PDB entry 6mav

View 6mav on RCSB PDB site
Description: Complex of tissue inhibitor of metalloproteinase-1 (TIMP-1) mutant L34G with matrix metalloproteinase-3 catalytic domain (MMP-3cd)
Class: HYDROLASE/HYDROLASE inhibitor
Keywords: Protease inhibitor, Matrix metalloproteinase-3 (MMP-3), Tissue inhibitor of metalloproteinase-1 (TIMP-1), HYDROLASE-HYDROLASE inhibitor complex
Deposited on 2018-08-28, released 2019-05-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-27, with a file datestamp of 2019-11-22.
Experiment type: XRAY
Resolution: 2.37 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: stromelysin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP3, STMY1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mava_
  • Chain 'B':
    Compound: Metalloproteinase inhibitor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TIMP1, CLGI, TIMP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01033 (0-End)
      • engineered mutation (33)
    Domains in SCOPe 2.08: d6mavb_
  • Heterogens: CA, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6mavA (A:)
frtfpgipkwrkthltyrivnytpdlpkdavdsavekalkvweevtpltfsrlyegeadi
misfavrehgdfypfdgpgnvlahayapgpgingdahfdddeqwtkdttgtnlflvaahe
ighslglfhsantealmyplyhsltdltrfrlsqddingiqslygppp

    Sequence, based on observed residues (ATOM records): (download) 
    >6mavA (A:)
pgipkwrkthltyrivnytpdlpkdavdsavekalkvweevtpltfsrlyegeadimisf
avrehgdfypfdgpgnvlahayapgpgingdahfdddeqwtkdttgtnlflvaaheighs
lglfhsantealmyplyhsltdltrfrlsqddingiqslyg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6mavB (B:)
ctcvpphpqtafcnsdlvirakfvgtpevnqttgyqryeikmtkmykgfqalgdaadirf
vytpamesvcgyfhrshnrseefliagklqdgllhittcsfvapwnslslaqrrgftkty
tvgceectvfpclsipcklqsgthclwtdqllqgsekgfqsrhlaclprepglctwqslr
sqia

    Sequence, based on observed residues (ATOM records): (download) 
    >6mavB (B:)
ctcvpphpqtafcnsdlvirakfvgtpevnqttgyqryeikmtkmykgfqadirfvytpa
mesvcgyfhrshnrseefliagklqdgllhittcsfvapwnslslaqrrgftktytvgce
ectvfpclsipcklqsgthclwtdqllqgsekgfqsrhlaclprepglctwqsl