlikeitrrinleniwqaiytagvylpkp
vsdaryyhrsinvkklieigfsslnsrltmsraiklyrvedtlniknmrlmkkkdvegvh
kllgsyleqfnlyavftkeeiahwflpienviytyvneengkikdmisfyslpsqilgnd
kystlnaaysfynvtttatfkqlmqdaillakrnnfdvfnalevmqnksvfedlkfgegd
eslkyylynwkcasfapahvgivll

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6mb0C (C:)
mgsshhhhhhsaalevlfqgpdykfwytqpvpkindefnesvnepfisdnkvedvrkdey
klppgyswyvcdvkdekdrseiytlltdnyvedddnifrfnysaefllwaltspnylktw
higvkydasnkligfisaiptdicihkrtikmaevnflcvhktlrskrlapvlikeitrr
inleniwqaiytagvylpkpvsdaryyhrsinvkklieigfsslnsrltmsraiklyrve
dtlniknmrlmkkkdvegvhkllgsyleqfnlyavftkeeiahwflpienviytyvneen
gkikdmisfyslpsqilgndkystlnaaysfynvtttatfkqlmqdaillakrnnfdvfn
alevmqnksvfedlkfgegdeslkyylynwkcasfapahvgivll

    Sequence, based on observed residues (ATOM records): (download) 
    >6mb0C (C:)
pdykfwytqpvpkindefnesvnepfisdnkvedvrkdeyklppgyswyvcdvkdekdrs
eiytlltdnyvedddnifrfnysaefllwaltspnylktwhigvkydasnkligfisaip
tdicihkrtikmaevnflcvhktlrskrlapvlikeitrrinleniwqaiytagvylpkp
vsdaryyhrsinvkklieigfaiklyrvedtlniknmrlmkkkdvegvhkllgsyleqfn
lyavftkeeiahwflpienviytyvneengkikdmisfyslpsqilgndkystlnaaysf
ynvtttatfkqlmqdaillakrnnfdvfnalevmqnksvfedlkfgegdeslkyylynwk
casfapahvgivll