PDB entry 6ma7

View 6ma7 on RCSB PDB site
Description: Human CYP3A4 bound to an inhibitor fluconazole
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex, CYP3A4
Deposited on 2018-08-26, released 2019-01-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cytochrome p450 3a4
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP3A4, CYP3A3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08684
      • conflict (248)
    Domains in SCOPe 2.08: d6ma7a_
  • Heterogens: HEM, TPF, DMS, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ma7A (A:)
maylygthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqp
vlaitdpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsg
klkemvpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpq
dpfventkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesr
ledtqkhrtdflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimye
lathpdvqqklqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkd
veingmfipkgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgpr
ncigmrfalmnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrdgtv
sgahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6ma7A (A:)
gthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlait
dpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkem
vpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfve
ntkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrledtd
flqlmidsqnsshkalsdlelvaqsiififagyettssvlsfimyelathpdvqqklqee
idavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvv
mipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprncigmrfalmnmkl
alirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrd